JP2769587B2 - Powder nutrition composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a powdered nutritional composition, and more particularly to a powdered nutritional composition prepared using a new fatty amino acid powder.

[0002]

2. Description of the Related Art Conventionally, enteral nutrition has been used to administer artificial nutrition by mouth or through a tube to patients before and after surgery who cannot take a normal diet or the like to restore physical strength and promote healing. In the enteral nutrition method, the method of administering through a tube, for example, the nutrition is directly administered to the gastrointestinal tract via a tube or a gastrostomy or a jejunostomy inserted nasally into a patient. This is called tube-tube therapy,
It is applied to post-operative patients and the like before oral intake, and provides desired effects. Enteral nutrition, in which nutrients are administered in the form of digested chemical components (component nutrition), has been applied to early postoperative patients, which allows high-calorie administration and further enhances the patient's ability. There is an advantage that the rate of nutrient absorption can be increased. In addition, this method has the advantages of being residue-free, having good flowability, and being relatively easy to prepare. One of them is considered extremely important.

[0003] From the viewpoint of storage stability, the component nutrients used in the enteral nutrition method are preferably in the form of a powder for dissolution at the time of use, rather than in the form of a liquid, and most of the currently known component nutrients. It has almost any powder form.

[0004] The above-mentioned preparation in powder form and its production method include (1) a method of powder-mixing each component such as amino acids, sugars, powdered fats, vitamins and minerals,
(2) A method of mixing and emulsifying all the components, followed by spray drying (JP-A-51-26238, JP-A-52-83967).
And the like, but each has the following disadvantages.

[0005] That is, when the powder preparation of (1) is added to water, amino acids (particularly valine, leucine, isoleucine, etc.) are difficult to dissolve, fats float in water, and are hard to disperse. There are various problems such as the formation of a lump and difficulty in dispersing, and the risk of clogging the administration tube and the risk of preventing absorption. As a countermeasure, a method in which each component is granulated in advance and then mixed is performed, but this method improves the dispersibility, but does not improve the solubility of the amino acid.

Further, powder formulations of (2) is susceptible to changes, such as main Irado reaction, because they involve many emulsifiers, emulsifiers high HLB is required, which is not easily cause diarrhea due remains There are problems such as the formation (small lumps) and difficult dispersion.

On the other hand, in order to improve the dispersibility of powdered nutrients in water and the like, various studies have been made on powdering fats (JP-A-50-70513, JP-A-50-70513).
Japanese Patent Application Laid-Open No. 70505/1995 and Japanese Patent Application Laid-Open No. 50-55831), none of which completely solves the above problems.

The inventors of the present invention have conducted intensive studies based on the above-mentioned situation. As a result, the powder obtained by emulsifying fat with amino acids and then spray-drying the powder may produce an insoluble solid when added to water. And found that a stable emulsion could be obtained, and that the HLB and amount of the emulsifier used could be kept low with this powder. Furthermore, when powdering fat and amino acids, carbohydrates do not coexist,
A stable powder that does not cause a change such as the Maillard reaction can be obtained. In addition, by mixing the powder with a granulated saccharide, the obtained nutritional composition has a very good dispersibility in water. And succeeded in solving all of the above-mentioned problems, thereby completing the present invention.

[0009]

That is, the present invention relates to a spray-dried powder of an oil-in-water emulsion obtained by emulsifying a fat in an aqueous amino acid solution in the presence of an emulsifier, wherein the emulsifier is a sucrose fatty acid ester or a polysulfate. At least one selected from glycerin fatty acid esters or a mixture thereof with lecithin, the HLB of which is in the range of 9 to 16, and the amount of use is 2.5 to 10% by weight of the total weight of fat and amino acid; And the weight ratio of fat to amino acid is 1: 1.5
To 4.0 amino acid powder (hereinafter referred to as "the present fatty amino acid powder") and granulated saccharide in a ratio of 1.5 to 5.0 g to 1 g of the powder. The present invention relates to a powdered nutritional composition characterized by containing.

Examples of the fat used in the present invention include long-chain fatty acid triglycerides (LCT) such as soybean oil, sesame oil, cottonseed oil, corn oil and rice oil, which usually have 8 to 10 carbon atoms. Medium chain fatty acid triglyceride (MCT) may be mixed.

