JPH03168067A - Production of magnesium solution containing magnesium and magnesium compound at high concentration and medicine and processed food using the same magnesium solution - Google Patents
Production of magnesium solution containing magnesium and magnesium compound at high concentration and medicine and processed food using the same magnesium solutionInfo
- Publication number
- JPH03168067A JPH03168067A JP1304889A JP30488989A JPH03168067A JP H03168067 A JPH03168067 A JP H03168067A JP 1304889 A JP1304889 A JP 1304889A JP 30488989 A JP30488989 A JP 30488989A JP H03168067 A JPH03168067 A JP H03168067A
- Authority
- JP
- Japan
- Prior art keywords
- magnesium
- lactic acid
- solution
- high concentration
- processed food
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title claims abstract description 39
- 239000011777 magnesium Substances 0.000 title claims abstract description 38
- 229910052749 magnesium Inorganic materials 0.000 title claims abstract description 38
- 235000021067 refined food Nutrition 0.000 title claims abstract description 8
- 150000002681 magnesium compounds Chemical class 0.000 title claims description 14
- 239000003814 drug Substances 0.000 title abstract description 4
- 238000004519 manufacturing process Methods 0.000 title description 3
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims abstract description 34
- 239000004310 lactic acid Substances 0.000 claims abstract description 17
- 235000014655 lactic acid Nutrition 0.000 claims abstract description 17
- 239000008141 laxative Substances 0.000 claims abstract description 7
- 230000002475 laxative effect Effects 0.000 claims abstract description 7
- 239000000243 solution Substances 0.000 claims description 8
- 239000007864 aqueous solution Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 3
- 229920002472 Starch Polymers 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 abstract description 3
- 235000019698 starch Nutrition 0.000 abstract description 3
- 239000008107 starch Substances 0.000 abstract description 3
- 241000894006 Bacteria Species 0.000 abstract description 2
- 235000013305 food Nutrition 0.000 abstract description 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 230000037406 food intake Effects 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 238000010306 acid treatment Methods 0.000 description 5
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000002994 raw material Substances 0.000 description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 2
- 241001131796 Botaurus stellaris Species 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- JVTAAEKCZFNVCJ-REOHCLBHSA-N L-lactic acid Chemical compound C[C@H](O)C(O)=O JVTAAEKCZFNVCJ-REOHCLBHSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000001630 malic acid Substances 0.000 description 2
- 235000011090 malic acid Nutrition 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 231100000957 no side effect Toxicity 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 235000019614 sour taste Nutrition 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 208000024780 Urticaria Diseases 0.000 description 1
- 230000004308 accommodation Effects 0.000 description 1
- 235000011054 acetic acid Nutrition 0.000 description 1
- 229940069428 antacid Drugs 0.000 description 1
- 239000003159 antacid agent Substances 0.000 description 1
- 230000001458 anti-acid effect Effects 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 230000000711 cancerogenic effect Effects 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 231100000357 carcinogen Toxicity 0.000 description 1
- 239000003183 carcinogenic agent Substances 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 230000013872 defecation Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 235000021552 granulated sugar Nutrition 0.000 description 1
- 235000011167 hydrochloric acid Nutrition 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 230000003871 intestinal function Effects 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 235000015110 jellies Nutrition 0.000 description 1
- 239000008274 jelly Substances 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 1
- 239000000347 magnesium hydroxide Substances 0.000 description 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 229920001542 oligosaccharide Polymers 0.000 description 1
- 150000002482 oligosaccharides Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 239000013535 sea water Substances 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- -1 starch Chemical class 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 235000019640 taste Nutrition 0.000 description 1
Abstract
Description
【発明の詳細な説明】
（産業上の利用分野）
本発明は、難溶性のマグネシウム及びマグネシウム化合
物を高濃度含有するマグネシウム溶液の製造方法ならび
に、該マグネシウム溶液を使用した医薬品並びに加工食
品に関する。DETAILED DESCRIPTION OF THE INVENTION (Industrial Application Field) The present invention relates to a method for producing a magnesium solution containing a high concentration of poorly soluble magnesium and a magnesium compound, and to pharmaceuticals and processed foods using the magnesium solution.
