JP2025513874A5 - - Google Patents
Info
- Publication number
- JP2025513874A5 JP2025513874A5 JP2024560578A JP2024560578A JP2025513874A5 JP 2025513874 A5 JP2025513874 A5 JP 2025513874A5 JP 2024560578 A JP2024560578 A JP 2024560578A JP 2024560578 A JP2024560578 A JP 2024560578A JP 2025513874 A5 JP2025513874 A5 JP 2025513874A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- rna
- seq
- cap analog
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263331145P | 2022-04-14 | 2022-04-14 | |
| US63/331,145 | 2022-04-14 | ||
| PCT/US2023/065719 WO2023201294A1 (en) | 2022-04-14 | 2023-04-13 | Rna polymerase variants |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025513874A JP2025513874A (ja) | 2025-04-30 |
| JP2025513874A5 true JP2025513874A5 (enExample) | 2026-05-15 |
Family
ID=86329119
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024560578A Pending JP2025513874A (ja) | 2022-04-14 | 2023-04-13 | Ｒｎａポリメラーゼバリアント |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20250250551A1 (enExample) |
| EP (1) | EP4508201A1 (enExample) |
| JP (1) | JP2025513874A (enExample) |
| CN (1) | CN119317710A (enExample) |
| WO (1) | WO2023201294A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK3134131T3 (en) | 2014-04-23 | 2022-02-07 | Modernatx Inc | Nucleic acid vaccines |
| WO2017020026A1 (en) | 2015-07-30 | 2017-02-02 | Modernatx, Inc. | Concatemeric peptide epitopes rnas |
| CN108430456B (zh) | 2015-10-22 | 2022-01-18 | 摩登纳特斯有限公司 | 癌症疫苗 |
| MD3718565T2 (ro) | 2015-10-22 | 2022-09-30 | Modernatx Inc | Vaccinuri împotriva virusului respirator |
| JP6983455B2 (ja) | 2016-09-14 | 2021-12-17 | モデルナティーエックス， インコーポレイテッド | 高純度ｒｎａ組成物及びその調製のための方法 |
| CN110167587A (zh) | 2016-11-11 | 2019-08-23 | 摩登纳特斯有限公司 | 流感疫苗 |
| WO2018170270A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Varicella zoster virus (vzv) vaccine |
| CN111212905A (zh) | 2017-08-18 | 2020-05-29 | 摩登纳特斯有限公司 | Rna聚合酶变体 |
| WO2019148101A1 (en) | 2018-01-29 | 2019-08-01 | Modernatx, Inc. | Rsv rna vaccines |
| AU2019345067A1 (en) | 2018-09-19 | 2021-04-08 | Modernatx, Inc. | High-purity peg lipids and uses thereof |
| US12151029B2 (en) | 2018-09-19 | 2024-11-26 | Modernatx, Inc. | PEG lipids and uses thereof |
| CN113874502A (zh) | 2019-03-11 | 2021-12-31 | 摩登纳特斯有限公司 | 补料分批体外转录方法 |
| WO2022150717A1 (en) | 2021-01-11 | 2022-07-14 | Modernatx, Inc. | Seasonal rna influenza virus vaccines |
| US20220363937A1 (en) | 2021-05-14 | 2022-11-17 | Armstrong World Industries, Inc. | Stabilization of antimicrobial coatings |
| CN118373866A (zh) * | 2023-01-20 | 2024-07-23 | 深圳瑞吉生物科技有限公司 | 一种用于核酸的5’端加帽的化合物及其应用 |
| US20250270523A1 (en) * | 2023-03-01 | 2025-08-28 | Nanjing Vazyme Biotech Co., Ltd. | Rna polymerase variant, and preparation method therefor and use thereof in rna synthesis |
| CN120060188A (zh) * | 2023-11-29 | 2025-05-30 | 武汉核圣生物技术有限公司 | T7-rna聚合酶突变体及其应用 |
| WO2025152833A1 (zh) * | 2024-01-19 | 2025-07-24 | 南京诺唯赞生物科技股份有限公司 | Rna聚合酶变体及其应用 |
| CN120775820A (zh) * | 2024-04-07 | 2025-10-14 | 南京诺唯赞生物科技股份有限公司 | Rna聚合酶变体 |
| CN118389495B (zh) * | 2024-06-24 | 2024-10-01 | 北京悦康科创医药科技股份有限公司 | 一种核糖修饰的加帽类似物及其应用 |
| EP4650358A3 (en) | 2024-04-26 | 2026-01-14 | Beijing Youcare Kechuang Pharmaceutical Technology Co., Ltd. | Ribose-modified cap analog and use thereof |
| WO2026089040A1 (ja) * | 2024-10-25 | 2026-04-30 | タカラバイオ株式会社 | Ｒｎａポリメラーゼ変異体 |
