JP2557111B2 - Method for producing high-concentration magnesium solution, magnesium solution obtained thereby and use thereof - Google Patents
Method for producing high-concentration magnesium solution, magnesium solution obtained thereby and use thereofInfo
- Publication number
- JP2557111B2 JP2557111B2 JP1304889A JP30488989A JP2557111B2 JP 2557111 B2 JP2557111 B2 JP 2557111B2 JP 1304889 A JP1304889 A JP 1304889A JP 30488989 A JP30488989 A JP 30488989A JP 2557111 B2 JP2557111 B2 JP 2557111B2
- Authority
- JP
- Japan
- Prior art keywords
- magnesium
- magnesium solution
- concentration
- solution obtained
- solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Jellies, Jams, And Syrups (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Description
【発明の詳細な説明】 （産業上の利用分野） 本発明は、難溶性のマグネシウムまたはマグネシウム
化合物を高濃度で含有することができる均質な醗酵乳酸
溶液、ならびにその用途に関する。TECHNICAL FIELD The present invention relates to a homogeneous fermented lactic acid solution which can contain a sparingly soluble magnesium or magnesium compound in a high concentration, and its use.
（従来の技術及びその問題点） マグネシウムは下記のような特徴を有するので、緩下
剤やその他の医薬品としても、又、栄養補給にも昔から
使用されてきた。(Prior art and its problems) Since magnesium has the following characteristics, it has been used for a long time as a laxative, other medicinal product, and nutritional supplement.
繊維と同様に保水効果がある。 It has a water retention effect similar to fiber.
大腸の水分吸収を抑えて便を軟かくしスムーズに排
泄する。It suppresses water absorption in the large intestine, softens stool and excretes smoothly.
飲みすぎても腹痛がおこらず副作用なし。 If you drink too much, there will be no abdominal pain and no side effects.
腔中の酸を中和し、歯を丈夫にし舌や口中のあれを
治す。It neutralizes the acid in the cavity, strengthens the teeth and heals the tongue and mouth.
胃酸を適正に調和し、胃壁の小さなタダレを治す。 It properly balances the acidity of the stomach and cures small lumps on the stomach wall.
小腸内壁の炎症を治し、栄養の吸収を良くする。 It cures inflammation of the lining of the small intestine and improves nutrient absorption.
腸の働きを活発にし、腸壁にこびりついた宿便をと
る。Activate the intestines and take the bowel movements that stick to the intestinal wall.
発ガン物質である一酸化炭素を消す。 Extinguishes carbon monoxide, a carcinogen.
栄養素としてのマグネシウムの働き。 The function of magnesium as a nutrient.
以上の如く、人体に於て上記のような特性を備え、こ
とに便秘薬としては副作用も痛みも伴なわない最も理想
的な素材であるにもかかわらず、広く大衆に使用されて
いないのは大量に飲まなければ効果が得られないうえ、
非常に現状の製品では飲みにくいためであるということ
がわかった。As described above, it has the above-mentioned properties in the human body, and is the most ideal material as a constipation drug with neither side effects nor pain, but it is not widely used by the general public. If you don't drink too much, you won't get the effect,
It turns out that it is difficult to drink with the current products.
そこで、マグネシウムまたはマグネシウム化合物を高
濃度で含有する液体とし、且つ、飲み易くするにはどう
したらようかという店に着目して研究を重ねてきたが、
その研究を進める過程で最も大きな障害となったのは大
量に飲まなければならないのに（便秘の効果を得るため
には約2,000mgを１回に飲む必要がある）マグネシウム
またはマグネシウム化合物の溶解度の低さという店であ
る。Therefore, we have been conducting research by focusing on a store that makes it a liquid containing magnesium or a magnesium compound at a high concentration, and how to make it easy to drink.
The biggest obstacle in the course of the study was the need to drink large amounts (about 2,000 mg per dose to get the effect of constipation) of magnesium or magnesium compound solubility. It's a low store.
従来下記に示す如く、クエン酸、リンゴ酸、酢酸、塩
酸、乳酸によりマグネシウムまたはマグネシウム化合物
の溶解を試みたがマグネシウムまたはマグネシウム化合
物が高濃度で含有し、かつ、飲み易い味の液体及び加工
食品は得られなかった。Conventionally, as shown below, citric acid, malic acid, acetic acid, hydrochloric acid, tried to dissolve magnesium or magnesium compound with lactic acid, but magnesium or magnesium compound is contained at a high concentration, and the liquid and processed food with easy taste are I couldn't get it.
又従来、水酸化マグネシウムを含有した乳液状の制酸
緩下剤は発売され公知である（製造元：株式会社 三保
製薬研究所 商品名スイマグ）。 Further, conventionally, an emulsion-type antacid laxative containing magnesium hydroxide has been released and is publicly known (manufacturer: Miho Pharmaceutical Laboratory Co., Ltd., trade name Suimag).