The amino acid may be a single product or a mixture, but is preferably selected from the following composition ranges. Each amino acid may be in a free form, or a part of a salt, ester or peptide.

[0012]

[Table 1]

[0013] The sugars include glucose, sucrose, lactose,
Dextrin and the like can be exemplified. Among them, dextrin is preferable, and by using granulated one, the dispersibility can be further improved. In addition, a conventionally well-known method is employ | adopted as a granulation method. It is more preferable to use dextrin which is made free of high molecular weight substances by means such as control of enzymatic decomposition.

The mixing ratio of the above components is preferably fat: amino acid: saccharide = 1: 1.5-4.0: 5-25 (weight ratio).

The emulsifier is selected from those having an HLB in the range of 9 to 16, and among them, sucrose fatty acid esters and polyglycerin fatty acid esters can be suitably used. Can also be used. Further, lecithin such as soybean lecithin and egg yolk lecithin may be mixed. The amount to be used is preferably 2.5 to 10% (W / W) of the total weight of fat and amino acid. There is a disadvantage to doing.

The fatty amino acid powder of the present invention may further contain commonly used additives such as vitamins and minerals. Vitamin A,
Examples of vitamin B ₁ , vitamin B ₂ , vitamin B ₆ , vitamin B ₁₂ , vitamin C, vitamin D, vitamin E, vitamin K, nicotinamide, folic acid, pantothenic acid, bition, choline, etc. Necessary types and amounts are determined and can be appropriately blended within the range. Examples of the mineral include sodium chloride, potassium chloride, calcium glycerophosphate, magnesium sulfate, manganese sulfate, zinc sulfate, iron sulfate, and copper sulfate. Other additives that can be added and compounded as needed further include flavors, sweeteners, coloring agents, stabilizers, preservatives, preservatives,
A pH adjuster and the like can be exemplified.

The following method can be employed as a method for producing the fatty amino acid powder of the present invention. That is, first, an amino acid is added to an appropriate amount of water and heated to completely dissolve (the concentration is 10 to 20% W
/ V is preferred). It should be noted that the aqueous solution may contain some or all of the components other than sugars such as vitamins and minerals. Next, a fat and an emulsifier are added and mixed and emulsified by a conventional method to obtain an oil-in-water emulsion. The liquid temperature at this time is preferably from 60 to 80 ° C. Next, the fatty acid amino acid powder of the present invention can be obtained by spray-drying this emulsion using an ordinary spray dryer.

The powdered nutrient composition of the present invention obtained by using the above-mentioned fatty acid amino acid powder of the present invention is obtained, for example, by mixing granulated saccharide with the above-obtained fatty acid amino acid powder,
Furthermore, if necessary, vitamins and minerals may be added, mixed uniformly, and sealed, for example, in an aluminum laminated film container, preferably with a nitrogen purge.

The thus obtained powdered nutritional composition of the present invention, like a normal powdered nutritional composition, is placed in water at the time of administration and uniformly stirred and mixed to give a total concentration of about 0.5 to 0.5.
2.5 kcal / ml (about 125-600 mg / ml)
(PH about 6.0-6.7) and administered. The method of administration is similar to that of a general enteral nutrition composition, and is usually administered by gavage to the stomach, duodenum or small intestine, or orally, in an amount equivalent to about 800 to 2500 kcal per person per day. The dosage depends on the patient's condition,
It can be appropriately increased or decreased according to the nutritional state, age, weight, and the like.

[0020]

The fatty amino acid powder of the present invention can be sufficiently emulsified by adding a small amount of an emulsifier without using a high HLB emulsifier without generating an insoluble amino acid solid when added to water. Become. In addition, it is stable without causing a change such as the Maillard reaction.

Further, the powdered nutritional composition of the present invention, which is obtained by mixing the above fatty acid amino acid powder with the granulated saccharide, is rapidly dispersed in water, so that the dissolving operation is simple and the dissolving is performed by a mixer.
There is no need for equipment such as In addition, it does not generate mushrooms (small lumps) and maintains the emulsion stability for a long time. Thus, there is no risk of clogging the tube during tube administration and absorption of the patient is not impeded. In addition, it is less likely to cause diarrhea in patients and is ideal as a component nutrient.