（従来の技術及びその問題点）
マグネシウムは下記のような特徴を有するので、緩下剤
やその他の医薬品としても、又、栄養補給にも昔から使
用されてきた。(Prior art and its problems) Magnesium has the following characteristics and has long been used as a laxative and other medicines, as well as as a nutritional supplement.
■ 繊維と同様に保水効果がある。■ Like fiber, it has a water retention effect.
■ 大腸の水分吸収を抑えて便を軟かくしスムースに排
泄する。■ Suppresses water absorption in the large intestine, softens stool and allows for smooth excretion.
■ 飲みすぎても腹痛がおこらず副作用なし。■ Even if you drink too much, you won't get abdominal pain and there are no side effects.
■ 腔中の酸を中和し、歯を丈夫にし舌や日中のあれを
治す。■ Neutralizes acid in the cavity, strengthens teeth, and cures tongue and daytime irritation.
■ 胃酸を適正に調和し、胃壁の小さなタダレを治す。■ Properly balances stomach acid and cures small welts on the stomach wall.
■ 小腸内壁の炎症を治し、栄養の吸収を良くする。■ Cure inflammation in the lining of the small intestine and improve absorption of nutrients.
■ 腸の働きを活発にし、腸壁にこびりついた２ 宿便をとる。■ Activates intestinal function and gets stuck on the intestinal wall 2 Take accommodation.
■ 発ガン物質である一酸化炭素を消す。■ Eliminate carbon monoxide, a carcinogen.
■ 栄養素としてのマグネシウムの働き。■ Function of magnesium as a nutrient.
以上の如く、人体に於で上記のような特性を備え、こと
に便秘薬としては副作用も痛みも伴なわない最も理想的
な素材であるにもかかわらず、広く大衆に使用されてい
ないのは大量に飲まなければ効果が得られないうえ、非
常に現状の製品では飲みにくいためであるということが
わかった。As mentioned above, although it has the above-mentioned properties in the human body and is the most ideal material as a laxative with no side effects or pain, it is not widely used by the general public. It turns out that this is because the effect is not obtained unless you drink a large amount, and the current product is extremely difficult to swallow.
そこで、マグネシウム及びマグネシウム化合物を高濃度
で含有する液体とし、且つ、飲み易くするにはどうした
らよいかという点に着目して研究を重ねてきたが、その
研究を進める過程で最も大きな障害となったのは大量に
飲まなければならないのに（便秘の効果を得るためには
約２，０ ０ ０■を１回に飲む必要がある）マグネシ
ウム及びマグネシウム化合物の溶解度の低さという点で
ある。Therefore, research has focused on how to make a liquid that contains magnesium and magnesium compounds in high concentrations and make it easier to drink, but the biggest obstacle in the process of research has been The problem is the low solubility of magnesium and magnesium compounds, even though they have to be drunk in large quantities (approximately 2,000 square meters at a time to obtain the constipation effect).
従来下記に示す如く、クエン酸、リンゴ酸、酢酸、塩酸
、乳酸によりマグネシウム及びマグネシウム化合物の溶
解を試みたがマグネシウム及びマグネシウム化合物が高
濃度で含有し、かつ、飲み易い味の液体及び加工食品は
得られなかった。As shown below, attempts have been made to dissolve magnesium and magnesium compounds using citric acid, malic acid, acetic acid, hydrochloric acid, and lactic acid, but liquids and processed foods that contain high concentrations of magnesium and magnesium compounds and that are easy to drink have not been produced. I couldn't get it.
