CN103478732B - A kind of matrix sustained-release vitamin functional food and preparation method thereof - Google Patents
A kind of matrix sustained-release vitamin functional food and preparation method thereof Download PDFInfo
- Publication number
- CN103478732B CN103478732B CN201310464450.1A CN201310464450A CN103478732B CN 103478732 B CN103478732 B CN 103478732B CN 201310464450 A CN201310464450 A CN 201310464450A CN 103478732 B CN103478732 B CN 103478732B
- Authority
- CN
- China
- Prior art keywords
- vitamin
- release material
- water
- release
- gel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229940088594 vitamin Drugs 0.000 title claims abstract description 65
- 229930003231 vitamin Natural products 0.000 title claims abstract description 65
- 235000013343 vitamin Nutrition 0.000 title claims abstract description 65
- 239000011782 vitamin Substances 0.000 title claims abstract description 65
- 150000003722 vitamin derivatives Chemical class 0.000 title claims abstract description 60
- 239000011159 matrix material Substances 0.000 title claims abstract description 18
- 238000013268 sustained release Methods 0.000 title claims abstract description 17
- 239000012730 sustained-release form Substances 0.000 title claims abstract description 17
- 235000013376 functional food Nutrition 0.000 title claims abstract description 13
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 239000000463 material Substances 0.000 claims abstract description 47
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 38
- 235000013305 food Nutrition 0.000 claims abstract description 23
- 239000000843 powder Substances 0.000 claims abstract description 22
- 229920000297 Rayon Polymers 0.000 claims abstract description 19
- 235000021551 crystal sugar Nutrition 0.000 claims abstract description 16
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims abstract description 15
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims abstract description 15
- 239000000499 gel Substances 0.000 claims abstract description 14
- 239000007863 gel particle Substances 0.000 claims abstract description 12
- 239000000796 flavoring agent Substances 0.000 claims abstract description 11
- 235000019634 flavors Nutrition 0.000 claims abstract description 11
- 238000001816 cooling Methods 0.000 claims abstract description 9
- 239000000945 filler Substances 0.000 claims abstract description 9
- 239000002245 particle Substances 0.000 claims abstract description 9
- 238000004513 sizing Methods 0.000 claims abstract description 9
- 238000003756 stirring Methods 0.000 claims abstract description 9
- 238000009461 vacuum packaging Methods 0.000 claims abstract description 8
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims abstract description 7
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims abstract description 7
- 238000002156 mixing Methods 0.000 claims abstract description 7
- 238000003860 storage Methods 0.000 claims abstract description 7
- 239000006188 syrup Substances 0.000 claims abstract description 7
- 235000020357 syrup Nutrition 0.000 claims abstract description 7
- 241000206575 Chondrus crispus Species 0.000 claims abstract description 4
- 241000219112 Cucumis Species 0.000 claims abstract description 4
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 claims abstract description 4
- 108010010803 Gelatin Proteins 0.000 claims abstract description 4
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 claims abstract description 4
- 229920000159 gelatin Polymers 0.000 claims abstract description 4
- 239000008273 gelatin Substances 0.000 claims abstract description 4
- 235000019322 gelatine Nutrition 0.000 claims abstract description 4
- 235000011852 gelatine desserts Nutrition 0.000 claims abstract description 4
- 239000003292 glue Substances 0.000 claims abstract description 4
- 239000011573 trace mineral Substances 0.000 claims description 16
- 235000013619 trace mineral Nutrition 0.000 claims description 16
- GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 11
- 239000000084 colloidal system Substances 0.000 claims description 10
- 239000008101 lactose Substances 0.000 claims description 9
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 8
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 8
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 8
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
- LXNHXLLTXMVWPM-UHFFFAOYSA-N Vitamin B6 Natural products CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims description 5
- 229920006395 saturated elastomer Polymers 0.000 claims description 5
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 4
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims description 4
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims description 4
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 4
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims description 4
- 229930003268 Vitamin C Natural products 0.000 claims description 4
- 229930003316 Vitamin D Natural products 0.000 claims description 4
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 4
- 229930003427 Vitamin E Natural products 0.000 claims description 4
- 229930003448 Vitamin K Natural products 0.000 claims description 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 4
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims description 4
- 229910052802 copper Inorganic materials 0.000 claims description 4
- 239000010949 copper Substances 0.000 claims description 4
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 4
