JPH07147932A - Liquid high-energy food - Google Patents

Abstract

PURPOSE:To obtain a liquid high-energy food for oral administration-tube administration, containing a protein (hydrolyzate), a lipid, a vitamin, a mineral and a specific glucide, maintaining low viscosity and low osmotic pressure, being readily administered through a tube. CONSTITUTION:This liquid high-energy food contains (A) a dispersible finely granulated protein or its hydrolyzate, (B) an edible lipid, (C) a vitamin, (D) a mineral and (E) a dextrin having 10-25, preferably 12-20 DE value. The liquid high-energy food has sufficient viscosity and osmotic pressure to be readily administered through a tube even in a high concentration (high energy) exceeding 1.2kcal/ml.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid high-energy food for oral or tube administration.

[0002]

2. Description of the Related Art At present, there are powder type and liquid type concentrated liquid foods used in hospitals and the like, but liquid type foods have been favored because of easy handling. There is. Generally, liquid type products have emulsion stability that can withstand room temperature storage for several months, tube fluidity that can pass through a thin tube in a short time, low osmotic pressure to reduce side effects such as diarrhea, and good flavor. Is required. However, there is no liquid high-energy food for oral and tube use which has both good tube fluidity and low osmotic pressure and enables efficient energy supply. Also, with the current powder-type concentrated liquid food, when trying to prepare a solution with a concentration exceeding 1.2 Kcal / ml, it is not easy to dissolve, and the viscosity becomes too high, and sufficient tube fluidity may not be obtained. In addition, the osmotic pressure becomes high and causes diarrhea, which makes it difficult to use at high concentration.

[0003]

In conventional concentrated liquid foods, soluble proteins, protein hydrolysates or free amino acid mixtures have been used as nitrogen sources (protein sources).
Therefore, when the nitrogen source is soluble protein (fibrous protein), sufficient NPC / N (non-protein energy nitrogen ratio)
In order to obtain the protein, a large amount of high molecular weight protein must be dissolved, resulting in high viscosity. Therefore, it is necessary to reduce the molecular weight of the sugar in order to obtain the tube fluidity and reduce the overall viscosity, and DE (dextrin equivalent) is required.
High value dextrins have been used. However, if a dextrin having a too high DE value is used, the osmotic pressure becomes high, causing diarrhea and the like, and it is difficult to make a high-concentration product exceeding 1.2 Kcal / ml. When the nitrogen source was a soluble protein (globular protein), high-concentration protein was susceptible to thermal denaturation, and heat sterilization in liquid form was difficult. Further, when the nitrogen source is a protein hydrolyzate or a mixture of free amino acids, it is necessary to use dextrin having a low DE value because the nitrogen source exhibits a high osmotic pressure.
If the value of dextrin is used, the viscosity of the solution becomes too high and it becomes difficult to administer it through the tube. Therefore, in this case as well, there is a limit to making a product with high concentration (high energy).

[0004]

In order to solve these problems, the present invention utilizes a protein source containing dispersible fine particle protein as a nitrogen source (eg milk protein containing fine particle casein) as a nitrogen source during heat sterilization. Prevents denaturation, and has a DE value of 10-2
By using dextrin of No. 5, it has a low osmotic pressure while maintaining a low viscosity, and it has a viscosity that allows easy tube administration even at high concentrations (high energy) exceeding 1.2 Kcal / ml and causes diarrhea. It was found that a liquid high-energy food for oral / tuber administration can be obtained by suppressing the osmotic pressure, which has led to the present invention described below.

(1) A liquid high-energy food containing protein or its decomposition product, sugars, lipids, vitamins and minerals as main components and having high energy. (2) 1.2 Kcal / ml or more, more preferably 1.5 Kcal / ml
Above, More preferably, the liquid high energy food according to (1) above, which has a high energy of 2.0 Kcal / ml or more. (3) The above (1) containing a dispersible particulate protein as a protein source
And the liquid high-energy food according to (2). (4) The liquid high-energy food according to (1) or (2) above, wherein the sugar source is dextrin having a DE value of 10 to 25. (5) The liquid high energy food according to the above (1) to (3), which has a protein content of 42.8 mg / ml or more, more preferably 53.5 mg / ml or more, and further preferably 71.4 mg / ml or more.