しかし乍ら、2,000mg飲まないと排便効果が得られ
ず、量が多いので錠剤でも水溶液でも飲み難く、酸に可
溶でも酸が強度であるため非常に飲用しにくい。However, the defecation effect cannot be obtained unless 2,000 mg is taken, and it is difficult to take tablets or an aqueous solution because of the large amount, and it is very difficult to drink because it is soluble in acid and the acid is strong.
（発明の目的） 本発明は難溶性で、かつ、まずいマグネシウムまたは
マグネシウム化合物を、極めて飲み易い状態又は食べや
すい状態で提供することを目的とする。(Object of the Invention) An object of the present invention is to provide a poorly soluble and poor magnesium or magnesium compound in an extremely easy-to-drink state or an easy-to-eat state.
（問題点を解決するための手段） 本発明は上記目的を達成するためになされたもので、
マグネシウム化合物を水溶液とし、醗酸法により製造し
た乳酸溶液を加えた後、40℃以下の温度で溶解すること
により、高濃度のマグネシウムまたはマグネシウム化合
物を含有するマグネシウム液剤または該マグネシウム液
剤を添加した飲料及び加工食品を得ることを見い出した
ものである。(Means for Solving Problems) The present invention has been made to achieve the above object,
Magnesium compound as an aqueous solution, after adding a lactic acid solution produced by the lactic acid method, by dissolving at a temperature of 40 ℃ or less, magnesium solution containing a high concentration of magnesium or magnesium compound or a beverage containing the magnesium solution And to obtain processed foods.
（発明の好適態様） 醗酵法により製造した乳酸 醗酵乳酸とはC3H6O3で表わされるもので、デンプンな
どの糖類を原料として乳酸菌をはたらかせることによっ
て醗酵させたもので、式 で表わされる光学活性型Ｌ（＋）乳酸が好適に使用され
る。The lactic acid fermentation lactic acid produced by fermentation (the preferred embodiment of the invention) those represented by C 3 H 6 O 3, which was fermented by exert a lactic acid bacteria of sugars such as starch as a raw material, wherein The optically active L (+) lactic acid represented by is preferably used.
醗酵法により製造した乳酸は、未反応のでんぷん、ぶ
どう糖等を含有するため、刺激のないまろやかな味を有
しており、食品本来の味を損ねることがない。Lactic acid produced by the fermentation method contains unreacted starch, glucose, etc., and thus has a mild taste without irritation and does not impair the original taste of food.
本発明に用いるマグネシウムまたはマグネシウム化合
物は天然に存在するもの（例えば、海水中のニガリ等）
及び工業用に合成されたもの何れでもよい。The magnesium or magnesium compound used in the present invention is a naturally occurring one (for example, bittern in seawater).
Also, any of those synthesized for industrial use may be used.
ニガリについては鉄、カルシウム、硫黄分を微量含む
が溶解可能である。Bittern contains trace amounts of iron, calcium and sulfur, but can be dissolved.
（実施例） 実施例1. マグネシウム溶液製法の実施例 水85ccに対してマグネシウムの粉未（平均粒径200メ
ッシュ）2.0grを加え撹拌しマグネシウムの水溶液を得
た。(Example) Example 1. Example of magnesium solution manufacturing method To 85 cc of water, 2.0 g of magnesium powder (average particle size: 200 mesh) was added and stirred to obtain an aqueous solution of magnesium.
次に90％濃度の醗酵法により製造した乳酸の水溶液15
ccを前記マグネシウムの水溶液と混合した。これを30℃
の撹拌槽を有する恒温槽で10分間撹拌を行った後、常温
で静置した所、10週間後に於てもマグネシウムの沈澱は
全く認められず、しかも厚味のあるたおやかな酸味を有
する水溶性緩下剤が得られた。Next, a 90% aqueous solution of lactic acid produced by fermentation 15
cc was mixed with the aqueous magnesium solution. 30 ° C
After stirring for 10 minutes in a constant temperature bath with a stirring tank, the mixture was allowed to stand at room temperature, no precipitation of magnesium was observed even after 10 weeks, and it was water-soluble with a thick and mild acidity. A laxative was obtained.
実施例2. 実施例１によって得られたマグネシウム溶液100ccに
水飴200gr、グラニュー糖200grを混合し、75±５℃の温
度でブリックスが75乃至76になるまで加熱した後、加熱
温度を60℃に下げ、そのまゝ静置した（原料１）。Example 2 100 ml of the magnesium solution obtained in Example 1 was mixed with 200 ml of starch syrup and 200 gr of granulated sugar, and the mixture was heated at a temperature of 75 ± 5 ° C. until the brix became 75 to 76, and then the heating temperature was raised to 60 ° C. Lowered and let it stand still (raw material 1).
別の容器に寒天15gr、水500ccを混ぜ、90℃で加熱を
行い、その後、寒天の泡を除いてオリゴ糖500grを加
え、75±５℃でブリックスが75〜76になる迄、加熱を続
けた（原料２）。Mix agar (15gr) and water (500cc) in another container, heat at 90 ℃, remove the agar foam, add oligosaccharide (500gr), and continue heating at 75 ± 5 ℃ until the brix becomes 75-76. (Raw material 2).
