JP2580657B2 - Oral composition - Google Patents

Description

Description: TECHNICAL FIELD The present invention relates to an oral composition having an excellent effect of preventing bad breath.

2. Description of the Related Art Problems to be Solved by the Related Art and the Invention Conventionally, it is known to add a solvent extract of a Labiatae plant such as rosemary to impart a bad breath preventing effect to an oral composition such as a toothpaste. (JP-A-59-5110).
However, the composition of such a plant extract may cause the oral composition to be colored, which may impair the appearance of the composition, and it is difficult to say that the effect of preventing bad breath is sufficient.

On the other hand, it is also known that copper compounds such as copper gluconate and copper citrate have an effect of removing bad breath, and various oral compositions containing a copper compound have been proposed (US Patent No. 3,044).
No. 4,939, No. 3,565,933, No. 3,655,868, No. 4,1
12,066, JP-A-56-169919, JP-A-56-169620, JP-A-61-37720, JP-A-61-143317, and JP-A-62-142109.

However, according to the study of the present inventors, the bad breath removing effect of these copper compounds is easily deactivated at high pH, and in particular, the oral composition is adjusted using a high pH abrasive such as calcium carbonate or aluminum hydroxide. In this case, it was found that the effect of removing bad breath became inferior.

Means and action for solving the problem For this reason, the present inventors, even when using a high pH abrasive such as calcium carbonate and aluminum hydroxide, the bad breath removal effect of the copper compound is not deactivated, As a result of further study on a composition for the oral cavity which exerts an excellent bad breath suppressing action, it has been found that copper gluconate and its alkali metal salts and copper citrate and its alkali metal salts are selected from one or more copper compounds. On the other hand, mixing a polybasic acid selected from tartaric acid, citric acid, orthophosphoric acid, metaphosphoric acid and polyphosphoric acid and an alkali metal salt thereof, particularly in this case, adjusting the pH of the oral composition to a range of 4 to 8 By doing so, it was found that both of these components act synergistically to exert a remarkable effect of preventing bad breath, and the present invention has been accomplished.

 Hereinafter, the present invention will be described in more detail.

The oral composition according to the present invention is, as described above, one or two or more copper compounds selected from copper gluconate and alkali metal salts thereof and copper citrate and alkali metal salts, tartaric acid, citric acid, It is obtained by using a polybasic acid selected from orthophosphoric acid, metaphosphoric acid and polyphosphoric acid and one or more kinds of alkali metal salts thereof in combination.

Here, the compounding amount of the copper compound is 0.0000 of the entire composition.
It is preferably set to 1 to 2% (weight%, the same applies hereinafter), particularly 0.001 to 0.5%.

As the polybasic acid and its alkali metal salt, those which are water-soluble and have a buffering capacity are preferably used. Specifically, tartaric acid, citric acid orthophosphoric acid, metaphosphoric acid, polyphosphoric acid and its sodium salts, potassium And the like. The alkali metal salt may be a neutral salt such as sodium tartrate or sodium citrate, or an acidic salt such as potassium dihydrogen phosphate or sodium monohydrogen phosphate.

In addition, the compounding amount of the polyvalent metal salt or the alkali metal salt thereof,
The content is preferably 0.001 to 5%, particularly 0.003 to 2% of the whole composition.

The oral composition according to the present invention can be prepared into pastes, liquids and other dosage forms depending on various applications, such as toothpaste, toothpaste, dentifrice such as liquid toothpaste, mouthwash, etc. As other components of the oral composition, appropriate components usually used depending on the purpose and the like can be blended. For example, in the case of toothpaste, an abrasive, a binder, a humectant, a surfactant, a sweetener, a fragrance, a preservative, various active ingredients, and the like can be blended.

In this case, according to the present invention, by using a polybasic acid or an alkali metal salt thereof in combination with the copper compound, the degree of freedom of component selection at the time of adjusting the oral composition is increased, for example, when adjusting toothpaste PH of 8.5 wt% water slurry is 8.5
The above high pH abrasives (calcium carbonate, aluminum hydroxide, etc.) can also be used effectively.

In adjusting the oral composition, the pH of the composition is adjusted to 4 to 8, particularly 5 to 7 in order to more effectively exert the combined effect of the copper compound and the polybasic acid or the alkali metal salt thereof. Adjustment is preferred. This pH adjustment can be effectively performed by selecting the type and amount of the polybasic acid or its alkali metal salt.

Effect of the Invention The oral composition of the present invention has an excellent breath odor removing effect, and uses a copper compound as an effective deodorant component, so that the composition is not colored, and calcium carbonate and hydroxide Components that cause pH fluctuation of a composition such as aluminum can be blended without any trouble, and the degree of freedom in selecting components when adjusting the composition is great.