| CN120330158B (zh) * | 2025-06-19 | 2025-09-12 | 南京诺唯赞生物科技股份有限公司 | Rna聚合酶变体及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL215513B1 (pl) | 2008-06-06 | 2013-12-31 | Univ Warszawski | Nowe boranofosforanowe analogi dinukleotydów, ich zastosowanie, czasteczka RNA, sposób otrzymywania RNA oraz sposób otrzymywania peptydów lub bialka |
| EP2377938A1 (en) * | 2010-04-16 | 2011-10-19 | Eukarys | Capping-prone RNA polymerase enzymes and their applications |
| WO2017066797A1 (en) | 2015-10-16 | 2017-04-20 | Modernatx, Inc. | Trinucleotide mrna cap analogs |
| JP2022521094A (ja) * | 2019-02-20 | 2022-04-05 | モデルナティエックス インコーポレイテッド | 共転写キャッピング用ｒｎａポリメラーゼバリアント |
-
2023
- 2023-04-13 WO PCT/US2023/065719 patent/WO2023201294A1/en not_active Ceased
- 2023-04-13 CN CN202380039861.8A patent/CN119317710A/zh active Pending
- 2023-04-13 JP JP2024560578A patent/JP2025513874A/ja active Pending
- 2023-04-13 US US18/856,588 patent/US20250250551A1/en active Pending
- 2023-04-13 EP EP23722246.8A patent/EP4508201A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2022521094A5 (enExample) | ||
| AU2023229522B2 (en) | Compositions and methods for synthesizing 5'-Capped RNAs | |
| JP7129343B2 (ja) | 正確な分子バーコーディング | |
| US9422603B2 (en) | Analyzing messenger RNA and micro RNA in the same reaction mixture | |
| JP3085409B2 (ja) | 標的核酸配列の検出方法およびそのための試薬キット | |
| CA2734514C (en) | Self-avoiding molecular recognition systems in dna amplification | |
| US20150086981A1 (en) | Nucleoside-triphosphate conjugate and methods for the use thereof | |
| KR20210142636A (ko) | 공동-전사 캡핑을 위한 rna 폴리머라제 변이체 | |
| JP2005536193A (ja) | 少量のポリヌクレオチドを濃縮する方法 | |
| US9970048B2 (en) | Oligonucleotides and methods for the preparation of RNA libraries | |
| JP2012157369A (ja) | ２’−ニトロベンジル改変型リボヌクレオチド | |
| BRPI0609031A2 (pt) | métodos para a sìntese de uma molécula de ácido nucleico, para seletivamente amplificar uma seqüência de ácido nucleico alvo de um dna ou de uma mistura de ácidos nucleicos, para amplificar duas ou mais seqüências de nucleotìdeos alvo simultaneamente, para seqüenciar uma molécula de ácido nucleico alvo, para detectar uma molécula de ácido nucleico com diversidade genética, para detectar uma seqüência de nucleotìdeos alvo em uma amostra da ácido nucléico, e para permitir que uma especifidade anelar de um oligonucleotìdeo seja dualmente determinada por meio de uma estrutura do oligonucleotìdeo, e, oligonucleotìdeo de especifidade dual | |
| CA3191516C (en) | Advanced dumbbell pcr for isomir detection | |
| ES2953918T3 (es) | Método para amplificar ARNm y para preparar bibliotecas de ARNm de longitud completa | |
| KR100860619B1 (ko) | 성인성 질환 유발 병원체 핵산 검출용올리고뉴클레오타이드 | |
| WO2007058499A1 (en) | Oligonucleotides for detecting respiratory virus nucleic acids | |
| WO2004092330A2 (en) | Method of generating long nucleic acid molecules of defined sequence | |
| JP2020065488A (ja) | 重症熱性血小板減少症候群（ｓｆｔｓ）ウイルス検出用プライマーセット | |
| JP4942160B2 (ja) | ＲｅｃＡタンパク質を利用した核酸の等温増幅法 | |
| JP2005013173A5 (enExample) | ||
| CN102597264A (zh) | Rna指数式扩增的方法以及rna反应器 | |
| WO2011034895A1 (en) | Compositions, methods and uses for nucleotide analogues | |
| JPWO2020027096A1 (ja) | プライマー及びその使用 | |
| JP2006271250A (ja) | 塩基配列決定方法 | |
| WO2019150564A1 (ja) | スルホンアミド骨格をもつオリゴヌクレオチドを鋳型として用いたｄｎａ複製法 |