- 229910052742 iron Inorganic materials 0.000 claims description 4
- 239000011733 molybdenum Substances 0.000 claims description 4
- 229910052750 molybdenum Inorganic materials 0.000 claims description 4
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims description 4
- 239000011669 selenium Substances 0.000 claims description 4
- 229910052711 selenium Inorganic materials 0.000 claims description 4
- 235000019155 vitamin A Nutrition 0.000 claims description 4
- 239000011719 vitamin A Substances 0.000 claims description 4
- 235000019154 vitamin C Nutrition 0.000 claims description 4
- 239000011718 vitamin C Substances 0.000 claims description 4
- 235000019166 vitamin D Nutrition 0.000 claims description 4
- 239000011710 vitamin D Substances 0.000 claims description 4
- 150000003710 vitamin D derivatives Chemical class 0.000 claims description 4
- 235000019165 vitamin E Nutrition 0.000 claims description 4
- 239000011709 vitamin E Substances 0.000 claims description 4
- 229940046009 vitamin E Drugs 0.000 claims description 4
- 235000019168 vitamin K Nutrition 0.000 claims description 4
- 239000011712 vitamin K Substances 0.000 claims description 4
- 150000003721 vitamin K derivatives Chemical class 0.000 claims description 4
- 229940045997 vitamin a Drugs 0.000 claims description 4
- 229940046008 vitamin d Drugs 0.000 claims description 4
- 229940046010 vitamin k Drugs 0.000 claims description 4
- 239000011701 zinc Substances 0.000 claims description 4
- 229910052725 zinc Inorganic materials 0.000 claims description 4
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 claims description 3
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims description 3
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims description 3
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims description 3
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims description 3
- 229930003451 Vitamin B1 Natural products 0.000 claims description 3
- 229930003779 Vitamin B12 Natural products 0.000 claims description 3
- 229930003471 Vitamin B2 Natural products 0.000 claims description 3
- 229930003537 Vitamin B3 Natural products 0.000 claims description 3
- 229930003571 Vitamin B5 Natural products 0.000 claims description 3
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims description 3
- -1 hydroxyl isomaltulose Chemical compound 0.000 claims description 3
- 239000000905 isomalt Substances 0.000 claims description 3
- 235000010439 isomalt Nutrition 0.000 claims description 3
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 claims description 3
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 claims description 3
- 239000000845 maltitol Substances 0.000 claims description 3
- 235000010449 maltitol Nutrition 0.000 claims description 3
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical group OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 claims description 3
- 229940035436 maltitol Drugs 0.000 claims description 3
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 3
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims description 3
- 229960003495 thiamine Drugs 0.000 claims description 3
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims description 3
- 235000010374 vitamin B1 Nutrition 0.000 claims description 3
- 239000011691 vitamin B1 Substances 0.000 claims description 3
- 235000019163 vitamin B12 Nutrition 0.000 claims description 3
- 239000011715 vitamin B12 Substances 0.000 claims description 3
- 235000019164 vitamin B2 Nutrition 0.000 claims description 3
- 239000011716 vitamin B2 Substances 0.000 claims description 3
- 235000019160 vitamin B3 Nutrition 0.000 claims description 3
- 239000011708 vitamin B3 Substances 0.000 claims description 3
- 239000011675 vitamin B5 Substances 0.000 claims description 3
- 235000009492 vitamin B5 Nutrition 0.000 claims description 3
- 235000019158 vitamin B6 Nutrition 0.000 claims description 3
- 239000011726 vitamin B6 Substances 0.000 claims description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 2
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims description 2
- 229960002079 calcium pantothenate Drugs 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 2
- 239000011630 iodine Substances 0.000 claims description 2
- 229910052740 iodine Inorganic materials 0.000 claims description 2
- 229960003512 nicotinic acid Drugs 0.000 claims description 2
- 229960002477 riboflavin Drugs 0.000 claims description 2
- 238000007493 shaping process Methods 0.000 claims description 2
- 238000007873 sieving Methods 0.000 claims description 2
- 229940011671 vitamin b6 Drugs 0.000 claims description 2
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 1
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 claims 1
- 229930003756 Vitamin B7 Natural products 0.000 claims 1
- 229930003761 Vitamin B9 Natural products 0.000 claims 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- ZUFQODAHGAHPFQ-UHFFFAOYSA-N pyridoxine hydrochloride Chemical compound Cl.CC1=NC=C(CO)C(CO)=C1O ZUFQODAHGAHPFQ-UHFFFAOYSA-N 0.000 claims 1
- 235000011912 vitamin B7 Nutrition 0.000 claims 1
- 239000011735 vitamin B7 Substances 0.000 claims 1
- 235000019159 vitamin B9 Nutrition 0.000 claims 1
- 239000011727 vitamin B9 Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 7
- 239000011812 mixed powder Substances 0.000 abstract description 6
- 239000002994 raw material Substances 0.000 abstract description 5
- 238000004519 manufacturing process Methods 0.000 description 12
