JP2025516501A - Ｉｒａｋ４修飾化合物による疾患及び障害の治療 - Google Patents

Ｉｒａｋ４修飾化合物による疾患及び障害の治療 Download PDF

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JP2025516501A
JP2025516501A JP2024564822A JP2024564822A JP2025516501A JP 2025516501 A JP2025516501 A JP 2025516501A JP 2024564822 A JP2024564822 A JP 2024564822A JP 2024564822 A JP2024564822 A JP 2024564822A JP 2025516501 A JP2025516501 A JP 2025516501A
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biomarker
irak4
expression level
subject
sample
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JP2025516501A5 (enExample
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ウゴルコフ，アンドレイ
マーテル，ロバート
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キュリス，インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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JP2024564822A 2022-05-11 2023-05-11 Ｉｒａｋ４修飾化合物による疾患及び障害の治療 Pending JP2025516501A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263340692P 2022-05-11 2022-05-11
US63/340,692 2022-05-11
PCT/US2023/021812 WO2023220227A1 (en) 2022-05-11 2023-05-11 Treating diseases and disorders with irak4-modifying compounds

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JP2025516501A true JP2025516501A (ja) 2025-05-30
JP2025516501A5 JP2025516501A5 (enExample) 2026-05-19

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JP2024564822A Pending JP2025516501A (ja) 2022-05-11 2023-05-11 Ｉｒａｋ４修飾化合物による疾患及び障害の治療

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EP (1) EP4522772A4 (enExample)
JP (1) JP2025516501A (enExample)
KR (1) KR20250011914A (enExample)
CN (1) CN119156458A (enExample)
AU (1) AU2023269214A1 (enExample)
CA (1) CA3251930A1 (enExample)
IL (1) IL316793A (enExample)
MX (1) MX2024013649A (enExample)
WO (1) WO2023220227A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SMT202400142T1 (it) 2014-01-13 2024-05-14 Aurigene Oncology Ltd Enantiomeri (r) e (s) di n-(5-(3-idrossipirrolidin-1-il)-2-morfolinoossazolo[4,5-b]piridin-6-il)-2-(2-metilpiridin-4-il)ossazolo-carbossammide in qualità di inibitori di irak4 per il trattamento di un cancro
US12178821B2 (en) 2021-04-08 2024-12-31 Curis, Inc. Combination therapies for the treatment of cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818419B2 (en) * 2000-01-13 2004-11-16 Tularik Inc. IRAK-4: compositions and methods of use
WO2013042137A1 (en) * 2011-09-19 2013-03-28 Aurigene Discovery Technologies Limited Bicyclic heterocycles as irak4 inhibitors
CN108024971A (zh) * 2015-07-15 2018-05-11 奥列基因发现技术有限公司 作为irak-4抑制剂的取代的氮杂化合物
CN120267671A (zh) * 2017-03-31 2025-07-08 奥锐金肿瘤有限公司 用于治疗血液病的化合物和组合物
MX2020003666A (es) * 2017-10-31 2020-08-03 Curis Inc Compuestos y composiciones para el tratamiento de trastornos hematologicos.
KR20230048358A (ko) * 2020-08-03 2023-04-11 쿠리스 인코퍼레이션 질환 및 장애를 치료하기 위한 조성물 및 방법
WO2022108996A1 (en) * 2020-11-18 2022-05-27 Curis, Inc. Methods of treating diseases and disorders

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Publication number Publication date
KR20250011914A (ko) 2025-01-22
WO2023220227A1 (en) 2023-11-16
EP4522772A1 (en) 2025-03-19
CA3251930A1 (en) 2023-11-16
MX2024013649A (es) 2024-12-06
EP4522772A4 (en) 2026-04-22
IL316793A (en) 2025-01-01
CN119156458A (zh) 2024-12-17
AU2023269214A1 (en) 2024-10-10

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