In the present invention, dispersible particulate protein is used as the protein source. The dispersible fine particle protein is an insoluble protein dispersed in a colloidal form, and specific examples thereof include casein particles. Specifically, a naturally-occurring protein mixture containing the dispersible fine particle protein from the beginning or containing the dispersible fine particle protein after treatment with an enzyme or the like can be used. In particular, in the present invention, Lactose-free and whey protein concentrate are preferably used. The dispersible fine particle protein can suppress protein denaturation during heat sterilization. The protein content is 42.8 mg / ml or more, more preferably 53.5 mg / ml or more, further preferably 71.4 m
More than g / ml.

In the present invention, dextrin is used as a sugar source, and dextrin having a DE value of 10 to 25 is preferable, and dextrin having a DE value of 12 to 20 is particularly preferable. If the DE value is 10 or less, the viscosity will be high, which is not preferable when administered using a tubular body such as a tube, and if it is 25 or more, the osmotic pressure will be high. The concentration of dextrin is 170 to 300 mg / ml, more preferably 210 to 270 mg / ml. In addition, oligosaccharides, disaccharides, monosaccharides and the like may be mixed in any amount as other sugars and used.

Examples of lipids include vegetable oils such as soybean oil and corn oil, animal fats such as tallow and milk fat, and MCT.
Examples thereof include (neutral fat), but not particularly limited as long as they are generally used for food.

By mixing the above-mentioned proteins, sugars and lipids in the above-mentioned amounts, the liquid food of the present invention having a low viscosity, a low osmotic pressure and a high energy can be obtained. In addition, a processed product such as milk or soy milk may be used as a product containing the above-mentioned nutrients from the beginning, instead of a mixture of each material.

In the present invention, if necessary, a lipid,
Nutrients such as vitamins and minerals may be added. As vitamins, vitamins A, B ₁ , B ₂ , B ₆ , B ₁₂ ,
C, D, E, nimachine, pantothenic acid, folic acid and the like can be mentioned. Examples of minerals include sodium, potassium, calcium, magnesium and iron. In addition, vitamin K, biotin, choline, zinc, manganese,
Copper, iodine, etc. may be added. The content of these nutrients is not particularly limited.

The liquid high-energy food of the present invention can be obtained by using a high-pressure homogenizer after adding an emulsifier to the above-mentioned protein, sugar and each nutrient, adding an arbitrary amount of water and mixing them. Further, after this, high temperature short time sterilization is performed if necessary.

Examples of the emulsifier include lecithin, lysolecithin, decaglycerin fatty acid ester, decaglycerin tartaric acid monoglyceride, etc., but are not particularly limited as long as they are used for food. The emulsifier content is in the range of 0.01 to 0.2 with respect to 1 part of fats and oils, and an arbitrary amount is mixed.

The liquid high energy food of the present invention has a low osmotic pressure of 600 mOsm or less and a low viscosity of 40 cp or less at 25 ° C. when prepared at a high concentration of 2 Kcal / ml. Further, the liquid high energy food of the present invention is NPC / N.
The value is 120-200.

In the present invention, the osmotic pressure is OsmometerModel, Advanced Company, GRYOMATIC (registered trademark).
3CII was used to measure the freezing point, and the viscosity was measured with a B-type viscometer (Shibaura Kogyo Co., Ltd., Bismetron). The energy (calorie) value is the total weight of the protein source ×
4. The conversion formula of total weight x4 for sugar and total weight x9 for lipid was calculated.

[0015]

EXAMPLES The present invention will be described in more detail with reference to Examples, Comparative Examples and Test Examples. (Example 1) In 6000 ml of warm water, 882 g of milk protein concentrate (TMP: Morinaga Milk Industry Co., Ltd.), 48 g of lysolecithin (emulsifier 1), 11 g of decaglycerin fatty acid ester (emulsifier 2), 2550 g of dextrin (Glister P). (DE value 15): Matsutani Chemical Co., Ltd.) was dissolved and dispersed using TK Homomixer (manufactured by Tokushu Kika Kogyo).