- 239000000306 component Substances 0.000 description 11
- 238000004090 dissolution Methods 0.000 description 9
- 239000000047 product Substances 0.000 description 9
- 238000000034 method Methods 0.000 description 7
- 239000013589 supplement Substances 0.000 description 5
- 235000012041 food component Nutrition 0.000 description 3
- 239000005428 food component Substances 0.000 description 3
- 239000000693 micelle Substances 0.000 description 3
- 238000012856 packing Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 235000000346 sugar Nutrition 0.000 description 3
- 102220487426 Actin-related protein 2/3 complex subunit 3_K15M_mutation Human genes 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 235000013361 beverage Nutrition 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 235000013373 food additive Nutrition 0.000 description 2
- 239000002778 food additive Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000035764 nutrition Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 208000000412 Avitaminosis Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 206010021135 Hypovitaminosis Diseases 0.000 description 1
- 241000700605 Viruses Species 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000011978 dissolution method Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000000017 hydrogel Substances 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000001502 supplementing effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 230000001256 tonic effect Effects 0.000 description 1
- 208000030401 vitamin deficiency disease Diseases 0.000 description 1
- 235000019195 vitamin supplement Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention provides a kind of matrix sustained-release vitamin functional food and preparation method thereof.Described raw-food material comprises vitamin and micro-mixed-powder, skeleton slow-release material, filler, water.The food made comprises gel particle, gel fourth and blob of viscose, and skeleton slow-release material is several or whole in the hydroxypropyl methylcellulose of hydrophilic gel, gelatin, carragheen, melon glue, shitosan.Mix after raw material are sieved, add water be stirred to micro-moistening after be machined into graininess or bulk, then through series of steps such as overcuring, be finally processed into particle or gel fourth carries out vacuum packaging storage.The preparation process of blob of viscose mixing and stirring again after dissolving for crystal sugar and slow-release material are added water respectively, vacuumize after being heated to 85 DEG C and carry out stirring off to finite concentration, add vitamin and micro-powder and flavor enhancement again, be uniformly mixed, the syrup mixed quantitatively dropped in mould and carry out sizing cooling and make blob of viscose.
Description
Technical field
The present invention relates to functional food field, particularly a kind of matrix sustained-release vitamin functional food and preparation method thereof.
Background technology
Vitamin maintains healthy necessary nutriment.Most of vitamin can not synthesize in human body, must be supplied by food.Human body is very little to the requirement of vitamin, and daily requirement often calculates with milligram (mg) or microgram (μ g), but human body is once be deficient in vitamin, and corresponding metabolic response will go wrong, thus produces vitamin-deficiency.Be deficient in vitamin and understand the body metabolism disequilibrium of let us, immunity degradation, various disease, virus will be availed oneself of the opportunity to get in.Vitamin is different from the large material of carbohydrate, fat and protein 3, only accounts for minor proportion, really again by human body is required in natural food.
Trace element in vivo content is considerably less, but their effects in life process can not be underestimated.Do not have the trace element that these are required, the activity of enzyme will reduce or completely lose, and the synthesis of hormone, protein, vitamin and metabolism also obstacle will occur, and human life's process is just difficult to proceed.
Multivitamin and supplementing of trace element are that present people pursues healthy significant concern project always, in daily life except tonic, most people can prefer the nutriment selecting to eat a certain amount of multivitamin, Cernevit-12 etc. type every day, needed for ensureing that health normally with this, this is also more convenient mode efficiently.
But most of vitamin supplement product of market today is due to the unstability of vitamin itself, add that in manufacturing process, other raw material can not avoid this shortcoming well, if do not eaten as early as possible behind Kaifeng, just can there is the reactions such as oxidation after placing a period of time and produce the similar rotten phenomenons such as variable color, the absorptivity that such vitamin takes rear human body reduces greatly, thus really can not reach the object of reasonable supplement nutrition.
Therefore, appropriate vitamin can be supplemented easily at any time to meet people, needing stability and the storage time of improving vitamin products as far as possible, guaranteeing that vitamin continues slow stripping, be beneficial to absorption of human body, and ensure good mouthfeel as far as possible.Also be necessary to improve raw materials for production and technique, should ensure content and the stability of vitamin, low cost is beneficial to production again simultaneously.
