JP2025508050A - Ｃｄ７０指向性がん免疫療法のための多重遺伝子編集細胞 - Google Patents

Ｃｄ７０指向性がん免疫療法のための多重遺伝子編集細胞 Download PDF

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JP2025508050A
JP2025508050A JP2024553353A JP2024553353A JP2025508050A JP 2025508050 A JP2025508050 A JP 2025508050A JP 2024553353 A JP2024553353 A JP 2024553353A JP 2024553353 A JP2024553353 A JP 2024553353A JP 2025508050 A JP2025508050 A JP 2025508050A
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sequence
amino acid
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JP2025508050A5 (https=
Inventor
エヌ コッホ，エリザベス
ウサディ，ジェイコブ
スリパックディヴォン，パリン
バーナビー トレイガー，ジェイムズ
チャン，アイバン
グオ，チャオ
ブーレン，ルシュアン グオ
ライダ リアナ ラゼティック，アレクサンドラ
ディクエアント，メアリー－リー
ウォルドナー，ハンスピーター
グオ，チャンガン
マシラマニー，チャンディラセガラン
シエ，ミンホン
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CRISPR Therapeutics AG
Nkarta Inc
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CRISPR Therapeutics AG
Nkarta Inc
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JP2024553353A 2022-03-07 2023-03-06 Ｃｄ７０指向性がん免疫療法のための多重遺伝子編集細胞 Pending JP2025508050A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263268967P 2022-03-07 2022-03-07
US63/268,967 2022-03-07
PCT/US2023/063795 WO2023172879A2 (en) 2022-03-07 2023-03-06 Multiplex gene edited cells for cd70-directed cancer immunotherapy

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JP2025508050A true JP2025508050A (ja) 2025-03-21
JP2025508050A5 JP2025508050A5 (https=) 2026-03-12

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US (1) US20230390392A1 (https=)
EP (1) EP4482872A4 (https=)
JP (1) JP2025508050A (https=)
AU (1) AU2023232083A1 (https=)
CA (1) CA3254363A1 (https=)
WO (1) WO2023172879A2 (https=)

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DK3143134T3 (da) 2014-05-15 2021-01-04 Nat Univ Singapore Modificerede, naturlige dræberceller og anvendelser deraf
BR112019019917A2 (pt) 2017-03-27 2020-04-22 Nat Univ Singapore receptores quiméricos nkg2d truncados e seus usos em imunoterapia de células exterminadoras naturais
EP3749685A4 (en) 2018-02-09 2021-12-22 National University of Singapore ACTIVATOR CHEMERIC RECEPTORS AND THEIR USES IN NATURAL KILLING CELL IMMUNOTHERAPY
JP7334985B2 (ja) 2018-04-02 2023-08-29 ナショナル ユニヴァーシティー オブ シンガポール 免疫細胞で発現される膜結合抗サイトカイン非シグナル伝達バインダーによるヒトサイトカインの中和
EP3844186A4 (en) 2018-08-29 2022-08-17 National University of Singapore METHOD OF SPECIFIC STIMULATION OF SURVIVAL AND EXPANSION OF GENETICALLY MODIFIED IMMUNE CELLS
EP3773918A4 (en) 2019-03-05 2022-01-05 Nkarta, Inc. CD19 DIRECTED CHIMERIC ANTIGEN RECEPTORS AND THEIR USES IN IMMUNOTHERAPY
AU2021286655A1 (en) 2020-06-12 2023-01-05 Nkarta, Inc. Genetically modified natural killer cells for CD70-directed cancer immunotherapy
CN117844811A (zh) * 2024-03-08 2024-04-09 上海恒润达生生物科技股份有限公司 靶向敲除CD70基因的sgRNA组合物及其应用

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US20030022311A1 (en) * 1996-05-21 2003-01-30 Dunnington Damien D. Human CIS protein
US20050271660A1 (en) * 2002-09-06 2005-12-08 Alexion Pharmaceuticals, Inc. Nebulization of monoclonal antibodies for treating pulmonary diseases
JP5122441B2 (ja) * 2005-04-19 2013-01-16 シアトル ジェネティックス， インコーポレイテッド ヒト化抗ｃｄ７０結合剤およびその使用
WO2015121454A1 (en) * 2014-02-14 2015-08-20 Cellectis Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
US11166985B2 (en) * 2017-05-12 2021-11-09 Crispr Therapeutics Ag Materials and methods for engineering cells and uses thereof in immuno-oncology
EP3707258A1 (en) * 2017-11-06 2020-09-16 Editas Medicine, Inc. Methods, compositions and components for crispr-cas9 editing of cblb in t cells for immunotherapy
EP3788369A1 (en) * 2018-05-01 2021-03-10 Novartis Ag Biomarkers for evaluating car-t cells to predict clinical outcome
MX2020012028A (es) * 2018-05-11 2021-03-29 Crispr Therapeutics Ag Metodos y composiciones para tratar el cancer.
WO2021095010A1 (en) * 2019-11-13 2021-05-20 Crispr Therapeutics Ag Renal cell carcinoma (rcc) therapy using genetically engineered t cells targeting cd70
JP2023502780A (ja) * 2019-11-25 2023-01-25 ケーエスキュー セラピューティクス， インコーポレイテッド 腫瘍浸潤リンパ球の活性化及び増殖方法
WO2021157601A1 (ja) * 2020-02-03 2021-08-12 国立大学法人東海国立大学機構 がんを有する対象においてがんを処置することに用いるための抗ｍｅｆｌｉｎ抗体、および当該抗体を含む医薬組成物
AU2021286655A1 (en) * 2020-06-12 2023-01-05 Nkarta, Inc. Genetically modified natural killer cells for CD70-directed cancer immunotherapy
KR20230041819A (ko) * 2020-07-29 2023-03-24 얀센 바이오테크 인코포레이티드 Hla-g 항원-결합 도메인을 포함하는 단백질 및 이의 용도

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US20230390392A1 (en) 2023-12-07
EP4482872A2 (en) 2025-01-01
WO2023172879A3 (en) 2023-11-16
CA3254363A1 (en) 2023-09-14
AU2023232083A1 (en) 2024-09-19
EP4482872A4 (en) 2026-03-18

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