JP2684871B2 - 体液成分測定方法および測定装置 - Google Patents
体液成分測定方法および測定装置Info
- Publication number
- JP2684871B2 JP2684871B2 JP3139503A JP13950391A JP2684871B2 JP 2684871 B2 JP2684871 B2 JP 2684871B2 JP 3139503 A JP3139503 A JP 3139503A JP 13950391 A JP13950391 A JP 13950391A JP 2684871 B2 JP2684871 B2 JP 2684871B2
- Authority
- JP
- Japan
- Prior art keywords
- body fluid
- cell
- flow
- measuring
- liquid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 210000001124 body fluid Anatomy 0.000 title claims description 158
- 239000010839 body fluid Substances 0.000 title claims description 157
- 238000000034 method Methods 0.000 title claims description 28
- 239000007788 liquid Substances 0.000 claims description 40
- 238000005259 measurement Methods 0.000 claims description 30
- 239000003085 diluting agent Substances 0.000 claims description 18
- 238000011002 quantification Methods 0.000 claims description 12
- 238000007599 discharging Methods 0.000 claims description 11
- 239000000243 solution Substances 0.000 claims description 11
- 238000001514 detection method Methods 0.000 claims description 6
- 238000007865 diluting Methods 0.000 claims description 6
- 230000006837 decompression Effects 0.000 claims description 5
- 239000012530 fluid Substances 0.000 claims description 5
- 239000012895 dilution Substances 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 210000004027 cell Anatomy 0.000 description 73
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 19
- 239000008103 glucose Substances 0.000 description 19
- 210000003491 skin Anatomy 0.000 description 14
- 210000000416 exudates and transudate Anatomy 0.000 description 9
- 238000010586 diagram Methods 0.000 description 8
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 238000005070 sampling Methods 0.000 description 7
- 239000000126 substance Substances 0.000 description 6
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 4
- 238000012544 monitoring process Methods 0.000 description 4
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 3
- 239000007995 HEPES buffer Substances 0.000 description 3
- 239000002390 adhesive tape Substances 0.000 description 3
- 239000004202 carbamide Substances 0.000 description 3
- 125000006850 spacer group Chemical group 0.000 description 3
- 108010015776 Glucose oxidase Proteins 0.000 description 2
- 239000004366 Glucose oxidase Substances 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 230000003139 buffering effect Effects 0.000 description 2
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 2
- 235000019420 glucose oxidase Nutrition 0.000 description 2
- 229940116332 glucose oxidase Drugs 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 235000014655 lactic acid Nutrition 0.000 description 2
- 239000004310 lactic acid Substances 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052760 oxygen Inorganic materials 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 239000013060 biological fluid Substances 0.000 description 1
- 210000000601 blood cell Anatomy 0.000 description 1
- 229940109239 creatinine Drugs 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 230000005669 field effect Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 238000007410 oral glucose tolerance test Methods 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/44—Detecting, measuring or recording for evaluating the integumentary system, e.g. skin, hair or nails
- A61B5/441—Skin evaluation, e.g. for skin disorder diagnosis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N2001/028—Sampling from a surface, swabbing, vaporising
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
- G01N2001/1418—Depression, aspiration
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Biophysics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Optics & Photonics (AREA)
- Hydrology & Water Resources (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3139503A JP2684871B2 (ja) | 1991-05-16 | 1991-05-16 | 体液成分測定方法および測定装置 |
| EP92108157A EP0513789A2 (en) | 1991-05-16 | 1992-05-14 | Method and apparatus for detecting and determining components of body fluids |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3139503A JP2684871B2 (ja) | 1991-05-16 | 1991-05-16 | 体液成分測定方法および測定装置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH04341241A JPH04341241A (ja) | 1992-11-27 |
| JP2684871B2 true JP2684871B2 (ja) | 1997-12-03 |
Family
ID=15246805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP3139503A Expired - Fee Related JP2684871B2 (ja) | 1991-05-16 | 1991-05-16 | 体液成分測定方法および測定装置 |
Country Status (2)
| Country | Link |
|---|---|
| EP (1) | EP0513789A2 (en, 2012) |