Summary of the invention
The invention provides a kind of matrix sustained-release vitamin functional food and preparation method thereof, can solve the problem well.Described matrix sustained-release vitamin functional food comprises vitamin and micro-mixed-powder, skeleton slow-release material, packing material, water, wherein vitamin comprises vitamin A, vitamin C, vitamin D, vitamin E, vitamin B1, B2, B3, B5, B6, B7 (H), B9, B12, several or whole in vitamin K, also comprise trace copper, iodine, iron, molybdenum, selenium, zinc several or whole, it is characterized in that: skeleton slow-release material is the hydroxypropyl methylcellulose of hydrophilic gel, gelatin, carragheen, melon glue, several or whole in shitosan, described food form is gel particle, gel fourth, blob of viscose, and the total content of every 1kg food vitamins and trace element is 3-4g.
Wherein in 1kg gel particle or gel fourth, the content of vitamin and micro-mixed-powder, skeleton slow-release material, packing material, water is respectively 3-4g, 600-650g, 50-100g, 280-350g, shared gross weight ratio be respectively 0.3%-0.4%, 60%-65%, 5%-10%, 28%-35%.
In described blob of viscose, crystal sugar accounts for the 35-50% of blob of viscose gross weight, and skeleton slow-release material accounts for the 25-50% of gross weight, and flavor enhancement accounts for the 5-10% of gross weight, and water accounts for the 5-20% of gross weight, and vitamin and micro-mixed-powder account for the 0.3-0.4% of gross weight.As preferably, crystal sugar is maltitol, hydroxyl isomaltulose, isomalt, reduced isomaltooligosaccharide, the one or more combination in liquid glucose etc.Flavor enhancement according to the needs producing product, can add suitable sweetener, acid etc.
In every 1kg food, various vitamin and trace element are optionally according to proportioning interpolation below: vitamin A 0.01875g-0.03125g; Vitamin C 1.125-1.75g; Vitamin D 0.00025-0.000375g; Vitamin E 0.1875-0.3125g; VitaminB10 .03125-0.04375g; Vitamin B2 0.03125-0.04375g; Vitamin B3 0.3125-0.375 μ g; Vitamin B5 0.10625-0.11875g; Vitamin B6 0.03125-0.04375g; VB7 0.625-0.75g; FA 0.0125-0.01875g; Vitamin B12 500-750g; Vitamin K 0.0025-0.005g; Copper 0.01875-0.025g, iodine 0.0025-0.00375g, iron 0.25-0.375g, molybdenum 750-1000 μ g, selenium 0.00125-0.0025g, zinc 0.1875-0.25g.According to product mainly for supplementary crowd different, the food containing above several vitamins and several trace element can be produced, also can produce the food that with the addition of above all elements, the rational like this demand according to market crowd, thus produce dissimilar multielement nutrition supplement.
Present invention also offers the preparation method of two kinds of matrix sustained-release vitamin functional food, the method wherein preparing particle and gel fourth is:
(1) vitamin and micro-mixed-powder, sustained-release matrix material, packing material are mixed after sieving respectively, add water stir micro-moistening after be machined into the colloid of 2-7mm graininess or bulk;
(2) shaping colloid is dropped in 70 DEG C of water and carries out slaking, be separated from hot bath after 10 minutes, then drop in 4 DEG C of saturated D/Ws carry out sizing cooling;
(3) by cooled colloid drain well in desinfection chamber, graininess colloid can vacuum packaging immediately, and block colloid, through being cut into gel fourth final vacuum packaging, finally keeps in cold storage.
Another is the method preparing blob of viscose food:
(1) added water by crystal sugar and dissolve, it is different and different that the addition of water looks the use amount of crystal sugar;
(2) sustained-release matrix material is dissolved in water, in order to accelerate the speed of dissolving, 80 DEG C can be heated, dissolve rear filtration completely;
(3), by the sustained-release matrix material of dissolving and liquid glucose mixing and stirring, be heated to 85 DEG C, vacuumize and stir off, take the dish out of the pot concentration to 80%;
(4) by vitamin and micro-mixed-powder, flavor enhancement is fed in the syrup boiled, be uniformly mixed, the syrup mixed quantitatively is dropped in mould and carry out sizing cooling, the low blob of viscose structure of the concentration that takes the dish out of the pot according to demand (depending on soft or hard degree), unnecessary moisture need be removed through bake process, increase toughness.