各１００ｃｃ溶剤 溶解量
クエン酸処理 ２００■
リンゴ酸処理 ８００ｍｇ
酢酸処理 ８００■
塩酸処理 １３００■
乳酸処理 ５００■ 当初溶解するが数日
で沈殿を生じ飲料用
として不可
又従来、水酸化マグネシウムを含有した乳液状の制酸緩
下剤は発売され公知である（製造元：株式会社三保製薬
研究所商品名スイマグ）。100 cc of each solvent Dissolution amount Citric acid treatment 200■ Malic acid treatment 800mg Acetic acid treatment 800■ Hydrochloric acid treatment 1300■ Lactic acid treatment 500■ Dissolves at first, but precipitates within a few days, making it unsuitable for use in beverages, and conventional emulsions containing magnesium hydroxide. This antacid laxative is commercially available and is well known (manufacturer: Miho Pharmaceutical Institute Co., Ltd., trade name: SUIMAG).
しかし乍ら、２，０ ０ ０＋ｎｇ飲まないと排便効果
が得られず、量が多いので錠剤でも水溶液でも飲み難く
、酸に可溶でも酸が強度であるため非常に飲用しにくい
。However, the defecation effect cannot be obtained unless 2,000+ng is taken, and the amount is so large that it is difficult to swallow whether it is a tablet or an aqueous solution, and even if it is soluble in acid, it is very difficult to drink because the acid is strong.
問題点
溶解量少ない
酸強く飲用不可
３
（発明の目的）
本発明は難溶性で、かつ、まずいマグネシウム及びマグ
ネシウム化合物を、極めて飲み易い状態又は食べやすい
状態で提供することを目的とする。Problems: Low dissolved amount, strong acidity, and non-drinkable 3 (Objective of the Invention) The object of the present invention is to provide poorly soluble and unpalatable magnesium and magnesium compounds in a state that is extremely easy to drink or eat.
（問題点を解決するための手段）
本発明は上記目的を達戊するためになされたもので、マ
グネシウム及びマグネシウム化合物を発酵乳酸に水溶液
の状態で溶解することにより、高濃度のマグネシウム及
びマグネシウム化合物を含有するマグネシウム液剤及び
該マグネシウム液剤を添加した飲料及び加工食品を得る
ことを見い出したものである。(Means for Solving the Problems) The present invention has been made to achieve the above object, and is capable of producing highly concentrated magnesium and magnesium compounds by dissolving magnesium and magnesium compounds in fermented lactic acid in the form of an aqueous solution. The present inventors have discovered that it is possible to obtain a magnesium solution containing the magnesium solution, and a beverage and processed food to which the magnesium solution is added.
（発明の好適態様）
醗酵乳酸
Ｗ６酵乳酸とはＣ３Ｈ６０３で表わされるもので、乳酸
をデンプンなどの糖類とともに乳酸菌をはたらかせるこ
とによって醗酵させたもので、式４
ＣＯＯＨ
ｌ
Ｈ Ｏ − Ｃ − Ｈ で表わされる光学活性型
ＬＣＨ３
（＋）乳酸が好適に使用される。(Preferred embodiment of the invention) Fermented lactic acid W6 Fermented lactic acid is represented by C3H603, and is produced by fermenting lactic acid by allowing lactic acid bacteria to work with sugars such as starch, and has the formula 4 COOH l H O - C - H. Optically active LCH3 (+) lactic acid as shown is preferably used.
醗酵乳酸は、刺激のない柔らかい厚い酸味を有している
ため、食品本来の味を損ねることがない。Fermented lactic acid has a soft, thick sour taste that is not irritating, so it does not impair the original taste of food.
本発明に用いるマグネシウム及びマグネシウム化合物は
天然に存在するもの（例えば、海水中のニガリ等）及び
工業用に合威されたもの何れでもよい。The magnesium and magnesium compound used in the present invention may be either naturally occurring (for example, bittern in seawater) or industrially synthesized.
ニガリについては鉄、カルシウム、硫黄分を微量含むが
溶解可能である。Bittern contains trace amounts of iron, calcium, and sulfur, but is soluble.
