JP2568099B2 - Disinfectant composition - Google Patents

Description

DETAILED DESCRIPTION OF THE INVENTION (1) Object of the Invention Industrial Field of the Invention The present invention relates to a fungicide composition, and more particularly to an agricultural / horticultural fungicide composition having an improved disease control effect on plants.

BACKGROUND ART A bactericide containing tetrachloroisophthalonitrile (hereinafter referred to as TPN) as an active ingredient has been put to practical use as a chemical with a strong protective action, and especially for the purpose of controlling disease of fruits and vegetables as a bactericide for agriculture and horticulture. It is widely used by being sprayed on plants or mixed with soil.

On the other hand, the general formula [I] [In the formula, Z is 2-oxo-1,3-oxazolidine-3-
Represents 1- (methoxycarbonyl) ethyl or 2-oxo-thiolan-3-yl. ] The compound (hereinafter referred to as phenylamide compound) represented by
It has an excellent control effect against downy mildew and blight that cause great damage to vegetables, and because it penetrates into the plant body, it not only has a preventive effect, but also acts on pathogenic bacteria that have invaded into the tissues of the plant and Is known to be able to prevent the spread of.

To broaden the sterilization spectrum and enable simultaneous control
A mixed bactericide of TPN and other bactericidal active compounds, for example, a mixed bactericide of methyl 3- (butylcarbamoyl) -3H-benzimidazol-2-ylcarbamate (general name benomyl) is used. Further, in order to broaden the sterilization spectrum of phenylamide compounds and as a countermeasure against resistant bacteria, various mixed bactericides such as basic copper chloride and mixed bactericide with manzeb are used.

2-methoxy-N which is a phenylamide compound with TPN
-(2-oxo-1,3-oxazolidin-3-yl) aceto-2 ', 6'-xylidine (generic name oxadixyl)
The mixed use with, Trans.Br.mycol.Soc. 85, 299
~ 306 (1985). However, the above document does not disclose that TPN and oxadixyl have a sufficient synergistic effect. Moreover, the TPN used is used as a wettable powder, and the mixing ratio of oxadixyl and TPN is only 1: 3.

Problems to be Solved by the Invention Agricultural chemicals currently on the market have excellent control effects at the current doses, and have little adverse effect on the environment, but to further enhance safety to the environment. Therefore, it is desired to reduce the amount of drug to be dropped by efficiently using the active ingredient. Regarding TPN agents as well, research is underway to further reduce the amount of drug applied to crops in order to further enhance the safety to the environment.However, the control efficacy of previously known compositions decreases when the amount of drug applied is decreased. There was a problem to do.

Generally, when two or more kinds of bactericidal active ingredients are mixed and used, the bactericidal effect is classified into a mere additive effect, an antagonistic effect or a synergistic effect. And when it shows a synergistic effect, it leads to the reduction of the amount of drug dropped,
It can be expected to provide a more safe and economical drug.

In particular, there has been a problem that a bactericidal composition having the excellent characteristics of each of the above TPN and oxadixyl and having a synergistic effect has not been known so far in spite of strong demand.

(2) Structure of the Invention Means for Solving Problems The present inventors have conducted earnest studies in such an actual situation, and as a result, 1: 3 with a phenylamide compound and TPN as active ingredients.
To a 1:13 ratio, and the particle size distribution of the solid component is a flowable formulation having a particle size distribution at a 50% volume cumulative point (hereinafter referred to as VMD) of 0.8 to 2.5 μm. It has been found that the compound has excellent characteristics of each of TPN and a phenylamide compound, and surprisingly has an extremely strong synergistic effect, and thus completed the present invention.

There is no particular limitation on the method for producing the disinfectant composition of the present invention. It can be produced by a general blending using a crusher that has been used conventionally.

The crusher can be easily manufactured by using an efficient crusher.

Examples of these crushers include a ball mill, an impact crusher, a jet crusher, and a wet crusher.

 VMD is a coulter counter Model TA-11 (Stock Association
Company Nikkaki) was measured. VMD is 0.8μm or more
2.5 μm is preferable, but 0.8 μm to 1.8 μm is particularly preferable.
New

The content of TPN and phenylamide compound in the composition of the present invention is not particularly limited, but is 1% to 98%.
It is desirable to be used in a degree. The content ratio of TPN and phenylamide compound is preferably 1: 3 to 1:13, but 1: 4 to
1:11 is particularly preferred.