Skeleton slow-release material of the present invention is hydrogel matrix slow-release material, several or whole preferably in hydroxypropyl methylcellulose, gelatin, carragheen, melon glue, shitosan, and described filler is lactose.
When adding maltitol in production, hydroxyl isomaltulose, isomalt, reduced isomaltooligosaccharide, after one or more in liquid glucose etc., sharply raises owing to can't produce blood sugar, so be also applicable to diabetic to take, for it provides certain heat.
Product of the present invention can directly eat, and also can be used as food additives and joins in other foods edible, directly can also join in various beverage according to personal like, the nutrient product of vitamin and various trace elements as a supplement.Adult's amount every day is no more than 30g.
Skeleton slow-release function vitamin food of the present invention, has the following advantages:
(1) owing to adding skeleton slow-release material at raw material, be conducive to health and better absorb vitamin and trace element, and there is good stability, can ensure that vitamin and trace element discharge gradually, can keep within a certain period of time discharging slowly, well like this overcome the unstable shortcoming of absorption of human body difference, product.
(2) can supplement needed by human body multivitamin and trace element, production method technique provided by the invention is simple simultaneously, and the cost of raw material is cheap, is easy to industrialization.
(3) owing to adding low sugar crystal sugar low in calories in the production of gel piece food, blood sugar can not be caused sharply to raise, also be applicable to diabetes patient, for it provides certain heat.
(4) product of the present invention can directly eat, and also can be used as food additives and joins in other foods edible, directly can also join in various beverage according to personal like, the nutrient product of vitamin and various trace elements as a supplement.
Accompanying drawing explanation
Dissolution experiments curve plotting: test according to the related request of Chinese Pharmacopoeia 2,010 second annex X C dissolution methods, respectively sampling in 0,2,4,6 hour, data after 6 hours every 15 minutes records once, until obtain corresponding time point when composition all dissolves, with dissolution time and dissolving per cents curve.
Accompanying drawing 1: be the Dissolution profiles of R1 in embodiment 1, show under a certain amount of slow-release material, the dissolution velocity of all the components in gel particle.
Accompanying drawing 2,3,4: be group correlation curve figure of three in embodiment 2, show that the dissolution velocity of various composition in gel particle slows down gradually along with the increase of slow-release material addition, the consoluet time also extends gradually.
Accompanying drawing 5,6,7: be three groups of correlation curve figure in embodiment 3, show after with the addition of the HPMC of different model, the dissolution velocity change of composition in gel particle
Accompanying drawing 8,9,10: be three groups of correlation curve figure in embodiment 4, show after the model of HPMC changes successively in blob of viscose, the also corresponding increase of the complete dissolution time of all the components.
Accompanying drawing 11,12,13: be three groups of correlation curve figure in embodiment 5, shows that the dissolution velocity of all the components is corresponding to slow down after the slow-release material added in blob of viscose increases.
Accompanying drawing 14: be the solubility curve figure of R16 in embodiment 6, after showing to the addition of a certain amount of slow-release material in blob of viscose, the dissolution velocity change of ingredient.
Detailed description of the invention
It is vitamin and micro-powder 4g, slow-release material 600g, lactose 90g, water 306g that embodiment 1 prepares the component of gel particle R1 food that 1kg3 kind adds different types of vitamin and trace element respectively.
The component of R2 food is vitamin and micro-powder 3.85g, slow-release material 600g, lactose 90g, 306.15g.
The component of R3 food is vitamin and micro-powder 3g, slow-release material 600g, lactose 90g, water 307g.
Further elements proportioning is as following table 1.
Production method: mix after vitamin and micro-powder, framework material, filler are sieved respectively, add water be stirred to micro-moistening after be machined into the particle of diameter 2mm, particle is dropped in 70 DEG C of water and carry out slaking, be separated from hot bath after 10 minutes, drop into again in 4 DEG C of saturated D/Ws and carry out sizing cooling, cooled micelle drain well in desinfection chamber, vacuum packaging immediately, keeps in cold storage.
Table 1
Embodiment 2 prepares the gel particle that 1kg3 kind with the addition of different slow-release material amount respectively
R4 food component is vitamin and micro-powder 4g, slow-release material 600g, lactose 100g, water 300g.
R5 food component is vitamin and micro-powder 4g, slow-release material 616g, lactose 100g, water 280g.
R6 food component is vitamin and micro-powder 4g, slow-release material 650g, lactose 100g, water 246g.
Further elements proportioning is as following table 2.