（実施例）
実施例１．
マグネシウム溶液製法の実施例
水８５ｃｃに対してマグネシウムの粉末（平均粒径２０
０メッシュ）２．０ｇｒを加え撹拌しマグネシウムの水
溶液を得た。(Example) Example 1. Example of magnesium solution manufacturing method Magnesium powder (average particle size 20
0 mesh) was added and stirred to obtain an aqueous solution of magnesium.
次に９“Ｏ％醗酵乳酸１５ｃｃを前記マグネシウムの水
溶液と混合した。これを３０℃の撹拌槽を有する恒温槽
で１０分間撹拌を行った後、常温で静置した所．１０週
間後に於でもマグネシウムの沈殿は全く認められず、し
かも厚味のあるたおやかな酸味を有する水溶性緩下剤が
得られた。Next, 15 cc of 9"O% fermented lactic acid was mixed with the magnesium aqueous solution. After stirring this for 10 minutes in a constant temperature bath with a 30°C stirring tank, it was left to stand at room temperature. After 10 weeks, No precipitation of magnesium was observed at all, and a water-soluble laxative having a thick, mild sour taste was obtained.
実施例２．
実施例１によって得られたマグネシウムの発酵乳酸水溶
液１ ０ ０ ｃｃに水飴２００ｇｒ、グラニュー糖２
００ｇｒを混合し、７５±５゜Ｃの温度でブリックスが
７５乃至７６になるまで加熱した後、加熱温度を６０℃
に下げ、そのま）静置した（原料１）。Example 2. To 100 cc of the fermented lactic acid aqueous solution of magnesium obtained in Example 1, 200 gr of starch syrup and 2 granulated sugar were added.
Mix 00gr and heat at a temperature of 75±5°C until the Brix reaches 75 to 76, then reduce the heating temperature to 60°C.
(raw material 1).
別の容器に寒天１５ｇｒ、水５００ｃｃを混ぜ、９０℃
で加熱を行い、その後、寒天の泡を除いてオリゴ糖５０
０ｇｒを加え、７５±５゜Ｃでブリックスが７５〜７６
になる迄、加熱を続けた（原料２）。Mix 15g of agar and 500cc of water in a separate container and bring to 90℃.
After that, remove the bubbles from the agar and add 50% oligosaccharide.
Add 0gr and Brix is 75-76 at 75±5°C
Heating was continued until it became (raw material 2).
次に原料１と原料２をよく混ぜ合わせ約６５℃の温度で
型に流し込み、ゼリー状に固化した７
ら取り出し規定の寸法にカットし、約４０’Ｃの乾燥機
で最終ブリックス８０になる迄、約２０時間乾燥した。Next, raw materials 1 and 2 were mixed well and poured into a mold at a temperature of about 65°C, and the solidified jelly-like material 7 was taken out and cut into specified sizes, and dried in a dryer at about 40'C until the final Brix was 80. , and dried for about 20 hours.
こうして得られたゼリーは１ ． ５ ａｎ Ｘ ３
ｄｌｌ Ｘ１．５印の寸法で重量は約３ｇｒである。そ
の一片につき約１００■のマグネシウムを含有する高濃
度のマグネシウム入り加工食品が得られた。The jelly thus obtained is 1. 5 an X 3
dll X1.5 mark size and weight is about 3gr. A highly concentrated magnesium-containing processed food containing about 100 μg of magnesium per piece was obtained.
Claims (5)
醗酵乳酸により溶解したマグネシウム溶液。(1) A magnesium solution in which highly concentrated magnesium and magnesium compounds are dissolved using fermented lactic acid.
醗酵乳酸により溶解したマグネシウム液剤。(2) A magnesium solution prepared by dissolving highly concentrated magnesium and magnesium compounds using fermented lactic acid.
醗酵乳酸により溶解した水溶液を添加した加工食品。(3) A processed food containing an aqueous solution of highly concentrated magnesium and magnesium compounds dissolved in fermented lactic acid.
