JP2025514858A - ＳＡＲＳ－ＣｏＶ－２抗体、及びその使用方法 - Google Patents

ＳＡＲＳ－ＣｏＶ－２抗体、及びその使用方法 Download PDF

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Publication number
JP2025514858A
JP2025514858A JP2024563287A JP2024563287A JP2025514858A JP 2025514858 A JP2025514858 A JP 2025514858A JP 2024563287 A JP2024563287 A JP 2024563287A JP 2024563287 A JP2024563287 A JP 2024563287A JP 2025514858 A JP2025514858 A JP 2025514858A
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JP
Japan
Prior art keywords
antibody
antigen
binding fragment
seq
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024563287A
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English (en)
Japanese (ja)
Other versions
JP2025514858A5 (enExample
Inventor
コーエン，テイラー
フランシカ，ジョー
ラジャン，セラバン
カプラン，ギラッド
ツァイ，インユン
ディッペル，アンドリュー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
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AstraZeneca UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca UK Ltd filed Critical AstraZeneca UK Ltd
Publication of JP2025514858A publication Critical patent/JP2025514858A/ja
Publication of JP2025514858A5 publication Critical patent/JP2025514858A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/102—Coronaviridae (F)
    • C07K16/104—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/165—Coronaviridae, e.g. avian infectious bronchitis virus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2024563287A 2022-04-29 2023-04-28 ＳＡＲＳ－ＣｏＶ－２抗体、及びその使用方法 Pending JP2025514858A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202263336332P 2022-04-29 2022-04-29
US63/336,332 2022-04-29
US202263371454P 2022-08-15 2022-08-15
US63/371,454 2022-08-15
PCT/EP2023/061297 WO2023209177A1 (en) 2022-04-29 2023-04-28 Sars-cov-2 antibodies and methods of using the same

Publications (2)

Publication Number Publication Date
JP2025514858A true JP2025514858A (ja) 2025-05-09
JP2025514858A5 JP2025514858A5 (enExample) 2026-05-07

Family

ID=86424696

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024563287A Pending JP2025514858A (ja) 2022-04-29 2023-04-28 ＳＡＲＳ－ＣｏＶ－２抗体、及びその使用方法

Country Status (13)

Country Link
US (3) US20250289871A1 (enExample)
EP (1) EP4514842B1 (enExample)
JP (1) JP2025514858A (enExample)
KR (1) KR20250006253A (enExample)
CN (1) CN119836433A (enExample)
AU (1) AU2023262192A1 (enExample)
CA (1) CA3256096A1 (enExample)
CL (2) CL2024003259A1 (enExample)
CO (1) CO2024015983A2 (enExample)
CR (1) CR20240528A (enExample)
IL (1) IL316481A (enExample)
MX (1) MX2024013301A (enExample)
WO (1) WO2023209177A1 (enExample)

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Also Published As

Publication number Publication date
MX2024013301A (es) 2024-12-06
US12486316B1 (en) 2025-12-02
CL2025002547A1 (es) 2025-12-12
EP4514842A1 (en) 2025-03-05
US20260109754A1 (en) 2026-04-23
CN119836433A (zh) 2025-04-15
CA3256096A1 (en) 2023-11-02
CL2024003259A1 (es) 2025-03-14
CO2024015983A2 (es) 2025-03-06
EP4514842B1 (en) 2026-03-25
WO2023209177A1 (en) 2023-11-02
CR20240528A (es) 2025-04-04
KR20250006253A (ko) 2025-01-10
IL316481A (en) 2024-12-01
US20250289871A1 (en) 2025-09-18
AU2023262192A1 (en) 2024-12-05

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