Production method: mix after vitamin and micro-powder, framework material, filler are sieved respectively, add water be stirred to micro-moistening after be machined into the particle of diameter 7mm, particle is dropped in 70 DEG C of water and carry out slaking, be separated from hot bath after 10 minutes, drop into again in 4 DEG C of saturated D/Ws and carry out sizing cooling, cooled micelle drain well in desinfection chamber, vacuum packaging immediately, keeps in cold storage.
Table 2
Embodiment 3 prepares the gel particle that 1kg3 kind with the addition of the hydroxypropyl methylcellulose mixing slow-release material of different model respectively
The component of R7, R8, R9 food is vitamin and micro-powder 4g, slow-release material 600g, lactose 50g, water 350g, and the HPMC wherein in slow-release material adopts model HPMC K15M, HPMCK4M, HPMC K100M successively.Detailed component proportion is as following table 3.
Production method: mix after vitamin and micro-powder, framework material, filler are sieved respectively, add water be stirred to micro-moistening after be machined into the particle of diameter 5mm, particle is dropped in 70 DEG C of water and carry out slaking, be separated from hot bath after 10 minutes, drop into again in 4 DEG C of saturated D/Ws and carry out sizing cooling, cooled micelle drain well in desinfection chamber, vacuum packaging immediately, keeps in cold storage.
Table 3
Embodiment 4 prepares the blob of viscose that 1kg3 kind with the addition of the hydroxypropyl methylcellulose mixing slow-release material of different model respectively
R10, R11, R12 food vitamins and micro-powder are 4g, slow-release material is 492g, flavor enhancement 50g, crystal sugar 300g, water 154g, and wherein the model of hydroxypropyl methylcellulose is followed successively by HPMC K4M, HPMC K15M, HPMC K100M.
Detailed component proportion is as following table 4.
Production method: crystal sugar is added water and dissolves, it is different and different that the addition of water looks the use amount of crystal sugar; Sustained-release matrix material is dissolved in water, in order to accelerate the speed of dissolving, 80 DEG C can be heated to, refilters after slow-release material dissolves completely; By the sustained-release matrix material of dissolving and liquid glucose mixing and stirring, be heated to 80 DEG C, vacuumize and stir off, take the dish out of the pot concentration to 80%, and by vitamin and micro-powder, flavor enhancement is fed in the syrup boiled, and is uniformly mixed; Quantitatively dropped into by the syrup mixed in mould and carry out sizing cooling, the blob of viscose structure of the concentration that takes the dish out of the pot according to demand, can be passed through baking and removes unnecessary moisture, increase toughness.
Table 4
Embodiment 5 prepare respectively 1kg3 kind with the addition of blob of viscose R13, R14, R15 food vitamins of different mixing slow-release material amount and micro-powder be 4g, crystal sugar 450g, slow-release material be followed successively by 250g, 310g, 320g, flavor enhancement 96g, water 200g.
Detailed component proportion is as following table 5.
Production method is identical with embodiment 4.
Table 5
Embodiment 6 prepare respectively 1kg3 kind with the addition of vitamin not of the same race and trace element blob of viscose R16, R17, R18 food vitamins and micro-powder be followed successively by 4g, 3.85g, 3g, slow-release material 392g, flavor enhancement is followed successively by 74g, 74.15g, 75g, crystal sugar 300g, water 200g.
Detailed component proportion is as following table 6.
Production method is identical with embodiment 4.
