CA3256096A1 - ANTIBODIES AGAINST SARS-CoV-2 AND THEIR METHODS OF USE - Google Patents

ANTIBODIES AGAINST SARS-CoV-2 AND THEIR METHODS OF USE

Info

Publication number
CA3256096A1
CA3256096A1 CA3256096A CA3256096A CA3256096A1 CA 3256096 A1 CA3256096 A1 CA 3256096A1 CA 3256096 A CA3256096 A CA 3256096A CA 3256096 A CA3256096 A CA 3256096A CA 3256096 A1 CA3256096 A1 CA 3256096A1
Authority
CA
Canada
Prior art keywords
antibody
antigen
binding fragment
seq
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3256096A
Other languages
English (en)
French (fr)
Inventor
Taylor COHEN
Joe Francica
Saravan RAJAN
Gilad Kaplan
YingYun CAI
Andrew DIPPEL
Original Assignee
AstraZeneca UK Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca UK Ltd filed Critical AstraZeneca UK Ltd
Publication of CA3256096A1 publication Critical patent/CA3256096A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/102—Coronaviridae (F)
    • C07K16/104—Severe acute respiratory syndrome coronavirus 2 [SARS‐CoV‐2]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56983—Viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/165—Coronaviridae, e.g. avian infectious bronchitis virus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Food Science & Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Peptides Or Proteins (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CA3256096A 2022-04-29 2023-04-28 ANTIBODIES AGAINST SARS-CoV-2 AND THEIR METHODS OF USE Pending CA3256096A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202263336332P 2022-04-29 2022-04-29
US63/336,332 2022-04-29
US202263371454P 2022-08-15 2022-08-15
US63/371,454 2022-08-15
PCT/EP2023/061297 WO2023209177A1 (en) 2022-04-29 2023-04-28 Sars-cov-2 antibodies and methods of using the same

Publications (1)

Publication Number Publication Date
CA3256096A1 true CA3256096A1 (en) 2023-11-02

Family

ID=86424696

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3256096A Pending CA3256096A1 (en) 2022-04-29 2023-04-28 ANTIBODIES AGAINST SARS-CoV-2 AND THEIR METHODS OF USE

Country Status (13)

Country Link
US (3) US20250289871A1 (enExample)
EP (1) EP4514842B1 (enExample)
JP (1) JP2025514858A (enExample)
KR (1) KR20250006253A (enExample)
CN (1) CN119836433A (enExample)
AU (1) AU2023262192A1 (enExample)
CA (1) CA3256096A1 (enExample)
CL (2) CL2024003259A1 (enExample)
CO (1) CO2024015983A2 (enExample)
CR (1) CR20240528A (enExample)
IL (1) IL316481A (enExample)
MX (1) MX2024013301A (enExample)
WO (1) WO2023209177A1 (enExample)

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Also Published As

Publication number Publication date
MX2024013301A (es) 2024-12-06
US12486316B1 (en) 2025-12-02
CL2025002547A1 (es) 2025-12-12
EP4514842A1 (en) 2025-03-05
US20260109754A1 (en) 2026-04-23
CN119836433A (zh) 2025-04-15
CL2024003259A1 (es) 2025-03-14
CO2024015983A2 (es) 2025-03-06
EP4514842B1 (en) 2026-03-25
WO2023209177A1 (en) 2023-11-02
JP2025514858A (ja) 2025-05-09
CR20240528A (es) 2025-04-04
KR20250006253A (ko) 2025-01-10
IL316481A (en) 2024-12-01
US20250289871A1 (en) 2025-09-18
AU2023262192A1 (en) 2024-12-05

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