[0022]

The present invention will be described in more detail with reference to the following examples.

[0023]

Example 1 An amino acid having the following composition was added to 5000 ml of purified water, and dissolved by heating to about 70 to 80 ° C.

[0024]

[Table 2]

Next, 10 g of soybean lecithin (Epiclon 100; manufactured by Nippon Siebel-Hegner) was dissolved in 222 g of soybean oil (manufactured by NOF Corporation) by heating, and sucrose fatty acid ester (DK-F160; manufactured by Daiichi Kogyo Seiyaku Co., Ltd.) HLB = 15)
30 g was heated and dissolved in 1000 ml of purified water, and the three liquids were mixed and emulsified using an emulsifier (MANTON-GAUIN; manufactured by Doei Shoji). The obtained emulsion is spray-dried (A
Drying was carried out using DV-ANHYDRO) to obtain 910 g (100% = 1016 g) of the fatty acid amino acid powder of the present invention.

[0026]

Embodiment 2

[0027]

[Table 3]

The amino acid having the above composition, 222 g of soybean oil (manufactured by NOF Corporation) as a fat and soybean lecithin (Epiclon 100; manufactured by Nippon Siebel-Hegner) as an emulsifier
10 g and sucrose fatty acid ester (DK-F160;
910 g of fatty acid amino acid powder of the present invention in the same manner as in Example 1 using 30 g of Daiichi Kogyo Seiyaku Co., Ltd., HLB = 15)
(100% = 1014 g) was obtained.

[0029]

Embodiment 3

[0030]

[Table 4]

Amino acid having the above composition, 222 g of soybean oil (manufactured by NOF Corporation) as a fat, and soybean lecithin (Epiclon 100; manufactured by Nippon Siebel-Hegner) as an emulsifier
10 g and sucrose fatty acid ester (DK-F160;
Using 30 g of Daiichi Kogyo Seiyaku Co., Ltd., HLB = 15), 920 g of the fatty acid amino acid powder of the present invention in the same manner as in Example 1.
(100% = 1030 g) was obtained.

[0032]

Embodiment 4

[0033]

[Table 5]

An amino acid having the above composition, 222 g of soybean oil (manufactured by NOF Corporation) as a fat, and soybean lecithin (Epiclon 100; manufactured by Nippon Siebel-Hegner) as an emulsifier
10 g and sucrose fatty acid ester (DK-F160;
Using 30 g of Daiichi Kogyo Seiyaku Co., Ltd., HLB = 15), 920 g of the fatty acid amino acid powder of the present invention in the same manner as in Example 1.
(100% = 1025 g).

[0035]

Embodiment 5

[0036]

[Table 6]

The amino acid having the above composition, 200 g of soybean oil (manufactured by NOF Corporation) and 100 g of corn oil (manufactured by NOF Corporation) as fats, 15 g of soybean lecithin (Epiclone 100; manufactured by Nippon Sebel Hegner Company) as an emulsifier, Example 1 Using 50 g of sugar fatty acid ester (DK-F160; manufactured by Daiichi Kogyo Seiyaku Co., HLB = 15) and 10 g of (DK-F90; manufactured by Daiichi Kogyo Seiyaku Co., Ltd., HLB = 9.5), Example 1
The fatty acid amino acid powder of the present invention (1060 g (10
0% = 1176 g).

[0038]

Embodiment 6

[0039]

[Table 7]

The amino acid having the above composition, 150 g of soybean oil (manufactured by NOF Corporation) as fat and MCT (Panasate 8)
10; Nippon Yushi Co., Ltd.) 150 g, soybean lecithin (Epiclon 100; Nippon Siebel Hegner) 20 g and sucrose fatty acid ester (DK-F1) as emulsifiers
60; manufactured by Dai-ichi Kogyo Seiyaku Co., Ltd., HLB = 15) Using 40 g of the fatty acid amino acid powder 11 of the present invention in the same manner as in Example 1
40 g (100% = 1262 g) were obtained.