Table 6
Claims (5)
1. a matrix sustained-release vitamin functional food, comprise vitamin powder, skeleton slow-release material, water, the combination of filler or the combination of vitamin powder, skeleton slow-release material, water, crystal sugar and flavor enhancement, wherein vitamin powder contains vitamin A, vitamin C, vitamin D, vitamin E, vitamin B1, B2, B3, B5, B6, B7, B9, B12 and vitamin K, also containing trace copper, iodine, iron, molybdenum, selenium and zinc; It is characterized in that: skeleton slow-release material is the hydroxypropyl methylcellulose of hydrophilic gel, gelatin, carragheen, melon glue and shitosan; Described food form is gel particle, gel fourth, blob of viscose; Described gel particle or gel fourth comprise vitamin and trace element, skeleton slow-release material, filler, water, and shared ratio is respectively 0.3%-0.4%, 60%-65%, 5%-10%, 28%-35% of gross weight; Described blob of viscose comprises vitamin and trace element, skeleton slow-release material, crystal sugar, flavor enhancement, water, the 0.3%-0.4% of shared ratio difference gross weight, 25%-50%, 30%-45%, 5%-20%, 5%-10%;
The preparation method of described gel particle and gel fourth is: by vitamin powder and micro-powder, skeleton slow-release material, filler mixes after sieving respectively, add water be stirred to micro-moistening after be machined into the colloid of graininess or bulk, shaping colloid is dropped in 70 ° of C water and carry out slaking, be separated from hot bath after 10 minutes, drop in 4 ° of saturated D/Ws of C and carry out sizing cooling, cooled colloid drain well in desinfection chamber, the vacuum packaging immediately of graininess colloid, block colloid is through being processed as gel fourth final vacuum packaging, finally keep in cold storage,
The preparation process of described blob of viscose is dissolved for being added water by crystal sugar, and it is different and different that the addition of water looks the use amount of crystal sugar; Skeleton slow-release material is dissolved in water, in order to accelerate the speed of dissolving, is heated to uniform temperature, dissolves rear filtration completely to slow-release material; By the skeleton slow-release material of dissolving and liquid glucose mixing and stirring, be heated to 85 DEG C, vacuumize and stir off, take the dish out of the pot concentration to 80%, and by vitamin powder and micro-powder, flavor enhancement is fed in the syrup boiled, and is uniformly mixed; Quantitatively dropped into by the syrup mixed in mould and carry out sizing cooling, the blob of viscose structure of the concentration that takes the dish out of the pot according to demand, removes unnecessary moisture through overbaking, increases toughness.
2. according to the matrix sustained-release vitamin functional food described in claim 1, it is characterized in that: in every 1kg food, various vitamin and trace element add according to addition below:
Vitamin A 18.75-31.25mg vitamin C 1125-1750mg
Vitamin D 0.25-0.375mg vitamin E 187.5-312.5mg
Vitamin B1 31.25-43.75mg vitamin B2 31.25-43.75mg
Vitamin B3 312.5-375mg vitamin B5 106.25-118.75mg
Vitamin B6 31.25-43.75mg VB7 625-750mg
FA 12.5-18.75mg vitamin B12 0.5-0.75mg
Vitamin K 2.5-6mg copper 18.75-25mg
Iodine 2.5-3.75mg, iron 250-375mg, molybdenum 0.75-1mg, selenium 1.25-2.5mg,
Zinc 187.5-250mg.
3. according to the matrix sustained-release vitamin functional food described in claim 1, it is characterized in that: described food granule particle diameter is 2-7mm.
4. according to the matrix sustained-release vitamin functional food described in claim 1, it is characterized in that: crystal sugar is maltitol, hydroxyl isomaltulose, isomalt, reduced isomaltooligosaccharide, the one or more combination in liquid glucose.
5., according to the arbitrary described matrix sustained-release vitamin functional food of claim 1 or 2 or 3, it is characterized in that: described filler is lactose.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310464450.1A CN103478732B (en) | 2013-09-30 | 2013-09-30 | A kind of matrix sustained-release vitamin functional food and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310464450.1A CN103478732B (en) | 2013-09-30 | 2013-09-30 | A kind of matrix sustained-release vitamin functional food and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103478732A CN103478732A (en) | 2014-01-01 |
| CN103478732B true CN103478732B (en) | 2015-08-19 |
Family
ID=49819594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310464450.1A Active CN103478732B (en) | 2013-09-30 | 2013-09-30 | A kind of matrix sustained-release vitamin functional food and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103478732B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104544459A (en) * | 2015-01-08 | 2015-04-29 | 天津科技大学 | Solid beverage controlled-release particle and preparation method thereof |
| CN106491565B (en) * | 2016-12-16 | 2019-01-22 | 江苏艾兰得营养品有限公司 | A kind of vitamin C zincification sustained-release pellet preparation and preparation method thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1274580A (en) * | 1999-05-20 | 2000-11-29 | 杭州阳光文化用品有限公司 | Stable delayed vitamin C preparation and its production process |
