JP2025509233A - デアミダーゼ阻害剤及びデアミダーゼドメインを有する融合ポリペプチド - Google Patents

デアミダーゼ阻害剤及びデアミダーゼドメインを有する融合ポリペプチド Download PDF

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Publication number
JP2025509233A
JP2025509233A JP2024553171A JP2024553171A JP2025509233A JP 2025509233 A JP2025509233 A JP 2025509233A JP 2024553171 A JP2024553171 A JP 2024553171A JP 2024553171 A JP2024553171 A JP 2024553171A JP 2025509233 A JP2025509233 A JP 2025509233A
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JP
Japan
Prior art keywords
seq
polypeptide
amino acid
deamidase
acid sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024553171A
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English (en)
Japanese (ja)
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JP2025509233A5 (enExample
Inventor
マウヌス エクローフ イェンス
Original Assignee
ノボザイムス アクティーゼルスカブ
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Filing date
Publication date
Priority claimed from EP22160942.3A external-priority patent/EP4242303A1/en
Application filed by ノボザイムス アクティーゼルスカブ filed Critical ノボザイムス アクティーゼルスカブ
Publication of JP2025509233A publication Critical patent/JP2025509233A/ja
Publication of JP2025509233A5 publication Critical patent/JP2025509233A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C12N9/80—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5) acting on amide bonds in linear amides (3.5.1)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)
    • C12Y305/01044—Protein-glutamine glutaminase (3.5.1.44)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
    • C12Y305/01—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in linear amides (3.5.1)

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
JP2024553171A 2022-03-08 2023-03-08 デアミダーゼ阻害剤及びデアミダーゼドメインを有する融合ポリペプチド Pending JP2025509233A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP22160942.3 2022-03-08
EP22160942.3A EP4242303A1 (en) 2022-03-08 2022-03-08 Fusion polypeptides with deamidase inhibitor and deamidase domains
EP22183793 2022-07-08
EP22183793.3 2022-07-08
PCT/EP2023/055936 WO2023170177A1 (en) 2022-03-08 2023-03-08 Fusion polypeptides with deamidase inhibitor and deamidase domains

Publications (2)

Publication Number Publication Date
JP2025509233A true JP2025509233A (ja) 2025-04-11
JP2025509233A5 JP2025509233A5 (enExample) 2026-03-16

Family

ID=85477826

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024553171A Pending JP2025509233A (ja) 2022-03-08 2023-03-08 デアミダーゼ阻害剤及びデアミダーゼドメインを有する融合ポリペプチド

Country Status (6)

Country Link
US (1) US20250215412A1 (enExample)
EP (1) EP4490286A1 (enExample)
JP (1) JP2025509233A (enExample)
AU (1) AU2023231428A1 (enExample)
CA (1) CA3242405A1 (enExample)
WO (1) WO2023170177A1 (enExample)

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* Cited by examiner, † Cited by third party
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US20250188435A1 (en) * 2022-03-09 2025-06-12 Amano Enzyme Inc. Modified protein glutaminase
AU2024289271A1 (en) 2023-07-05 2025-11-27 Novozymes A/S Foamable dairy products
WO2025132872A1 (en) 2023-12-20 2025-06-26 Novozymes A/S Modified leguminous protein with improved colloidal stability
WO2025233391A1 (en) 2024-05-09 2025-11-13 Novozymes A/S Stabilized liquid deamidase compositions
WO2025233389A1 (en) 2024-05-09 2025-11-13 Novozymes A/S Stabilized liquid deamidase compositions
WO2026060197A1 (en) * 2024-09-13 2026-03-19 International N&H Denmark Aps Novel protein glutaminase for plant based beverages
WO2026073574A1 (en) 2024-10-01 2026-04-09 Novozymes A/S Codon optimized deamidase expression
WO2026076952A1 (en) 2024-10-08 2026-04-16 Novozymes A/S Processes for obtaining dairy protein-based ready-to-drink beverages

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GB1483591A (en) 1973-07-23 1977-08-24 Novo Industri As Process for coating water soluble or water dispersible particles by means of the fluid bed technique
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DK263584D0 (da) 1984-05-29 1984-05-29 Novo Industri As Enzymholdige granulater anvendt som detergentadditiver
US4713245A (en) 1984-06-04 1987-12-15 Mitsui Toatsu Chemicals, Incorporated Granule containing physiologically-active substance, method for preparing same and use thereof
EG18543A (en) 1986-02-20 1993-07-30 Albright & Wilson Protected enzyme systems
DK122686D0 (da) 1986-03-17 1986-03-17 Novo Industri As Fremstilling af proteiner
DK435587D0 (da) 1987-08-21 1987-08-21 Novo Industri As Fremgangsmaade til fremstilling af et enzymholdigt granulat
DK435687D0 (da) 1987-08-21 1987-08-21 Novo Industri As Enzymholdigt granulat og fremgangsmaade til fremstilling deraf
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
DK78189D0 (da) 1989-02-20 1989-02-20 Novo Industri As Enzymholdigt granulat og fremgangsmaade til fremstilling deraf
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WO2021049591A1 (ja) 2019-09-12 2021-03-18 天野エンザイム株式会社 植物タンパク質濃縮物の製造方法

Also Published As

Publication number Publication date
AU2023231428A1 (en) 2024-07-11
WO2023170177A1 (en) 2023-09-14
US20250215412A1 (en) 2025-07-03
CA3242405A1 (en) 2023-09-14
EP4490286A1 (en) 2025-01-15
WO2023170177A8 (en) 2023-11-09

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