[0041]

Embodiment 7

[0042]

[Table 8]

An amino acid having the above composition, 220 g of soybean oil (manufactured by NOF Corporation) and 110 g of corn oil (manufactured by NOF Corporation) as fats, 13 g of soybean lecithin (Epiclon 100; manufactured by Nippon Sebel Hegner Company) as an emulsifier, Example 1 Using 30 g of sugar fatty acid ester (DK-F160; manufactured by Daiichi Kogyo Seiyaku Co., HLB = 15) and 10 g of (DK-F90; manufactured by Daiichi Kogyo Seiyaku Co., Ltd., HLB = 9.5), Example 1
1160 g of the fatty acid amino acid powder of the present invention (10
0% = 1285 g).

[0044]

Embodiment 8

[0045]

[Table 9]

The amino acid having the above composition, 175 g of rice oil (manufactured by Nisshin Oil Co., Ltd.) as fat, 10 g of soybean lecithin (Epiclon 100; manufactured by Nippon Sebel Hegner) as an emulsifier, and sucrose fatty acid ester (DK-F160;
705 g of fatty acid amino acid powder of the present invention using 20 g of Daiichi Kogyo Seiyaku Co., Ltd., HLB = 15) in the same manner as in Example 1.
(100% = 784 g) was obtained.

[0047]

Embodiment 9

[0048]

[Table 10]

An amino acid having the above composition, 222 g of soybean oil (manufactured by NOF Corporation) as a fat and soybean lecithin (Epiclon 100; manufactured by Nippon Siebel Hegner) as an emulsifier
10 g and sucrose fatty acid ester (DK-F160;
910 g of fatty acid amino acid powder of the present invention in the same manner as in Example 1 using 30 g of Daiichi Kogyo Seiyaku Co., Ltd., HLB = 15)
(100% = 1008g) was obtained.

[0050]

Example 10 Fatty amino acid powder 5 obtained in Example 1
10 g, granulated dextrin (OMP; manufactured by Matsutani Chemical Co., Ltd.) 1
800 g, and a mixture of minerals and vitamins having the following composition in the above-mentioned granulated dextrin (100 g), mixed and homogenized, sealed in a 25-bag aluminum laminate film container under a nitrogen atmosphere, and powdered according to the present invention. A nutritional composition (about 400 kcal / bag) was obtained.

Mineral potassium chloride 18 (g) Calcium glycerophosphate 26.22 Magnesium sulfate 15 Manganese sulfate 0.055 Zinc sulfate 0.3 Iron sulfate 0.3 Copper sulfate 0.04 Potassium sorbate 2.5 ・ Retinol vitamin palmitate 20000 IU bisbenthamine 22 mg riboflavin 18 mg pyridoxine hydrochloride 24.5 mg cyanocobalamin 0.025 mg sodium ascorbate 1125 mg cholecalciferol 2000 IU tocopherol acetate 200 mg phytonadione 10 mg nicotinamide 200 mg folic acid 2 mg calcium pantothenate 8 mg calcium pantothenate

[0052]

Example 11 Fatty amino acid powder 5 obtained in Example 4
Except for using 15 g, a powder nutrition composition of the present invention (about 400 kcal / bag) was obtained in the same manner as in Example 10.

[0053]

Example 12 Fatty amino acid powder 5 obtained in Example 9
A powdered nutritional composition of the present invention (about 400 kcal / bag) was obtained in the same manner as in Example 10 except that 05 g was used.

[0054]

Example 13 Fatty amino acid powder 3 obtained in Example 8
95 g, granulated dextrin (OMP; manufactured by Matsutani Chemical Co., Ltd.) 7
40 g, and a mixture of minerals and vitamins having the following composition in 40 g of the above granulated dextrin uniformly mixed and homogenized, and sealed in a 25 bag made of aluminum laminated film under nitrogen purging to obtain a powder of the present invention. A nutritional composition (about 200 kcal / bag) was obtained.