Next, the effects of the present invention will be specifically described with reference to experimental examples.

〔Example〕

A toothpaste having the composition shown in Table 1 was prepared by a conventional method, and its appearance, pH, and deodorizing power were examined. The results are shown in Table 1. The deodorizing power was measured by the following method.

Deodorizing power measurement method 1 g of dentifrice was placed in a test tube having a content of 15 ml, and the pH was adjusted to 7.5 by adding a 0.1 M phosphate buffer solution. A 10% by volume aqueous ethanol solution containing 1 μg / ml of methyl mercaptan was added to this.
5 ml (0.5 μg of methyl mercaptan) was added and immediately stoppered with a rubber stopper and stirred vigorously for 1 minute. Then, after standing still at 37 ° C for 6 minutes, 5m with a syringe for gas chromatography
l of air was injected into the test tube by piercing a rubber stopper. 30
After vigorous stirring for 5 seconds, 5 ml of gas was sampled from the headspace with the same gas syringe, immediately injected into the gas chromatograph, the integral count of methyl mercaptan was measured, and the deodorizing rate was determined from the following equation. As a gas chromatograph, 163 manufactured by Hitachi, Ltd. was used.

C: integral count of control (water) S: integral count of sample From the results in Table 1, it can be seen that toothpaste containing a plant extract as a deodorant active ingredient (Comparative product 1) is brown and impaired in appearance, is inferior in deodorant effect, and is polybasic acid and its alkali metal. Copper salt-containing toothpastes containing no salt and having a high composition pH (comparative products 2, 3) have good appearance but low deodorizing effect. On the other hand, a toothpaste containing a copper salt containing a polybasic acid or an alkali metal salt thereof (Products 1 to 3 of the present invention)
Was confirmed to have a good appearance and show an excellent deodorizing effect.

Hereinafter, the present invention will be described specifically with reference to Examples.
The present invention is not limited to the following examples.

 The percentages shown below all represent weight percentages.

[Example 1] Toothpaste Copper gluconate 0.05% Citric anhydride 0.03 Sodium citrate (dihydrate) 0.1 Calcium carbonate 45.0 Propylene glycol 3.0 Sorbit solution (60%) 30.0 Sodium carboxymethyl cellulose 0.8 Carrageenan 0.3 Saccharin sodium 0.1 Sodium lauryl sulfate 1.5 Sodium benzoate 0.2 Methyl paraoxybenzoate 0.02 Fragrance 1.0 Purified water Balance 100.0% pH 6.9 [Example 2] Toothpaste Copper citrate 0.1% Potassium dihydrogen phosphate 0.08 Sodium monohydrogen phosphate (12 hydrate) 0.007 Hydroxide Aluminum 45.0 Propylene glycol 2.5 Sorbit solution (60%) 15.0 Glycerin 10.0 Sodium carboxymethylcellulose 0.5 Sodium alginate 0.4 Dipotassium glycyrrhizinate 0.05 Sucrose laurate ester 1.0 Methyl paraoxybenzoate 0.04 Paraoxyl Ikikosan butyl 0.01 Perfume 1.0 Purified water balance Total 100.0% pH 6.2 Example 3 Toothpaste gluconate 0.08% tartaric acid 0.004 sodium tartrate (dihydrate) 0.11 Aluminum hydroxide 45.0 Propylene glycol 2.0 Sorbitol solution (60%) 25.0 Sodium carboxymethyl cellulose 1.2 Sodium saccharin 0.1 Sodium lauryl sulfate 1.0 Sodium N-lauroyl sarcosine 0.3 Sodium benzoate 0.1 Butyl paraoxybenzoate 0.01 Fragrance 1.0 Dextranase 5000u / g Purified water Balance 100.0% pH 5.3 [Example 4] Toothpaste Copper acid 0.04% Pyrophosphate 0.09 Sodium pyrophosphate 0.22 Magnesium carbonate 45.0 Propylene glycol 3.0 Sorbit solution (60%) 12.0 Glycerin 8.0 Sodium carboxymethylcellulose 0.5 Xanthan gum 0.5 Dipotassium glycyrrhizinate 0.05 Lauryl Sodium 1.2 Perfume 1.0 Tranexamic acid 0.1 Purified water balance Total 100.0% pH 6.1

Claims (2)

(57) [Claims] 1. One or more copper compounds selected from copper gluconate and its alkali metal salts and copper citrate and its alkali metal salts, and tartaric acid, citric acid, orthophosphoric acid, metaphosphoric acid and polyphosphoric acid An oral composition comprising a combination of one or more polybasic acids and alkali metal salts thereof selected from the group consisting of: 2. The oral composition according to claim 1, wherein the composition has a pH of 4 to 8.