JP2643260B2 - Syrup - Google Patents
SyrupInfo
- Publication number
- JP2643260B2 JP2643260B2 JP63069037A JP6903788A JP2643260B2 JP 2643260 B2 JP2643260 B2 JP 2643260B2 JP 63069037 A JP63069037 A JP 63069037A JP 6903788 A JP6903788 A JP 6903788A JP 2643260 B2 JP2643260 B2 JP 2643260B2
- Authority
- JP
- Japan
- Prior art keywords
- syrup
- cimetidine
- acid
- added
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000006188 syrup Substances 0.000 title claims description 20
- 235000020357 syrup Nutrition 0.000 title claims description 20
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 claims description 14
- 229960001380 cimetidine Drugs 0.000 claims description 14
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims description 9
- 229960004949 glycyrrhizic acid Drugs 0.000 claims description 9
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims description 9
- 235000019410 glycyrrhizin Nutrition 0.000 claims description 9
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 9
- 150000003839 salts Chemical class 0.000 claims description 9
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 claims description 8
- 239000001685 glycyrrhizic acid Substances 0.000 claims description 8
- 235000003599 food sweetener Nutrition 0.000 description 9
- 239000003765 sweetening agent Substances 0.000 description 9
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- 239000000796 flavoring agent Substances 0.000 description 6
- 235000019634 flavors Nutrition 0.000 description 6
- 235000019658 bitter taste Nutrition 0.000 description 5
- 239000008213 purified water Substances 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 4
- 229930006000 Sucrose Natural products 0.000 description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 4
- 229940085605 saccharin sodium Drugs 0.000 description 4
- 229960002920 sorbitol Drugs 0.000 description 4
- 239000005720 sucrose Substances 0.000 description 4
- 241000220223 Fragaria Species 0.000 description 3
- 235000016623 Fragaria vesca Nutrition 0.000 description 3
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 3
- 239000004299 sodium benzoate Substances 0.000 description 3
- 235000010234 sodium benzoate Nutrition 0.000 description 3
- 239000000654 additive Substances 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- -1 alkali metal salts Chemical class 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 239000004115 Sodium Silicate Substances 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 244000290333 Vanilla fragrans Species 0.000 description 1
- 235000009499 Vanilla fragrans Nutrition 0.000 description 1
- 235000012036 Vanilla tahitensis Nutrition 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000003699 antiulcer agent Substances 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 235000013736 caramel Nutrition 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- KCIDZIIHRGYJAE-YGFYJFDDSA-L dipotassium;[(2r,3r,4s,5r,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl] phosphate Chemical compound [K+].[K+].OC[C@H]1O[C@H](OP([O-])([O-])=O)[C@H](O)[C@@H](O)[C@H]1O KCIDZIIHRGYJAE-YGFYJFDDSA-L 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 229960001855 mannitol Drugs 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000007968 orange flavor Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229910052911 sodium silicate Inorganic materials 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229960004793 sucrose Drugs 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000001040 synthetic pigment Substances 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 description 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
【発明の詳細な説明】 ［産業上の利用分野］ この発明はシメチジンのシロップ剤、さらに詳しく
は、シメチジンおよびグリチルリチン酸またはその塩を
含有する溶解シロップ剤に関するものであり、医療の分
野で利用される。The present invention relates to a syrup of cimetidine, and more particularly to a dissolved syrup containing cimetidine and glycyrrhizic acid or a salt thereof, and is used in the medical field. You.
［従来技術］ 従来、シロップ剤を製造する際の甘味剤としては、シ
ョ糖、Ｄ−ソルビトール、サッカリンナトリウムなどが
汎用されている。[Prior Art] Conventionally, sucrose, D-sorbitol, saccharin sodium and the like have been widely used as sweeteners for producing syrups.
［発明が解決しようとする問題点］ シメチジンは下記の化学構造を有する抗潰瘍剤であ
り、その優れた薬効のため広く用いられているが、強い
苦味を有するために、これを内服用の液剤とする場合に
は、その苦味を防止することが必要である。[Problems to be Solved by the Invention] Cimetidine is an anti-ulcer agent having the following chemical structure, and is widely used for its excellent medicinal effect. However, since it has strong bitterness, it is used as a liquid preparation for internal use. If so, it is necessary to prevent the bitterness.
そのためにはシロップ剤とすることが最も好ましい
が、従来シロップ剤を製造するために用いられている前
記の甘味剤を添加するだけでは、それらをシロップ剤に
添加し得る最大量を加えても、甘味が持続せず、後にシ
メチジンの苦味が残るためシロップ剤として満足できる
ものではなかった。 For that purpose, it is most preferable to use a syrup, but by simply adding the above-mentioned sweeteners conventionally used for producing a syrup, even if the maximum amount that can be added to the syrup is added, The sweetness did not last, and the bitterness of cimetidine remained, which was not satisfactory as a syrup.
［問題点を解決するための手段］ この発明の発明者らは、上記の問題点を解決するため
に鋭意検討した結果、従来より食品などの甘味剤として
用いられているグリチルリチン酸またはその塩を加えて
溶解シロップ剤を調製すると、シメチジンの苦味を防止
でき、甘味が持続することを見出してこの発明を完成し
た。[Means for Solving the Problems] The inventors of the present invention have conducted intensive studies to solve the above problems, and as a result, have found that glycyrrhizic acid or a salt thereof, which has been conventionally used as a sweetener for foods and the like, has been developed. In addition, when a dissolved syrup was prepared, it was found that the bitterness of cimetidine could be prevented and the sweetness was maintained, and the present invention was completed.
この発明で用いられるグリチルリチン酸の塩として
は、ナトリウム塩、カリウム塩などのアルカリ金属塩、
アンモニウム塩などが挙げられる。The salts of glycyrrhizic acid used in the present invention include sodium salts, alkali metal salts such as potassium salts,
Ammonium salts and the like.
グリチルリチン酸およびその塩はそれぞれ単独で用い
てもよく、また両者を組み合わせて用いてもよく、ある
いは従来の甘味剤と併用してもよい。Glycyrrhizic acid and its salts may be used alone or in combination, or may be used in combination with a conventional sweetener.
溶解シロップ剤中のグリチルリチン酸またはその塩の
添加量は、シメチジンの配合量によって適宜決めること
ができるが、従来の甘味剤を併用する場合、通常0.05〜
１％程度が好ましい。The amount of glycyrrhizic acid or a salt thereof in the dissolving syrup can be determined as appropriate depending on the amount of cimetidine.
About 1% is preferable.
グリチルリチン酸またはその塩と併用される甘味剤と
しては、例えばショ糖、ブドウ糖、果糖、麦芽糖、乳糖
などの糖類、Ｄ−ソルビトール、マンニトール、キシリ
トールなどの糖アルコール類、サッカリンナトリウムな
どが挙げられ、これらの甘味剤は２種以上組み合わせて
用いてもよい。これらの甘味剤の総添加量は、シメチジ
ンの配合量によって適宜決めることができるが、通常20
〜60％程度が好ましい。Examples of the sweetener used in combination with glycyrrhizic acid or a salt thereof include sugars such as sucrose, glucose, fructose, maltose and lactose, sugar alcohols such as D-sorbitol, mannitol and xylitol, and saccharin sodium. Two or more sweeteners may be used in combination. The total amount of these sweeteners can be appropriately determined depending on the amount of cimetidine, but usually 20
About 60% is preferable.
この発明の溶解シロップ剤には、甘味剤のほかに例え
ば酸味剤（例えばクエン酸、酒石酸、リンゴ酸、乳酸な
どの有機酸またはそのアルカリ金属塩など）、香料（例
えばストロベリーフレーバー、オレンジフレーバー、バ
ニラフレーバーなどの天然または合成フレーバーな
ど）、着色剤（黄色５号などの合成色素、カラメルなど
の天然色素など）、防腐剤（例えば安息香酸、安息香酸
ナトリウム、パラベン類など）、増粘剤（メチルセルロ
ースなど）、可溶化剤、安定化剤などシロップ剤に通常
用いられる添加剤を適宜加えてもよい。The dissolved syrup of the present invention includes, in addition to the sweeteners, for example, sour agents (eg, organic acids such as citric acid, tartaric acid, malic acid, and lactic acid or alkali metal salts thereof), and flavors (eg, strawberry flavor, orange flavor, vanilla). Natural or synthetic flavors such as flavors), coloring agents (synthetic pigments such as yellow No. 5, natural pigments such as caramel), preservatives (eg, benzoic acid, sodium benzoate, parabens, etc.), thickeners (methylcellulose) Etc.), additives usually used in syrups such as solubilizers and stabilizers may be appropriately added.
この発明の溶解シロップ剤は、常法により製造するこ
とができるが、その一例を示せば、まず精製水にシメチ
ジンを加え、次いで塩酸を加えてシメチジンを溶解した
のち、グリチルリチン酸およびその塩などからなる甘味
剤ならびにその他の添加剤を適宜加えて撹拌することに
より製造することができる。The dissolving syrup of the present invention can be produced by a conventional method. For example, cimetidine is first added to purified water, then hydrochloric acid is added to dissolve cimetidine, and then glycyrrhizic acid and its salt are used. It can be produced by appropriately adding a sweetener and other additives and stirring.
［効果］ 以下、この発明の効果を試験例により説明する。[Effects] The effects of the present invention will be described below with reference to test examples.
