JP2719377B2 - ９α―ヒドロキシ―１７―ケトステロイドの微生物学的製法 - Google Patents

９α―ヒドロキシ―１７―ケトステロイドの微生物学的製法

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Publication number
JP2719377B2
JP2719377B2 JP63325731A JP32573188A JP2719377B2 JP 2719377 B2 JP2719377 B2 JP 2719377B2 JP 63325731 A JP63325731 A JP 63325731A JP 32573188 A JP32573188 A JP 32573188A JP 2719377 B2 JP2719377 B2 JP 2719377B2
Authority
JP
Japan
Prior art keywords
dione
hydroxy
mycobacterium
hydroxyandrost
medium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP63325731A
Other languages
English (en)
Japanese (ja)
Other versions
JPH022395A (ja
Inventor
スレイクハイス ハルメン
フリートリッヒ マルクス アルチュール
Original Assignee
ルーセル ウクラーフ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ルーセル ウクラーフ filed Critical ルーセル ウクラーフ
Publication of JPH022395A publication Critical patent/JPH022395A/ja
Application granted granted Critical
Publication of JP2719377B2 publication Critical patent/JP2719377B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/005—Degradation of the lateral chains at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/863—Mycobacterium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
JP63325731A 1987-12-23 1988-12-23 ９α―ヒドロキシ―１７―ケトステロイドの微生物学的製法 Expired - Lifetime JP2719377B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP87202619 1987-12-23
EP87202619.0 1987-12-23

Publications (2)

Publication Number Publication Date
JPH022395A JPH022395A (ja) 1990-01-08
JP2719377B2 true JP2719377B2 (ja) 1998-02-25

Family

ID=8197730

Family Applications (1)

Application Number Title Priority Date Filing Date
JP63325731A Expired - Lifetime JP2719377B2 (ja) 1987-12-23 1988-12-23 ９α―ヒドロキシ―１７―ケトステロイドの微生物学的製法

Country Status (6)