The application amount is not necessarily limited, but usually 1 to 500 g / 10a as an active ingredient compound (AI) when applied to a field where a crop grows, and 0.1 to 5 kg when applied to soil. (Al) / 10a is suitable.

Of course, this is one guideline, and is appropriately adjusted as necessary in consideration of factors such as the type of crop, the type of disease, the degree of strain, the season, the weather, and the dosage form of the drug.

Next, formulation examples of the composition of the present invention will be described.
It goes without saying that the present invention is not limited to this.

Example 1 Metalaxyl ((±) -methyl N- (2-methoxyace
tyl) -N- (2,6-xylyl) -DL-alaniate) 25 parts Nonipol 100 (Sanyo Kasei Co., Ltd.) 1 part Demol N (Kao Co., Ltd.) 2 parts 72 parts water Wet crusher Eiger Grind using a motor mill (Eiger Japan Co., Ltd.). The crushing time was adjusted to prepare a sample having a VMD of 1.5 μm.

Example 2 Oxadixyl (2-methoxy-N- (2-oxo-1,
3-oxazolidin-3-yl) aceto-2 ', 6'-xylidide) 25 parts Nonipol 100 (Sanyo Kasei Co., Ltd.) 1 part Demol N (Kao Co., Ltd.) 2 parts Water 72 parts were mixed, and Example 1 A sample with a VMD of 1.5 μm was prepared in the same manner as in.

Examples 3 to 6 TPN (tetrachloroisophthalonitrile) 50 parts Nonipol 100 1.5 parts Demol N 3 parts Water 45.5 parts were mixed, and the pulverization time of the Eiger motor mill was adjusted to obtain various flowable agents with different VMD. Samples were prepared.

Example 3 VMD 0.5 μm Example 4 VMD 1.0 μm Example 5 VMD 1.5 μm Example 6 VMD 5 μm Example 7 Oxadixyl 6.4 parts TPN 32.0 parts Nonipol 100 1.5 parts Demol N 3 parts Water 57.1 parts are mixed to form an Eiger motor. The milling time of the mill was adjusted to prepare a sample of VMD 1.0 μm flowable agent.

(3) Effects of the Invention The composition of the present invention is effective for controlling diseases of a wide range of agricultural and horticultural crops, and the main ones are as follows.

Paddy rice: Rice blast, sesame leaf blight, leaf blight, scab seedling disease, seedling blight, etc. Wheat: Red rust, Yellow rust, Naked smut, Leaf blight, Spot disease, Brown snow rot, Udon Diseases, etc. Potato: Late blight, summer blight, black blight, etc. Beans Soybeans: downy mildew, leaf spot, brown spot, sclerotial disease, rust, purple spot, etc. Red beans: brown spot, rust, soot spot disease , Powdery mildew, etc. Peanut: brown spot, black spot, sclerotium, etc. Tobacco: red scab, epidemic, sclerotium, hip fracture, dance, white scab, powdery mildew etc. Beat: downy mildew Brown spot disease, seedling blight, etc. Vegetable tomato: Gray mold, leaf mold, plague, sclerotial disease, ring spot disease, rust mold, wilt disease, seed blight etc. Eggplant: Gray mold, half body wilt Disease, brown rot, black spot,
Powdery mildew, scab, etc. Cucurbits: downy mildew, gray blight, gray mold, sclerotium disease, scab, anthracnose, vine blight, vine wilt, powdery mildew, seedling blight, etc. Chinese cabbage: downy mildew, white spot, sclerotium, root rot, etc. Onion: white blight, downy mildew, gray rot, anthracnose, etc. lettuce: downy mildew, gray mold, brown spot, fungus Nuclear disease, etc. Strawberry: Gray mold, powdery mildew, ring spot disease, etc. Appreciation plant chrysanthemum: White rust, powdery mildew, etc. Cyclamen: Gray mold, etc. Rose: Black scab, powdery mildew Citrus: Blue mold , Gray mold, Black spot, Scab, etc. Apple: Red scab, Spotted leaf spot, Black scab, Monilia disease, Powdery mildew, etc. Pear: Red scab, Black spot, Black scab, etc. Peach: Ash sterility, Black star Disease, phomopress rot, leaf rot, etc. Grape: downy mildew, gray mold, brown spot, black rot, late rot, rust, pestalothia vine Disease, Fusarium wilt, powdery mildew, etc. Further, since the composition of the present invention is a flowable pharmaceutical composition, the following can be considered.

