JP2025507192A - アベルモスカスマニホット花のフラボノイド有効部位およびその調製方法並びに用途 - Google Patents

アベルモスカスマニホット花のフラボノイド有効部位およびその調製方法並びに用途 Download PDF

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JP2025507192A
JP2025507192A JP2024554801A JP2024554801A JP2025507192A JP 2025507192 A JP2025507192 A JP 2025507192A JP 2024554801 A JP2024554801 A JP 2024554801A JP 2024554801 A JP2024554801 A JP 2024554801A JP 2025507192 A JP2025507192 A JP 2025507192A
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quercetin
extract
abelmoschus
manii
flower
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JP2025507192A5 (https=
Inventor
海涛 唐
丹丹 王
海涛 葛
殿広 王
小蘭 彭
慧 梁
富江 王
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蘇中薬業集団股▲ふん▼有限公司
江蘇蘇中薬業研究院有限公司
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Publication of JP2025507192A publication Critical patent/JP2025507192A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/42—Respiratory system, e.g. lungs, bronchi or lung cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/577—Malvaceae (Mallow family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Pulmonology (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Physiology (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
JP2024554801A 2022-03-15 2022-03-15 アベルモスカスマニホット花のフラボノイド有効部位およびその調製方法並びに用途 Pending JP2025507192A (ja)

Applications Claiming Priority (1)

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PCT/CN2022/080818 WO2023173268A1 (zh) 2022-03-15 2022-03-15 一种黄蜀葵花黄酮类有效部位及其制备方法与应用

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JP2025507192A true JP2025507192A (ja) 2025-03-13
JP2025507192A5 JP2025507192A5 (https=) 2026-04-08

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US (1) US20250195598A1 (https=)
EP (1) EP4494646A4 (https=)
JP (1) JP2025507192A (https=)
CN (1) CN118973595A (https=)
WO (1) WO2023173268A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025055910A1 (zh) * 2023-09-16 2025-03-20 苏中药业集团股份有限公司 一种药物组合物在制备骨质疏松药物中的应用
CN118894949B (zh) * 2024-09-30 2025-01-24 临沂大学 一种金花葵籽中多糖的提取、纯化方法及其应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1994337A (zh) * 2006-11-11 2007-07-11 周亚球 黄蜀葵花总黄酮提取物、其制备及应用
CN102319275A (zh) * 2011-09-15 2012-01-18 江苏苏中药业集团股份有限公司 黄蜀葵花提取物、制剂及其制备方法
CN108567802A (zh) * 2018-07-25 2018-09-25 江苏苏中药业集团股份有限公司 一种黄蜀葵花黄酮类有效部位及其制备方法与应用
CN111920836A (zh) * 2019-06-13 2020-11-13 江苏苏中药业集团股份有限公司 一种黄蜀葵花提取物在制备治疗纤维化药物中的应用
CN112870236A (zh) * 2019-11-29 2021-06-01 江苏苏中药业集团股份有限公司 一种黄蜀葵花黄酮类有效部位及其制备方法与应用
CN112972508A (zh) * 2020-04-16 2021-06-18 江苏苏中药业集团股份有限公司 黄蜀葵花提取物作为trpc离子通道抑制剂的用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107519220A (zh) * 2017-09-15 2017-12-29 江苏苏中药业集团股份有限公司 一种黄蜀葵花中黄酮类化合物的提取方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1994337A (zh) * 2006-11-11 2007-07-11 周亚球 黄蜀葵花总黄酮提取物、其制备及应用
CN102319275A (zh) * 2011-09-15 2012-01-18 江苏苏中药业集团股份有限公司 黄蜀葵花提取物、制剂及其制备方法
CN108567802A (zh) * 2018-07-25 2018-09-25 江苏苏中药业集团股份有限公司 一种黄蜀葵花黄酮类有效部位及其制备方法与应用
CN111920836A (zh) * 2019-06-13 2020-11-13 江苏苏中药业集团股份有限公司 一种黄蜀葵花提取物在制备治疗纤维化药物中的应用
CN112870236A (zh) * 2019-11-29 2021-06-01 江苏苏中药业集团股份有限公司 一种黄蜀葵花黄酮类有效部位及其制备方法与应用
CN112972508A (zh) * 2020-04-16 2021-06-18 江苏苏中药业集团股份有限公司 黄蜀葵花提取物作为trpc离子通道抑制剂的用途

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ZHONGGUO ZHONGXIYI JIEHE ZAZHI, vol. 40, no. 8, JPN7025003383, August 2020 (2020-08-01), pages 901 - 907, ISSN: 0005652510 *

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WO2023173268A1 (zh) 2023-09-21
US20250195598A1 (en) 2025-06-19
CN118973595A (zh) 2024-11-15
EP4494646A1 (en) 2025-01-22
EP4494646A4 (en) 2026-02-18

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