醗酵乳酸により溶解した液状の緩下剤及びそれを用いて
製造した錠剤。(4) A liquid laxative in which highly concentrated magnesium and magnesium compounds are dissolved in fermented lactic acid, and tablets produced using the same.
食品。(5) A processed food containing the magnesium preparation according to claim 1.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1304889A JP2557111B2 (en) | 1989-11-27 | 1989-11-27 | Method for producing high-concentration magnesium solution, magnesium solution obtained thereby and use thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1304889A JP2557111B2 (en) | 1989-11-27 | 1989-11-27 | Method for producing high-concentration magnesium solution, magnesium solution obtained thereby and use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03168067A true JPH03168067A (en) | 1991-07-19 |
| JP2557111B2 JP2557111B2 (en) | 1996-11-27 |
Family
ID=17938503
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1304889A Expired - Lifetime JP2557111B2 (en) | 1989-11-27 | 1989-11-27 | Method for producing high-concentration magnesium solution, magnesium solution obtained thereby and use thereof |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2557111B2 (en) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07143863A (en) * | 1993-11-24 | 1995-06-06 | Maguoole Sci Kk | Method for producing magnesium-reinforced food |
| US8999313B2 (en) | 2012-09-11 | 2015-04-07 | Norgine Bv | Compositions |
| US9592252B2 (en) | 2011-03-11 | 2017-03-14 | Norgine Bv | Colonoscopy—preparation |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101420315B1 (en) | 2014-03-19 | 2014-07-17 | 남봉길 | Pharmaceutical liquid composition |
| RU2018105869A (en) | 2015-08-17 | 2019-09-19 | Ферринг Б.В. | LIQUID COMPOSITIONS CONTAINING PICOSULFATE AND MAGNESIUM CITRATE |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6055496A (en) * | 1983-09-07 | 1985-03-30 | 株式会社日立製作所 | Job direction/operation recorder |
| JPH01240174A (en) * | 1987-08-11 | 1989-09-25 | Pentlands Scotch Whisky Res Ltd | Food composition and its production |
-
1989
- 1989-11-27 JP JP1304889A patent/JP2557111B2/en not_active Expired - Lifetime
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6055496A (en) * | 1983-09-07 | 1985-03-30 | 株式会社日立製作所 | Job direction/operation recorder |
| JPH01240174A (en) * | 1987-08-11 | 1989-09-25 | Pentlands Scotch Whisky Res Ltd | Food composition and its production |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH07143863A (en) * | 1993-11-24 | 1995-06-06 | Maguoole Sci Kk | Method for producing magnesium-reinforced food |
| US9592252B2 (en) | 2011-03-11 | 2017-03-14 | Norgine Bv | Colonoscopy—preparation |
| US10646512B2 (en) | 2011-03-11 | 2020-05-12 | Norgine Bv | Colonoscopy - preparation |
| US10780112B2 (en) | 2011-03-11 | 2020-09-22 | Norgine Bv | Colonoscopy-preparation |
| US10792306B2 (en) | 2011-03-11 | 2020-10-06 | Norgine Bv | Colonoscopy—preparation |
| US11529368B2 (en) | 2011-03-11 | 2022-12-20 | Norgine Bv | Colonoscopy—preparation |
| US8999313B2 (en) | 2012-09-11 | 2015-04-07 | Norgine Bv | Compositions |
| US9326969B2 (en) | 2012-09-11 | 2016-05-03 | Norgine Bv | Compositions |
| US9707297B2 (en) | 2012-09-11 | 2017-07-18 | Norgine Bv | Compositions |
| US10016504B2 (en) | 2012-09-11 | 2018-07-10 | Norgine Bv | Compositions |
| US10918723B2 (en) | 2012-09-11 | 2021-02-16 | Norgine Bv | Colon cleansing compositions and methods of use |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2557111B2 (en) | 1996-11-27 |
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