次に原料１と原料２をよく混ぜ合わせ約65℃の温度で
型に流し込み、ゼリー状に固化したら取り出し規定の寸
法にカットし、約40℃の乾燥機で最終ブリックス80にな
る迄、約20時間乾燥した。Next, mix raw material 1 and raw material 2 well, pour into a mold at a temperature of about 65 ° C, take out after solidifying into a jelly form, cut into specified dimensions, and dry at about 40 ° C until the final brix 80 reaches about 20. Dried for hours.
こうして得られたゼリーは1.5cm×3cm×1.5cmの寸法
で重量は約3grである。その一片につき約100mgのマグネ
シウムを含有する高濃度のマグネシウム入り加工食品が
得られた。The jelly thus obtained measures 1.5 cm × 3 cm × 1.5 cm and weighs about 3 gr. A processed food with a high concentration of magnesium containing about 100 mg of magnesium per piece was obtained.
Claims (4)
あらかじめ水溶液としたものに、醗酵法により製造した
乳酸溶液を加えた後、40℃以下の温度で溶解することを
特徴とする高濃度のマグネシウム溶液の製造方法。1. A method for producing a high-concentration magnesium solution, which comprises adding a lactic acid solution produced by a fermentation method to a solution of magnesium or a magnesium compound in advance and then dissolving it at a temperature of 40 ° C. or lower. .
度のマグネシウム溶液。2. A high-concentration magnesium solution obtained by the method according to claim 1.
度マグネシウム溶液からなる液状緩下剤。3. A liquid laxative comprising a high-concentration magnesium solution obtained by the method of claim 1.
度のマグネシウム溶液を添加した加工食品。4. A processed food to which a high-concentration magnesium solution obtained by the method according to claim 1 is added.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1304889A JP2557111B2 (en) | 1989-11-27 | 1989-11-27 | Method for producing high-concentration magnesium solution, magnesium solution obtained thereby and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1304889A JP2557111B2 (en) | 1989-11-27 | 1989-11-27 | Method for producing high-concentration magnesium solution, magnesium solution obtained thereby and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03168067A JPH03168067A (en) | 1991-07-19 |
| JP2557111B2 true JP2557111B2 (en) | 1996-11-27 |
Family
ID=17938503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1304889A Expired - Lifetime JP2557111B2 (en) | 1989-11-27 | 1989-11-27 | Method for producing high-concentration magnesium solution, magnesium solution obtained thereby and use thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2557111B2 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8999313B2 (en) | 2012-09-11 | 2015-04-07 | Norgine Bv | Compositions |
| US9592252B2 (en) | 2011-03-11 | 2017-03-14 | Norgine Bv | Colonoscopy—preparation |
| US10624879B2 (en) | 2014-03-19 | 2020-04-21 | Ferring International Center S.A. | Liquid pharmaceutical composition |
| US11612592B2 (en) | 2015-08-17 | 2023-03-28 | Ferring B.V. | Liquid formulations containing picosulfate and magnesium citrate |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07143863A (en) * | 1993-11-24 | 1995-06-06 | Maguoole Sci Kk | Method for producing magnesium-reinforced food |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6055496A (en) * | 1983-09-07 | 1985-03-30 | 株式会社日立製作所 | Job direction/operation recorder |
| GB8718969D0 (en) * | 1987-08-11 | 1987-09-16 | Pentlands Scotch Whisky Resear | Foodstuffs compositions |
-
1989
- 1989-11-27 JP JP1304889A patent/JP2557111B2/en not_active Expired - Lifetime
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9592252B2 (en) | 2011-03-11 | 2017-03-14 | Norgine Bv | Colonoscopy—preparation |
| US11529368B2 (en) | 2011-03-11 | 2022-12-20 | Norgine Bv | Colonoscopy—preparation |
| US8999313B2 (en) | 2012-09-11 | 2015-04-07 | Norgine Bv | Compositions |
| US9326969B2 (en) | 2012-09-11 | 2016-05-03 | Norgine Bv | Compositions |
| US9707297B2 (en) | 2012-09-11 | 2017-07-18 | Norgine Bv | Compositions |
| US10016504B2 (en) | 2012-09-11 | 2018-07-10 | Norgine Bv | Compositions |
| US10624879B2 (en) | 2014-03-19 | 2020-04-21 | Ferring International Center S.A. | Liquid pharmaceutical composition |
| US11191753B2 (en) | 2014-03-19 | 2021-12-07 | Ferring International Center Sa. | Liquid pharmaceutical composition |
| US11612592B2 (en) | 2015-08-17 | 2023-03-28 | Ferring B.V. | Liquid formulations containing picosulfate and magnesium citrate |
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03168067A (en) | 1991-07-19 |
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