25 g of decaglycerin tartaric acid monoglyceride (emulsifier 3) was dissolved in 758 g of soybean oil. This blended lipid is mixed with the above aqueous solution, and a fat-soluble vitamin and a water-soluble vitamin mix (composition shown in Table 1) are further added, followed by pre-emulsification using TK and a homomixer, and then water added to 10,000 ml. I got up.

[0017]

[Table 1]

This pre-emulsified liquid was homogenized using a high-pressure homogenizer manufactured by Manton-Gorlin Co., Ltd., two-step homogenization of 100 kg / cm ^{2 in} the first step and 300 kg / cm ^{2 in} the second step was performed four times to obtain an emulsion. This emulsion was sterilized at high temperature for a short time (140 ° C., 4 seconds) and then aseptically filled to obtain a high energy food of 2.0 Kcal / ml. This liquid high energy food is 2.0 Kcal /
It has a viscosity of 1 at 25 ℃ even under high concentration
It is 7.0 cp, and the osmotic pressure is as low as 442 mOsm,
The low sweetness made it very easy to drink.

The liquid nutritional food can be adjusted to a concentration of 1.5 Kcal / ml by diluting it with water, and the protein concentration at this time is 53.6 mg / ml. 1.5K
NPC / N = 150 when adjusted at high concentration of cal / ml or more
In order to maintain the protein concentration, it is necessary to adjust the protein concentration to 53.6 mg / ml or more. Table 2 shows the composition of the obtained high-energy food.

[0020]

[Table 2]

Test Example 1 Milk protein concentrate (TMP, Example 1), soluble fibrous protein (casein Na, Comparative Example 1), soluble globular protein (whey protein, Comparative Example 2) were used as nitrogen sources. ) And the peptide (whey hydrolyzate, Comparative Example 3) were used to obtain Test Examples 1 to 3. The manufacturing method is the same as in Example 1 except that the protein source is changed. The respective viscosities (25 ° C.) and osmotic pressures are as shown in Table 3.

[0022]

[Table 3]

The casein Na and the whey peptide showed high viscosities, exceeding the target viscosities. Also, whey peptides show high osmotic pressure and are not suitable as protein sources. Milk protein concentrate and whey protein showed suitable values in osmotic pressure and viscosity, but whey protein formed a heat gel at a high concentration and could not be heat sterilized. Therefore, Example 1 was the most suitable as a protein source.

Test Example 2 11 kinds of dextrins having different DE values (Example 1, Test Examples 1 to 1) were used as kinds of sugar sources.
The test of viscosity and osmotic pressure of 10) was conducted. The manufacturing method of the test example is the same as that of the example 1 except that the kind of dextrin is changed. The results are shown in Table 4.

[0025]

[Table 4]

As shown in the results, the DE value of dextrin must be 25 or less in order to set the osmotic pressure to 600 mOsm or less, and the DE value of dextrin must be set to 40 or less in the viscosity (25 ° C.). The value must be 10 or greater.

[0027]

INDUSTRIAL APPLICABILITY According to the present invention, 1.2 Kcal / ml is obtained by mixing dispersible fine particle protein such as milk protein containing fine particle casein, dextrin having a DE value of 10 to 25, and other nutrients such as lipids, vitamins and minerals. A liquid high-energy food prepared with a high concentration exceeding 0.1 is obtained. The high-concentration liquid high-energy food of the present invention is capable of ingesting a large amount of energy in a small amount, and therefore has a decreased appetite, cannot eat a large amount of food at a time, and consumes a large amount of food in a short time. It is suitable for tube feeding where you want to administer energy.

Further, this high-energy food is, for example, 2
Even a high-concentration Kcal / ml preparation has low viscosity and low osmotic pressure, so it can be administered by tube without side effects such as diarrhea, and has low viscosity and excellent flowability when taken orally. It has the advantage of being very easy to drink. It also has excellent stability during sterilization.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁶ Identification number Office reference number FI technical display location A61K 33/00 9454-4C 38/00 A61K 37/18 37/22

Claims (1)

[Claims] 1. A liquid high-energy food containing protein or a degradation product thereof, sugar, lipid, vitamin and mineral, wherein dextrin having a DE value of 10 to 25 is used as sugar.