Mineral potassium chloride 4.7 g Calcium glycerophosphate 7.6 g Magnesium sulfate 5.1 g Manganese sulfate 0.02 g Zinc sulfate 0.1 g Copper sulfate 0.13 g Sodium dihydrogen phosphate 4.9 g Sodium ferrous citrate 0 0.3g Potassium iodide 0.3mg ・Vitamin retinol palmitate 11650IU Ergocalciferol 1165IU Bisbenthamine 3.6mg Riboflavin 3.9mg Pyridoxine hydrochloride 6.1mg Cyanocobalamin 0.013mg Sodium ascorbate 173mg Tocopherol acetate 233mg Phytodione nicotine Amide 38mg Folic acid 1.25mg Calcium pantothenate 30mg Biotin 0.625mg Choline bitartrate 308mg

[0056]

Comparative Example 1 600 g of dextrin (manufactured by Matsutani Chemical Co., Ltd.) was added to and dissolved in 5000 ml of purified water.

Next, 10 g of soybean lecithin (Epiclon 100; manufactured by Nippon Siebel-Hegner) was heated and dissolved in 222 g of soybean oil (manufactured by NOF Corporation), and sucrose fatty acid ester (DK-F160; manufactured by Daiichi Kogyo Seiyaku Co., Ltd.) HLB = 15)
30 g was heated and dissolved in 1000 ml of purified water, and the three liquids were mixed and spray-dried in the same manner as in Example 1 to obtain 780 g of powder.
(100% = 862 g).

To 430 g of the obtained powder, 1500 g of granulated dextrin and an amino acid mixture (however,
/ 2 times the amount), and a mixture of minerals and vitamins having the same composition as in Example 10 mixed uniformly in 100 g of granulated dextrin to obtain a powdered nutritional composition.

[0059]

Comparative Example 2 3800 g of dextrin (manufactured by Matsutani Chemical Co., Ltd.) in 5000 ml of purified water, an amino acid mixture having the same composition as in Example 1, minerals and vitamins (provided that the amount of minerals and vitamins is twice the composition of Example 10) ) Was added and dissolved by heating. Next, 222 g of soybean oil (manufactured by NOF Corporation)
Then, 10 g of soybean lecithin (Epiclon 100; manufactured by Nippon Sebel Hegner Co., Ltd.) was dissolved by heating, and sucrose fatty acid ester (DK-F160; manufactured by Daiichi Kogyo Seiyaku Co., Ltd., HLB = 15)
30 g was heated and dissolved in 1000 ml of purified water, and the three liquids were mixed and spray-dried in the same manner as in Example 1 to obtain a powdered nutritional composition.

[0060]

[Physical test] The powder nutrition composition of the present invention obtained in Example 10 and the powder nutrition composition obtained in Comparative Examples 1 and 2 were tested in the following manner.

That is, the appearance of the powder was observed immediately after the production. Next, 250 g of each was placed in an enteral administration bag (made of polyvinyl chloride), 880 ml of water was added, and the mixture was shaken for about 1 minute, and the state of dissolution was observed. Further, the emulsified state of the liquid was visually observed, and the size of the emulsified particles was measured with a laser particle analyzer (manufactured by Otsuka Electronics Co., Ltd.). Further, the mixture was allowed to stand at room temperature for 48 hours, and then the state of the liquid was visually observed.

The results are shown in Table 1.

[0063]

[Table 11]

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁶ identification code FI A61K 47/24 A61K 47/26 H 47/26 9/14 G (58) Investigated field (Int.Cl. ⁶ , DB name) A61K 31/23 A61K 9/14 A61K 31/195 A61K 31/70 A61K 47/14 A61K 47/24 A61K 47/26 CA (STN)

Claims (2)

(57) [Claims] 1. A Tsu spray-dried powder product der of the emulsified oil-in-water type emulsion fat in the amino acid aqueous solution in the presence of an emulsifier
The emulsifier is sucrose fatty acid ester and polyglycerol
Or at least one selected from fatty acid esters
And a mixture of lecithin and HLB of 9-16.
The total weight of fat and amino acids
2.5 to 10% by weight of the fat and the amino acid
Fatty acid amino acid powder having a weight ratio of 1: 1.5 to 4.0
Powder and a ratio of 1.5 to 5.0 g with respect to 1 g of the powder.
Powder granules, comprising a granulated sugar
Nourishing composition . 2. A powder according to claim 1 amino acid aqueous solution is one that further containing vitamins and / or minerals
Nutrition composition .