Since it is already dispersed in the liquid, aggregation in diluting water is unlikely to occur and the optimized particle size can be maintained as it is.

Since it is not necessary to add another solid substance as the agent diluent, the decomposition action by the solid substance can be avoided.

By these, the active ingredient can act remarkably and efficiently, and the control effect is improved. When it is actually used, since it has excellent dispersibility in water, it is easily mixed with water and the spray solution can be easily prepared. Since the suspension is also excellent, the drug solution after preparation can maintain a uniform suspension state for a long time, so it can be sprayed at a predetermined concentration from the start to the end of spraying.
The clogging at the time of spraying does not become a problem. After spraying the wettable powder, stains (traces of spray liquid) remain on the fruits and leaves, but since the composition of the present invention does not contain the mineral substances that cause this stain, a crop with very little stain can be obtained. . Furthermore, since it is not a powder, it does not become dusty and can be used more safely.

Hereinafter, in order to specifically describe the effects of the composition of the present invention,
A representative test example is shown.

However, it goes without saying that these are merely examples and the application examples of the present invention are not limited to these.

Test example 1 Spray solution of each agent at the specified concentration (concentration of active ingredient 20,10,5,2,1,0.
5 ppm) was prepared and the tomato (variety: red cherry) in the fifth true leaf stage was sprayed with 200 / 10a of the chemical solution. After spray-drying chemicals (after about 2 hours) Tomato blight (Phytophthora infesta)
ns) zoospore suspension.

Then, keep it in a humid chamber at 21 ° C for 2 days, and then put it in a greenhouse for 2 days.
Left for days.

Five days after the inoculation, the lesion area of the third, fourth and fifth true leaves was investigated and the control value was determined. Then, EC ₉₀ was calculated.

Test Example 2 Dispersion liquid of specified concentration of each agent (active ingredient concentration 20,10,5,2,1,0.
5ppm) cucumber in the second true leaf stage (variety: Tokiwa Hikari 3)
No. P type) was sprayed with an amount equivalent to 200 / 10a of the drug solution. After spray-drying chemicals (after about 2 hours) Cucumber bean and disease (Pseudoperono
sporacubensis).

Then, keep it in a humid chamber at 21 ° C for 2 days, and then keep it in the humid chamber for 2 days.
Left for days.

Five days after the inoculation, the lesion area of the first and second true leaves was investigated,
Control value Then, EC ₉₀ was calculated.

Test Example 3 In the same manner as in Test Example 1, tomatoes were sprayed with the drug solution. Twenty-four hours after spraying, 40 mm / hr of rain was applied for one hour using an artificial rainfall device. Further 3 hours after the tomato late blight since inoculated with zoospore suspension of the fungus for each drug a similar manner to Test Example 1 EC ₉₀
I asked.

Next, the test results are shown in the table. The results of Test Example 1 are shown in Table-1.
The results of Test Example 2 are shown in Table-7 and Table-1, Table-8 to Table-13.
The results of Test Example 3 are shown in Table. However, metalaxyl in the table is methyl N- (2-methoxyacetyl)-
N- (2,6-xylyl) alaniate, particle size is VMD
, FL represents a flowable formulation, WP represents a wettable powder, and SF is an index representing the synergistic effect calculated by the following formula. When SF is larger than 1, it is shown that there is a synergistic effect.

SF = EC ₉₀ (theoretical value) / EC ₉₀ (measured value) [In the formula, X and Y respectively represent the content ratios of the active ingredients a and b in the composition. ] From the above test results, it is shown that the composition of the present invention has an excellent bactericidal effect and a sufficient synergistic effect.

 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Kazuhiro Kojima 2-24-25 Tamagawa, Ota-ku, Tokyo SDS Biotech Co., Ltd. Tokyo Research Laboratory Examiner Michie Hirayama (56) References Sho 62-19501 (JP, A) JP-A-59-51203 (JP, A)

Claims (1)

(57) [Claims] 1. A general formula [I] [In the formula, Z is 2-oxo-1,3-oxazolidine-3-
Represents 1- (methoxycarbonyl) ethyl or 2-oxo-thiolan-3-yl. ] The compound represented by and tetrachloroisophthalonitrile are contained as an active ingredient in a ratio of 1: 3 to 1:13, and the particle size distribution of the solid component is 0.8 μm to 2.5 at a particle size with a volume cumulative 50%. μm
A bactericidal composition which is a flowable formulation between.