Country Link
US (1) US5166055A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP0322081B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP2719377B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (1) DE3876769T2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ES (1) ES2052693T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GR (1) GR3006578T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2052693T3 (es) * 1987-12-23 1994-07-16 Roussel Uclaf Preparacion microbiologica de 9-alfa-hidroxi-17-ceto-esteroides.
US5298398A (en) * 1987-12-23 1994-03-29 Gist-Brocades Nv Preparation of 9-α-hydroxy-17-keto steroids using Mycobacterium species CBS 482.86
EP0496854B1 (de) * 1990-08-18 2000-03-15 Schering Aktiengesellschaft Verfahren zur Herstellung von 20-METHYL-5,7-PREGNADIEN-3$g(b),21-DIOL-DERIVATIVEN
CA2069956C (en) * 1990-08-18 2001-05-08 Alfred Weber Process for the production of 17-oxosteroids
US5472854A (en) * 1990-08-18 1995-12-05 Schering Aktiengesellschaft Process for the production of 17-oxosteroids via the fermentative oxidation of 17β-hydroxysteroids by Mycobacterium
ES2347027T3 (es) 1998-05-22 2010-10-22 The Board Of Trustees Of The Leland Stanford Junior University Moleculas bifuncionales y terapias basadas en las mismas.
GB0003231D0 (en) * 2000-02-11 2000-04-05 Medi Cult As Cell culture media
KR100418657B1 (ko) * 2001-10-16 2004-02-11 주식회사 엘지생명과학 마이코박테리움 에스피를 사용하는9-알파-하이드록시-안드로스트-4-엔-3,17-디온의 제조방법
DK1889198T3 (da) 2005-04-28 2015-02-09 Proteus Digital Health Inc Farma-informatiksystem
WO2007035716A2 (en) 2005-09-16 2007-03-29 Raptor Pharmaceutical Inc. Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
CN104208718B (zh) 2009-02-20 2017-12-29 2-Bbb医疗股份有限公司 基于谷胱甘肽的药物递送系统
KR20190116576A (ko) 2009-05-06 2019-10-14 라보라토리 스킨 케어, 인크. 활성제-칼슘 포스페이트 입자 복합체를 포함하는 피부 전달 조성물 및 이들을 이용하는 방법
CN103613627B (zh) * 2013-11-20 2017-12-01 上海市农药研究所 生物转化生产雄烯二酮过程中食用级油的循环再利用方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE232167C (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) *
NL6513718A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1965-10-22 1967-04-24
NL6705450A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * 1965-10-22 1968-10-21
US3684657A (en) * 1970-05-11 1972-08-15 Searle & Co Selective microbiological degradation of steroidal 17-alkyls
US3759791A (en) * 1970-12-10 1973-09-18 Searle & Co Selective microbiological preparation of androst-4-ene-3,17-dione
US4035236A (en) * 1975-10-24 1977-07-12 The Upjohn Company Process for preparing 9α-hydroxyandrostenedione
US4293645A (en) * 1976-03-01 1981-10-06 The Upjohn Company Process for preparing androsta-1,4-diene-3,17-dione and androst-4-ene-3,17-dione
JPS5326391A (en) * 1976-07-26 1978-03-11 Kanegafuchi Chem Ind Co Ltd Preparation of l-lysine by fermentation
US4345033A (en) * 1976-10-22 1982-08-17 The Upjohn Company Mycobacterium fortuitum mutant
US4226936A (en) * 1977-10-21 1980-10-07 The Upjohn Company Process for preparing 9α-OH BN alcohol
AT362086B (de) * 1978-04-17 1981-04-27 Henkel Kgaa Verfahren zur herstellung von 17-c-steroid- -alpha-propionsaeureverbindungen durch mikro- biellen seitenkettenabbau an 17-c-seitenketten- -steroidsubstraten
US4358538A (en) * 1978-08-07 1982-11-09 The Upjohn Company Mycobacterium fortuitum mutant
JPS5585397A (en) * 1978-12-21 1980-06-27 Mitsubishi Chem Ind Ltd Microbiological preparation of 9alpha-hydroxyandrostenedione
ATE3991T1 (de) * 1979-10-26 1983-07-15 Schering Aktiengesellschaft Berlin Und Bergkamen Verfahren zur herstellung von 9-alpha-hydroxy-4- androsten-3,17-dion.
JPS578794A (en) * 1980-06-17 1982-01-18 Mitsubishi Chem Ind Ltd Preparation of androstane-type steroid
US4397947A (en) * 1981-06-12 1983-08-09 G. D. Searle & Co. Microbial process for 9α-hydroxylation of steroids
JPS60114187A (ja) * 1983-11-25 1985-06-20 Agency Of Ind Science & Technol 新規微生物
US5352809A (en) * 1986-10-10 1994-10-04 Gist-Brocades N.V. 9-alpha-hydroxy steroids, process for their preparation, process for the preparation of the corresponding 9(11)-dehydro derivatives and pharmaceutical preparations containing such steroids
HU196627B (en) * 1986-11-18 1988-12-28 Gyogyszerkutato Intezet Microbiological process for producing y alpha-hydroxy-4-androstene-3,17-dione
ES2052693T3 (es) * 1987-12-23 1994-07-16 Roussel Uclaf Preparacion microbiologica de 9-alfa-hidroxi-17-ceto-esteroides.

Also Published As

Publication number Publication date
JPH022395A (ja) 1990-01-08
DE3876769T2 (de) 1993-06-09
DE3876769D1 (de) 1993-01-28
ES2052693T3 (es) 1994-07-16
EP0322081B1 (en) 1992-12-16
EP0322081A1 (en) 1989-06-28
US5166055A (en) 1992-11-24
GR3006578T3 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1993-06-30

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Publication Publication Date Title
US4035236A (en) Process for preparing 9α-hydroxyandrostenedione
JP2719377B2 (ja) ９α―ヒドロキシ―１７―ケトステロイドの微生物学的製法
US4029549A (en) Process of producing 9α-hydroxy-3-ketobisnorchol-4-en-22-oic with mycobacterium fortuitum
US4345029A (en) Mycobacterium phlei mutants convert sterols to androsta-1,4-diene-3,17-dione and androsta-4-ene-3,17-dione
US4293644A (en) Process for preparing androst-4-ene-3,17-dione
US4039381A (en) Composition of matter and process
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JPS6141547B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
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