JP2025512340A - 樹状分子、その調製のためのプロセスおよびその使用 - Google Patents

樹状分子、その調製のためのプロセスおよびその使用 Download PDF

Info

Publication number
JP2025512340A
JP2025512340A JP2024559719A JP2024559719A JP2025512340A JP 2025512340 A JP2025512340 A JP 2025512340A JP 2024559719 A JP2024559719 A JP 2024559719A JP 2024559719 A JP2024559719 A JP 2024559719A JP 2025512340 A JP2025512340 A JP 2025512340A
Authority
JP
Japan
Prior art keywords
formula
compound
group
mmol
equiv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024559719A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025512340A5 (https=
Inventor
デルフィーン フェルダー‐フレッシュ,
ベンジャミン アイェラ,
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Superbranche
Original Assignee
Superbranche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Superbranche filed Critical Superbranche
Publication of JP2025512340A publication Critical patent/JP2025512340A/ja
Publication of JP2025512340A5 publication Critical patent/JP2025512340A5/ja
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08GMACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G83/00Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
    • C08G83/002Dendritic macromolecules
    • C08G83/003Dendrimers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4056Esters of arylalkanephosphonic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0002General or multifunctional contrast agents, e.g. chelated agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/52Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/28Phosphorus compounds with one or more P—C bonds
    • C07F9/38Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40Esters thereof
    • C07F9/4003Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025Esters of poly(thio)phosphonic acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
JP2024559719A 2022-04-14 2023-04-13 樹状分子、その調製のためのプロセスおよびその使用 Pending JP2025512340A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP22305547.6 2022-04-14
EP22305547.6A EP4261244A1 (en) 2022-04-14 2022-04-14 Dendritic molecules, process for their preparation and uses thereof
PCT/EP2023/059630 WO2023198813A1 (en) 2022-04-14 2023-04-13 Dendritic molecules, process for their preparation and uses thereof

Publications (2)

Publication Number Publication Date
JP2025512340A true JP2025512340A (ja) 2025-04-17
JP2025512340A5 JP2025512340A5 (https=) 2026-04-21

Family

ID=81851615

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024559719A Pending JP2025512340A (ja) 2022-04-14 2023-04-13 樹状分子、その調製のためのプロセスおよびその使用

Country Status (12)

Country Link
US (1) US20250376485A1 (https=)
EP (2) EP4261244A1 (https=)
JP (1) JP2025512340A (https=)
CN (1) CN119013334A (https=)
AU (1) AU2023252505A1 (https=)
CA (1) CA3246924A1 (https=)
DK (1) DK4508118T3 (https=)
ES (1) ES3056645T3 (https=)
FI (1) FI4508118T3 (https=)
PL (1) PL4508118T3 (https=)
PT (1) PT4508118T (https=)
WO (1) WO2023198813A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN119841958B (zh) * 2024-07-31 2025-10-28 中国农业大学 一种广谱识别喹诺酮类药物的纳米抗体及其制备方法与应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015150502A1 (en) * 2014-04-01 2015-10-08 Centre National De La Recherche Scientifique Dendronized metallic oxide nanoparticles, a process for preparing the same and their uses

Also Published As

Publication number Publication date
EP4508118B1 (en) 2025-11-26
CA3246924A1 (en) 2023-10-19
ES3056645T3 (en) 2026-02-23
FI4508118T3 (fi) 2026-02-10
WO2023198813A1 (en) 2023-10-19
DK4508118T3 (da) 2026-02-23
EP4508118A1 (en) 2025-02-19
EP4261244A1 (en) 2023-10-18
AU2023252505A1 (en) 2024-09-12
US20250376485A1 (en) 2025-12-11
PT4508118T (pt) 2026-02-26
PL4508118T3 (pl) 2026-04-07
CN119013334A (zh) 2024-11-22

Similar Documents

Publication Publication Date Title
Fujita et al. Carboxylative cyclization of propargylic amines with CO2 catalyzed by dendritic N-heterocyclic carbene–gold (I) complexes
JP2025512340A (ja) 樹状分子、その調製のためのプロセスおよびその使用
CN101679463A (zh) 制备氧化磷脂的改进方法
EP3118244B1 (en) Novel cationic polyphosphazene compound, polyphosphazenes-drug conjugate compound and method for preparing same
Rengan et al. The synthesis of phosphonium cascade molecules
El Brahmi et al. Symmetrical and unsymmetrical incorporation of active biological monomers on the surface of phosphorus dendrimers
JP3985025B2 (ja) 両親媒性化合物、可溶性カーボンナノチューブ複合体
CN103709410B (zh) 酸敏感两亲性嵌段共聚物及其自组织胶束、用途
CN106905120A (zh) Y型多缩乙二醇衍生物及其制备方法
EP4260876A1 (en) Compositions of dispersed systems for biomedical applications, process for their preparation and uses thereof
CN110305301B (zh) 一种两亲性的树枝化含糖共聚物及其合成方法
RU2699071C1 (ru) Новый полиэтиленгликольсодержащий глицеролипид
JP5142279B2 (ja) 生体関連物質計測デバイス、人工臓器用表面修飾材料
CN103588752A (zh) 一种甲基丙烯酸原酸酯类新单体及其两亲性嵌段共聚物制备方法和应用
WO2015065168A1 (en) Oligo-ethylene glycol based phosphonate surface modification reagents and use thereof
JP6727643B2 (ja) 化合物、表面処理剤、及び表面処理方法
KR100413532B1 (ko) 폴리아민이 말단에 치환된 덴드리머 및 그 제조방법
Hu et al. Synthesis of Fan‐Shaped C3 Molecule with Three Glycyrrhetinic Acid Units and Self‐Assembly Properties
CN109134282B (zh) 一种树状多缩乙二醇衍生物及其制备方法和应用
WO2025022130A1 (en) Dendrimers comprising fluorescent dyes
CN120091992A (zh) 阳离子脂质及其制备方法
JP2014196271A (ja) 含フッ素リン酸エステル化合物およびその塩ならびに表面処理剤
Pasteur A Liquid-Crystalline [2] Catenane and Its Copper (I) Complex
CN118420894A (zh) 一种含氟四苯乙烯双亲化合物及其合成方法和应用
CN110357930A (zh) 一种单巯基双十六烷基醚聚乙二醇间链寡糖糖脂的合成方法

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20260411

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20260411