| CN1582922A (en) * | 2003-08-20 | 2005-02-23 | 范敏华 | Sustained releasing preparation of vilamin C and its preparing method |
| DE202005004706U1 (en) * | 2005-03-08 | 2006-04-20 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Composition, useful for peroral application with direct release of active substances, comprises multiplicity and/or a combination of active substances (preferably e.g. vitamins) that are incorporated or stored in a swellable matrix |
| CN101249081A (en) * | 2008-02-15 | 2008-08-27 | 南京大渊美容保健有限公司 | Administer orally controlled release drug administration pharmaceutical tablet |
| CN101322778A (en) * | 2008-07-22 | 2008-12-17 | 北京康比特体育科技股份有限公司 | Double-layer sustained release tablets for compensating iron and preparation thereof |
| CN102271664A (en) * | 2009-01-23 | 2011-12-07 | 方济各安吉利克化学联合股份有限公司 | Controlled release pharmaceutical or food formulation and process for its preparation |
| CN102579318A (en) * | 2011-01-10 | 2012-07-18 | 杭州赛利药物研究所有限公司 | Stable vitamin C sustained release preparation and preparation method thereof |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102550774B (en) * | 2011-12-29 | 2013-06-05 | 广东仙乐制药有限公司 | Sugar-free nutrient soft candy containing vitamin C and preparation method of same |
-
2013
- 2013-09-30 CN CN201310464450.1A patent/CN103478732B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1274580A (en) * | 1999-05-20 | 2000-11-29 | 杭州阳光文化用品有限公司 | Stable delayed vitamin C preparation and its production process |
| CN1582922A (en) * | 2003-08-20 | 2005-02-23 | 范敏华 | Sustained releasing preparation of vilamin C and its preparing method |
| DE202005004706U1 (en) * | 2005-03-08 | 2006-04-20 | Maria Clementine Martin Klosterfrau Vertriebsgesellschaft Mbh | Composition, useful for peroral application with direct release of active substances, comprises multiplicity and/or a combination of active substances (preferably e.g. vitamins) that are incorporated or stored in a swellable matrix |
| CN101249081A (en) * | 2008-02-15 | 2008-08-27 | 南京大渊美容保健有限公司 | Administer orally controlled release drug administration pharmaceutical tablet |
| CN101322778A (en) * | 2008-07-22 | 2008-12-17 | 北京康比特体育科技股份有限公司 | Double-layer sustained release tablets for compensating iron and preparation thereof |
| CN102271664A (en) * | 2009-01-23 | 2011-12-07 | 方济各安吉利克化学联合股份有限公司 | Controlled release pharmaceutical or food formulation and process for its preparation |
| CN102579318A (en) * | 2011-01-10 | 2012-07-18 | 杭州赛利药物研究所有限公司 | Stable vitamin C sustained release preparation and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 廖洪娟,等.维生素C缓释片的制备工艺研究.《天津药学》.2012,第24卷(第5期),第9-12页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103478732A (en) | 2014-01-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR102012305B1 (en) | Sugar composition mainly composed of sucrose and d-psicose, and method for producing same | |
| CN101548698B (en) | Humanized milk and preparation method thereof | |
| CN105379927B (en) | A kind of sugar-free hard candy low in calories and preparation method thereof containing antierythrite | |
| JP4702745B2 (en) | Mineral absorption promoter and its use | |
| CN102599394A (en) | Preparation method for jelly | |
| CN102106495A (en) | Konjac jelly powder and method for making jellies by using same | |
| CN106071519B (en) | Add the nutrient drinks and preparation method thereof of gel particle | |
| CN102524619B (en) | Energy sustained-release nutritional jelly using konjaku flour as carrier and preparation thereof | |
| CN103330208A (en) | Double-protein nutrient chewing tablet capable of raising spirit and preparation method thereof | |
| KR20130137199A (en) | Food containing milk ceramide, and process for production thereof | |
| CN102652525A (en) | L-pectinose function hard candy and preparation method thereof | |
| CN104304609A (en) | Donkey-hide gelatin and inulin soft sweets and preparation method therefor | |
| CN103478732B (en) | A kind of matrix sustained-release vitamin functional food and preparation method thereof | |
| JP5721616B2 (en) | Method for producing gel food / beverage product composition and gelling agent | |
| CN106036678A (en) | Jellies capable of slow release of energy and preparation method of jellies | |
| JP4583352B2 (en) | Manufacturing method of energy supplement jelly | |
| JP2013132284A (en) | Gelling agent for food or beverage | |
| CN102028191B (en) | Sugar-free ginger beverage with black fungus grain | |
| CN110063462A (en) | A kind of preparation process of egg-white powder jelly | |
| JP2013208103A (en) | Regular diet-like jelly-in-jelly | |
| CN109090319A (en) | Newborn mineral salt pressed candy | |
| CN102613459B (en) | Compound moisturizing agent for foods and preparation method thereof | |
| CN104186883A (en) | Preparation method of functional milk candy with L-arabinose | |
| CN102835692B (en) | Preparation method of ready-to-eat spirulina granule preserved at room temperature | |
| JP6042610B2 (en) | Gelling agent for protein-containing food and drink |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant |