ES2052693T3 - Preparacion microbiologica de 9-alfa-hidroxi-17-ceto-esteroides. - Google Patents

Preparacion microbiologica de 9-alfa-hidroxi-17-ceto-esteroides.

Info

Publication number
ES2052693T3
ES2052693T3 ES88202997T ES88202997T ES2052693T3 ES 2052693 T3 ES2052693 T3 ES 2052693T3 ES 88202997 T ES88202997 T ES 88202997T ES 88202997 T ES88202997 T ES 88202997T ES 2052693 T3 ES2052693 T3 ES 2052693T3
Authority
ES
Spain
Prior art keywords
steroids
ceto
alpha
hydroxy
diona
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88202997T
Other languages
English (en)
Inventor
Harmen Slijkhuis
Arthur Friedrich Marx
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Application granted granted Critical
Publication of ES2052693T3 publication Critical patent/ES2052693T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P33/00—Preparation of steroids
    • C12P33/005—Degradation of the lateral chains at position 17
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/863—Mycobacterium

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

ESTEROIDES 9 - ALFA - HIDROXI - 17 CETO SE PREPARAN POR FERMENTACION DE ESTEROIDES QUE TIENEN UNA CADENA DE C17 DE 5 A 10 C INCLUSIVE, CON LA NUEVA ESPECIE MICOBACTERIUM SPECIES CBS482.86. EMPEZANDO DE VARIOS SUSTRATOS QUE CONTIENEN UNA CADENA DE 5 A 10 C SE OBTIENE UN C17 - 9 ALFA - HIDROXIANDROST - 4 - ENO - 3,17 - DIONA, 7ALFA, 9ALFA, 12ALFA, TRIHIDROXIANDROST - 4 - ENO - 3, 17 - DIONA O 9ALFA - HIDROXIANDROST 4,11 - DIENO - 3,17 - DIONA EN ALTA PRODUCCION. LOS COMPUESTOS RESULTANTES SON INTERMEDIARIOS UTILES EN LA SINTESIS DE ESTEROIDES IMPORTANTES TERAPEUTICAMENTE, PARTICULARMENTE COTICOSTEROIDES.
ES88202997T 1987-12-23 1988-12-23 Preparacion microbiologica de 9-alfa-hidroxi-17-ceto-esteroides. Expired - Lifetime ES2052693T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP87202619 1987-12-23

Publications (1)

Publication Number Publication Date
ES2052693T3 true ES2052693T3 (es) 1994-07-16

Family

ID=8197730

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88202997T Expired - Lifetime ES2052693T3 (es) 1987-12-23 1988-12-23 Preparacion microbiologica de 9-alfa-hidroxi-17-ceto-esteroides.

Country Status (6)

Country Link
US (1) US5166055A (es)
EP (1) EP0322081B1 (es)
JP (1) JP2719377B2 (es)
DE (1) DE3876769T2 (es)
ES (1) ES2052693T3 (es)
GR (1) GR3006578T3 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5298398A (en) * 1987-12-23 1994-03-29 Gist-Brocades Nv Preparation of 9-α-hydroxy-17-keto steroids using Mycobacterium species CBS 482.86
EP0322081B1 (en) * 1987-12-23 1992-12-16 Roussel-Uclaf Microbiological preparation of 9-alpha-hydroxy-17-keto steroids
DE59108700D1 (de) * 1990-08-18 1997-06-12 Schering Ag Verfahren zur herstellung von 17-oxosteroiden
US5472854A (en) * 1990-08-18 1995-12-05 Schering Aktiengesellschaft Process for the production of 17-oxosteroids via the fermentative oxidation of 17β-hydroxysteroids by Mycobacterium
EP0496854B1 (de) * 1990-08-18 2000-03-15 Schering Aktiengesellschaft Verfahren zur Herstellung von 20-METHYL-5,7-PREGNADIEN-3$g(b),21-DIOL-DERIVATIVEN
ATE473759T1 (de) 1998-05-22 2010-07-15 Univ Leland Stanford Junior Bifunktionelle moleküle sowie darauf basierende therapien.
GB0003231D0 (en) * 2000-02-11 2000-04-05 Medi Cult As Cell culture media
KR100418657B1 (ko) * 2001-10-16 2004-02-11 주식회사 엘지생명과학 마이코박테리움 에스피를 사용하는9-알파-하이드록시-안드로스트-4-엔-3,17-디온의 제조방법
EP2392258B1 (en) 2005-04-28 2014-10-08 Proteus Digital Health, Inc. Pharma-informatics system
US9062126B2 (en) 2005-09-16 2015-06-23 Raptor Pharmaceuticals Inc. Compositions comprising receptor-associated protein (RAP) variants specific for CR-containing proteins and uses thereof
AU2010216512B2 (en) 2009-02-20 2016-06-30 2-Bbb Medicines B.V. Glutathione-based drug delivery system
WO2010129819A2 (en) 2009-05-06 2010-11-11 Laboratory Skin Care, Inc. Dermal delivery compositions comprising active agent-calcium phosphate particle complexes and methods of using the same
CN103613627B (zh) * 2013-11-20 2017-12-01 上海市农药研究所 生物转化生产雄烯二酮过程中食用级油的循环再利用方法

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE232167C (es) *
NL6705450A (es) * 1965-10-22 1968-10-21
NL6513718A (es) * 1965-10-22 1967-04-24
US3684657A (en) * 1970-05-11 1972-08-15 Searle & Co Selective microbiological degradation of steroidal 17-alkyls
US3759791A (en) * 1970-12-10 1973-09-18 Searle & Co Selective microbiological preparation of androst-4-ene-3,17-dione
US4035236A (en) * 1975-10-24 1977-07-12 The Upjohn Company Process for preparing 9α-hydroxyandrostenedione
US4293645A (en) * 1976-03-01 1981-10-06 The Upjohn Company Process for preparing androsta-1,4-diene-3,17-dione and androst-4-ene-3,17-dione
JPS5326391A (en) * 1976-07-26 1978-03-11 Kanegafuchi Chem Ind Co Ltd Preparation of l-lysine by fermentation
US4345033A (en) * 1976-10-22 1982-08-17 The Upjohn Company Mycobacterium fortuitum mutant
US4226936A (en) * 1977-10-21 1980-10-07 The Upjohn Company Process for preparing 9α-OH BN alcohol
AT362086B (de) * 1978-04-17 1981-04-27 Henkel Kgaa Verfahren zur herstellung von 17-c-steroid- -alpha-propionsaeureverbindungen durch mikro- biellen seitenkettenabbau an 17-c-seitenketten- -steroidsubstraten
US4358538A (en) * 1978-08-07 1982-11-09 The Upjohn Company Mycobacterium fortuitum mutant
JPS5585397A (en) * 1978-12-21 1980-06-27 Mitsubishi Chem Ind Ltd Microbiological preparation of 9alpha-hydroxyandrostenedione
ATE3991T1 (de) * 1979-10-26 1983-07-15 Schering Aktiengesellschaft Berlin Und Bergkamen Verfahren zur herstellung von 9-alpha-hydroxy-4- androsten-3,17-dion.
JPS578794A (en) * 1980-06-17 1982-01-18 Mitsubishi Chem Ind Ltd Preparation of androstane-type steroid
US4397947A (en) * 1981-06-12 1983-08-09 G. D. Searle & Co. Microbial process for 9α-hydroxylation of steroids
JPS60114187A (ja) * 1983-11-25 1985-06-20 Agency Of Ind Science & Technol 新規微生物
KR960010793B1 (ko) * 1986-10-10 1996-08-08 루쎌 위클라프 소시에떼 아노님 9-알파-히드록시 스테로이드 및 그의 제조방법
HU196627B (en) * 1986-11-18 1988-12-28 Gyogyszerkutato Intezet Microbiological process for producing y alpha-hydroxy-4-androstene-3,17-dione
EP0322081B1 (en) * 1987-12-23 1992-12-16 Roussel-Uclaf Microbiological preparation of 9-alpha-hydroxy-17-keto steroids

Also Published As

Publication number Publication date
DE3876769T2 (de) 1993-06-09
GR3006578T3 (es) 1993-06-30
JP2719377B2 (ja) 1998-02-25
EP0322081A1 (en) 1989-06-28
JPH022395A (ja) 1990-01-08
EP0322081B1 (en) 1992-12-16
US5166055A (en) 1992-11-24
DE3876769D1 (de) 1993-01-28

Similar Documents

Publication Publication Date Title
ES2052693T3 (es) Preparacion microbiologica de 9-alfa-hidroxi-17-ceto-esteroides.
DK0405864T3 (da) Phospholipase A2-inhibitor, mikroorganismer der producerer inhibitoren og fremgangsmåder til den fremstilling
FI906438A0 (fi) Menetelmä uusien, terapeuttisesti käyttökelpoisten A-nor-steroidi-3-karboksyylihappojohdannaisten valmistamiseksi
NZ192992A (en) Production of ethanol by fermentation
AU7237687A (en) Use of malonic acid derivative compounds for retarding plant growth
BG92810A (bg) Метод за получаване на 23-(с долу 1-6 алкилоксим)- ll-f 28249
ATE73850T1 (de) Verfahren zur herstellung von 2-keto-dglukars|ure.
FR2374302A1 (fr) Nouvelles halogenethyl-sulfones, leur procede de preparation et leur application comme substances de croissance des plantes
ATE10806T1 (de) Verfahren zur herstellung von hepatitis boberfl[chenantigen.
FI881038A (fi) Ny kristallisk cefadroxil och foerfarande foer dess framstaellning.
ES8106730A1 (es) Un procedimiento para preparar benzoxazepinas.
IT1210926B (it) Derivati della 1-metil-5-nitro-imidazolina e composizioni terapeutiche che li comprendono come principio attivo.
GB1530921A (en) Desacylpepsidine and the preparation thereof
SU581915A1 (ru) Способ производства энтомопатогенных микробных препаратов
BG34461A3 (en) Method of obtaining derivatives of 7 beta-amino- thiazolylacetamido-3-cephem-4-carbonic acid
JPS5414983A (en) Tunicamine derivative and its preparation
DE69019591D1 (de) Phospholipase-A2-Inhibitor, Verfahren zu seiner Herstellung und diesen enthaltende pharmazeutische oder veterinäre Zusammensetzungen.
IE45609L (en) Process for the preparation of prostaglandins
DE69204766D1 (de) Verfahren zur Herstellung von Bicyclo(3.2.0)hept-2-en-7-onen.
JPS6429378A (en) Physiologically active substance and production thereof
JPS5561730A (en) Production of seed germ for mashroom cultivation
JPS5432693A (en) Preparation of l-threonine by fermentation
PH13568A (en) Use of cyclic esters to prepare 2,3-dichloro-4-(2-phenoyl)phenoxyacetic acid
JPS5599197A (en) Preparation of colistin heptapeptide
ES373314A1 (es) Procedimiento para la produccion de hormigon visto claro exento de manchas.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 322081

Country of ref document: ES