官能試験 ５名のパネル員により、一対比較法の官能試験で、こ
の発明による後記実施例１のシロップ剤と、対照の後記
参考例１のシロップ剤の味を比較した。Sensory Test The taste of the syrup of Example 1 described later and the syrup of Reference Example 1 described later were compared by a sensory test of a paired comparison method by five panel members.
結果 対照のシロップ剤については５名全員が、最初甘みを
感じたもののその甘味は持続せず、すぐに苦味を感じた
のに対して、この発明のシロップ剤については、５名全
員が、甘味を持続して感じ、苦味はほとんど感じなかっ
た。Results For the control syrup, all five felt sweet at first, but the sweetness did not last and immediately felt bitter, whereas all of the five syrups of the present invention showed sweetness. And felt little bitterness.
参考例１ 精製水（40ml）にシメチジン（2.0g）および特級塩酸
（0.638ml）を加えてシメチジンを溶解した後、ショ糖
（30g）、Ｄ−ソルビトール（20g）、サッカリンナトリ
ウム（0.3g）、クエン酸ナトリウム（0.3g）、安息香酸
ナトリウム（0.2g）およびストロベリーフレーバー（0.
1ml）を加えて撹拌し、精製水で全量を100mlにしてシロ
ップ剤を得る。Reference Example 1 Cimetidine (2.0 g) and special grade hydrochloric acid (0.638 ml) were added to purified water (40 ml) to dissolve cimetidine, and then sucrose (30 g), D-sorbitol (20 g), saccharin sodium (0.3 g), citrate Sodium silicate (0.3g), sodium benzoate (0.2g) and strawberry flavor (0.
1 ml), and the mixture is stirred. The total amount is made up to 100 ml with purified water to obtain a syrup.
［実施例］ 以下、この発明を実施例により説明する。EXAMPLES Hereinafter, the present invention will be described with reference to examples.
実施例１ 精製水（40ml）にシメチジン（2.0g）および特級塩酸
（0.638ml）を加えてシメチジンを溶解した後、ショ糖
（30g）、Ｄ−ソルビトール（20g）、サッカリンナトリ
ウム（0.3g）、グリチルリチン酸ジカリウム塩（0.18
g）、クエン酸ナトリウム（0.3g）、安息香酸ナトリウ
ム（0.2g）およびストロベリーフレーバー（0.1ml）を
加えて撹拌し、精製水で含量を100mlにして、溶解シロ
ップ剤を得る。Example 1 Cimetidine (2.0 g) and special grade hydrochloric acid (0.638 ml) were added to purified water (40 ml) to dissolve cimetidine, and then sucrose (30 g), D-sorbitol (20 g), saccharin sodium (0.3 g), and glycyrrhizin Dipotassium acid salt (0.18
g), sodium citrate (0.3 g), sodium benzoate (0.2 g) and strawberry flavor (0.1 ml) are added and stirred, and the content is adjusted to 100 ml with purified water to obtain a dissolved syrup.
Claims (1)
その塩を含有することを特徴とする溶解シロップ剤。1. A dissolved syrup containing cimetidine and glycyrrhizic acid or a salt thereof.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63069037A JP2643260B2 (en) | 1988-03-22 | 1988-03-22 | Syrup |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP63069037A JP2643260B2 (en) | 1988-03-22 | 1988-03-22 | Syrup |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH01242524A JPH01242524A (en) | 1989-09-27 |
| JP2643260B2 true JP2643260B2 (en) | 1997-08-20 |
Family
ID=13390982
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP63069037A Expired - Lifetime JP2643260B2 (en) | 1988-03-22 | 1988-03-22 | Syrup |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2643260B2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2224634T3 (en) | 1998-04-29 | 2005-03-01 | Sumitomo Pharmaceuticals Company, Limited | ORAL FORMULATION THAT INCLUDES BIGUANIDA AND AN ORGANIC ACID. |
| WO1999059588A1 (en) * | 1998-05-21 | 1999-11-25 | Sumitomo Pharmaceuticals Co., Ltd. | Medicinal composition reduced in bitterness |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2409758A1 (en) * | 1977-11-25 | 1979-06-22 | Macandrews & Forbes Co | Sweetener for food and drinks - contains lactose and small quantities of ammonium glycyrrhizic acid, saccharin and a nucleotide |
| ATE23659T1 (en) * | 1983-07-13 | 1986-12-15 | Gen Foods Corp | SWEETENER COMPOSITION AND METHODS OF ALTERING THE SWEETNESS PERCEPTION OF A FOOD. |
| ZA855107B (en) * | 1983-07-13 | 1985-01-14 | ||
| CA1239349A (en) * | 1983-10-10 | 1988-07-19 | Eberhard F. Gottwald | Pharmaceutical composition containing cimetidine |
-
1988
- 1988-03-22 JP JP63069037A patent/JP2643260B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH01242524A (en) | 1989-09-27 |
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