IL316793A - Treating diseases and disorders with compounds that modify IRAK4 - Google Patents
Treating diseases and disorders with compounds that modify IRAK4Info
- Publication number
- IL316793A IL316793A IL316793A IL31679324A IL316793A IL 316793 A IL316793 A IL 316793A IL 316793 A IL316793 A IL 316793A IL 31679324 A IL31679324 A IL 31679324A IL 316793 A IL316793 A IL 316793A
- Authority
- IL
- Israel
- Prior art keywords
- subject
- irak4
- irakinhibitor
- following administration
- biological sample
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
- A61K31/175—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine having the group, >N—C(O)—N=N— or, e.g. carbonohydrazides, carbazones, semicarbazides, semicarbazones; Thioanalogues thereof
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
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- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US202263340692P | 2022-05-11 | 2022-05-11 | |
| PCT/US2023/021812 WO2023220227A1 (en) | 2022-05-11 | 2023-05-11 | Treating diseases and disorders with irak4-modifying compounds |
Publications (1)
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|---|---|
| IL316793A true IL316793A (en) | 2025-01-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL316793A IL316793A (en) | 2022-05-11 | 2023-05-11 | Treating diseases and disorders with compounds that modify IRAK4 |
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| US (1) | US20260183301A1 (enExample) |
| EP (1) | EP4522772A4 (enExample) |
| JP (1) | JP2025516501A (enExample) |
| KR (1) | KR20250011914A (enExample) |
| CN (1) | CN119156458A (enExample) |
| AU (1) | AU2023269214A1 (enExample) |
| CA (1) | CA3251930A1 (enExample) |
| IL (1) | IL316793A (enExample) |
| MX (1) | MX2024013649A (enExample) |
| WO (1) | WO2023220227A1 (enExample) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL311677B2 (en) | 2014-01-13 | 2025-06-01 | Aurigene Oncology Ltd | Bicyclic heterocyclyl derivatives as irak4 inhibitors |
| CA3214747A1 (en) | 2021-04-08 | 2022-10-13 | Reinhard Von Roemeling | Combination therapies for the treatment of cancer |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6818419B2 (en) * | 2000-01-13 | 2004-11-16 | Tularik Inc. | IRAK-4: compositions and methods of use |
| WO2013042137A1 (en) * | 2011-09-19 | 2013-03-28 | Aurigene Discovery Technologies Limited | Bicyclic heterocycles as irak4 inhibitors |
| EP3322409A4 (en) * | 2015-07-15 | 2019-07-24 | Aurigene Discovery Technologies Limited | SUBSTITUTED AZA COMPOUNDS AS IRAQ-4 INHIBITORS |
| CN120267671A (zh) * | 2017-03-31 | 2025-07-08 | 奥锐金肿瘤有限公司 | 用于治疗血液病的化合物和组合物 |
| EP4410377A3 (en) * | 2017-10-31 | 2024-11-13 | Curis, Inc. | Compounds and compositions for treating hematological disorders |
| AU2021321350A1 (en) * | 2020-08-03 | 2023-03-16 | Curis, Inc. | Compositions and methods for treating diseases and disorders |
| CA3199157A1 (en) * | 2020-11-18 | 2022-05-27 | Reinhard Von Roemeling | Methods of treating diseases and disorders |
-
2023
- 2023-05-11 CA CA3251930A patent/CA3251930A1/en active Pending
- 2023-05-11 JP JP2024564822A patent/JP2025516501A/ja active Pending
- 2023-05-11 IL IL316793A patent/IL316793A/en unknown
- 2023-05-11 MX MX2024013649A patent/MX2024013649A/es unknown
- 2023-05-11 AU AU2023269214A patent/AU2023269214A1/en active Pending
- 2023-05-11 EP EP23804237.8A patent/EP4522772A4/en active Pending
- 2023-05-11 US US18/864,799 patent/US20260183301A1/en active Pending
- 2023-05-11 WO PCT/US2023/021812 patent/WO2023220227A1/en not_active Ceased
- 2023-05-11 KR KR1020247040259A patent/KR20250011914A/ko active Pending
- 2023-05-11 CN CN202380038247.XA patent/CN119156458A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN119156458A (zh) | 2024-12-17 |
| WO2023220227A1 (en) | 2023-11-16 |
| EP4522772A1 (en) | 2025-03-19 |
| CA3251930A1 (en) | 2023-11-16 |
| MX2024013649A (es) | 2024-12-06 |
| JP2025516501A (ja) | 2025-05-30 |
| US20260183301A1 (en) | 2026-07-02 |
| AU2023269214A1 (en) | 2024-10-10 |
| KR20250011914A (ko) | 2025-01-22 |
| EP4522772A4 (en) | 2026-04-22 |
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