| JP (1) | JP2684871B2 (en, 2012) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0824680B2 (ja) * | 1992-10-26 | 1996-03-13 | 日本電気株式会社 | 吸引浸出液採取装置 |
| JP2000502269A (ja) * | 1995-12-18 | 2000-02-29 | アボツト・ラボラトリーズ | 体液の抽出およびモニタリング |
| EP0812150A4 (en) * | 1995-12-28 | 1999-03-10 | Cygnus Therapeutic Systems | CONTINUOUS CONTROL OF A PHYSIOLOGICAL ANALYTE |
| US6009343A (en) * | 1996-02-23 | 1999-12-28 | Abbott Laboratories | Enhanced transdermal transport of fluid using vacuum |
| JP2964942B2 (ja) * | 1996-02-28 | 1999-10-18 | 日本電気株式会社 | 吸引浸出液採取装置 |
| JP2828064B2 (ja) * | 1996-09-20 | 1998-11-25 | 日本電気株式会社 | 吸引浸出液採取方法および装置 |
| JP3097600B2 (ja) * | 1997-05-30 | 2000-10-10 | 日本電気株式会社 | 角質層穿刺装置 |
| JP3087687B2 (ja) * | 1997-06-09 | 2000-09-11 | 日本電気株式会社 | 液体成分測定装置 |
| US8287483B2 (en) | 1998-01-08 | 2012-10-16 | Echo Therapeutics, Inc. | Method and apparatus for enhancement of transdermal transport |
| US7066884B2 (en) | 1998-01-08 | 2006-06-27 | Sontra Medical, Inc. | System, method, and device for non-invasive body fluid sampling and analysis |
| JP3109470B2 (ja) | 1998-03-11 | 2000-11-13 | 日本電気株式会社 | 角質層穿刺針及び角質層穿刺部材 |
| WO1999058050A1 (en) | 1998-05-13 | 1999-11-18 | Cygnus, Inc. | Signal processing for measurement of physiological analytes |
| US20040171980A1 (en) | 1998-12-18 | 2004-09-02 | Sontra Medical, Inc. | Method and apparatus for enhancement of transdermal transport |
| DE10003507B4 (de) | 2000-01-27 | 2004-06-03 | Knoll, Meinhard, Prof. Dr. | Vorrichtung und Verfahren zur Entnahme von Flüssigkeiten aus körpereigenem Gewebe und Bestimmung von Stoffkonzentrationen in dieser Flüssigkeit |
| US6537243B1 (en) | 2000-10-12 | 2003-03-25 | Abbott Laboratories | Device and method for obtaining interstitial fluid from a patient for diagnostic tests |
| FI20011918A0 (fi) * | 2001-10-01 | 2001-10-01 | Mirhava Ltd | Automaattinen verisuoni yhteyden hallintalaite |
| FR2866118B1 (fr) * | 2004-02-11 | 2007-10-19 | Hemodia | Dispositif de mesure instantanee et continue de substances en phase aqueuse |
| ATE407624T1 (de) * | 2004-03-05 | 2008-09-15 | Dilab I Lund Ab | System und verfahren für die automatische entnahme von flüssigkeitsproben |
| US20060094944A1 (en) | 2004-10-28 | 2006-05-04 | Sontra Medical Corporation | System and method for analyte sampling and analysis with error correction |
| US7432069B2 (en) | 2005-12-05 | 2008-10-07 | Sontra Medical Corporation | Biocompatible chemically crosslinked hydrogels for glucose sensing |
| NZ580179A (en) | 2007-03-07 | 2011-06-30 | Echo Therapeutics Inc | Transdermal analyte monitoring systems and methods for analyte detection |
| WO2008134545A1 (en) | 2007-04-27 | 2008-11-06 | Echo Therapeutics, Inc. | Skin permeation device for analyte sensing or transdermal drug delivery |
| EP2042096A1 (de) | 2007-09-27 | 2009-04-01 | F. Hoffmann-La Roche AG | Verteilvorrichtung für eine Körperflüssigkeitsprobe, Fluidentnahme- und infusionssystem sowie Verfahren zum Betreiben |
| CN102894981B (zh) * | 2012-09-26 | 2014-05-21 | 天津大学 | 基于微量采血的人体血糖浓度的连续高精度检测仪器 |
| CN109725169B (zh) * | 2018-12-26 | 2023-03-14 | 迪瑞医疗科技股份有限公司 | 一种尿液分析仪的液路系统及其控制方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE8201448L (sv) * | 1982-03-09 | 1983-09-10 | Walle Roald Franch | Forfarande och anordning for transmission av mindre provvetskevolymer |
| SE451894B (sv) * | 1986-08-15 | 1987-11-02 | Gambro Ab | Analyssystem innefattande medel for uttagning av blod, samt for ledning forbi en metelektrod, samt medel for tillforsel av utspednings- eller antikoaguleringsvetska |
| SE8703987D0 (sv) * | 1987-10-14 | 1987-10-14 | Sydkraft Ab | Forfarande och anleggning for framstellning av biogas |
| JPH0265846A (ja) * | 1988-08-31 | 1990-03-06 | Nec Corp | 吸引浸出液測定装置 |
| JPH02286132A (ja) * | 1989-04-28 | 1990-11-26 | Nec Corp | 血液成分測定装置および測定方法 |
| JP2630005B2 (ja) * | 1990-03-23 | 1997-07-16 | 日本電気株式会社 | 液体成分測定装置および測定方法 |
| JP2958367B2 (ja) * | 1990-09-28 | 1999-10-06 | 日本電気三栄株式会社 | 組織液吸引採取装置 |
| JPH04150836A (ja) * | 1990-10-16 | 1992-05-25 | Nec San-Ei Instr Co Ltd | 血糖測定装置 |
-
1991
- 1991-05-16 JP JP3139503A patent/JP2684871B2/ja not_active Expired - Fee Related
-
1992
- 1992-05-14 EP EP92108157A patent/EP0513789A2/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP0513789A3 (en, 2012) | 1994-03-30 |
| JPH04341241A (ja) | 1992-11-27 |
| EP0513789A2 (en) | 1992-11-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20070815 Year of fee payment: 10 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20080815 Year of fee payment: 11 |
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| LAPS | Cancellation because of no payment of annual fees |