JP2025506098A5 - - Google Patents

Info

Publication number
JP2025506098A5
JP2025506098A5 JP2024543285A JP2024543285A JP2025506098A5 JP 2025506098 A5 JP2025506098 A5 JP 2025506098A5 JP 2024543285 A JP2024543285 A JP 2024543285A JP 2024543285 A JP2024543285 A JP 2024543285A JP 2025506098 A5 JP2025506098 A5 JP 2025506098A5
Authority
JP
Japan
Prior art keywords
larinepag
radiation
measured
pattern
xrpd
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2024543285A
Other languages
English (en)
Japanese (ja)
Other versions
JP2025506098A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2023/013032 external-priority patent/WO2023158634A1/en
Publication of JP2025506098A publication Critical patent/JP2025506098A/ja
Publication of JP2025506098A5 publication Critical patent/JP2025506098A5/ja
Pending legal-status Critical Current

Links

JP2024543285A 2022-02-15 2023-02-14 結晶質プロスタサイクリン(ip)受容体アゴニストおよびその使用 Pending JP2025506098A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263310469P 2022-02-15 2022-02-15
US63/310,469 2022-02-15
PCT/US2023/013032 WO2023158634A1 (en) 2022-02-15 2023-02-14 Crystalline prostacyclin (ip) receptor agonist and uses thereof

Publications (2)

Publication Number Publication Date
JP2025506098A JP2025506098A (ja) 2025-03-07
JP2025506098A5 true JP2025506098A5 (https=) 2026-02-20

Family

ID=87578956

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024543285A Pending JP2025506098A (ja) 2022-02-15 2023-02-14 結晶質プロスタサイクリン(ip)受容体アゴニストおよびその使用

Country Status (9)

Country Link
US (2) US12098116B2 (https=)
EP (1) EP4479374A1 (https=)
JP (1) JP2025506098A (https=)
KR (1) KR20240149924A (https=)
CN (1) CN118922402A (https=)
AU (1) AU2023222747A1 (https=)
CA (1) CA3248736A1 (https=)
IL (1) IL314717A (https=)
WO (1) WO2023158634A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023158634A1 (en) 2022-02-15 2023-08-24 United Therapeutics Corporation Crystalline prostacyclin (ip) receptor agonist and uses thereof
US20240139207A1 (en) 2022-10-31 2024-05-02 United Therapeutics Corporation Methods for treating pulmonary hypertension
US20250282716A1 (en) 2024-03-11 2025-09-11 United Therapeutics Corporation Methods of making ip-receptor agonists

Family Cites Families (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2945530A1 (de) 1979-11-10 1981-06-04 Chemische Werke Hüls AG, 4370 Marl Harnstoffe mit cyclischen substituenten, ihre herstellung und verwendung als herbizide
JPH03160438A (ja) 1989-11-20 1991-07-10 Konica Corp ハロゲン化銀カラー写真感光材料
EP0442448A3 (en) 1990-02-13 1992-08-12 Bristol-Myers Squibb Company Heterocyclic carboxylic acids and esters
CA2085844A1 (en) 1991-12-27 1993-06-28 Nobuyuki Hamanaka Fused benzeneoxyacetic acid derivatives
JPH06329598A (ja) 1993-05-19 1994-11-29 Daicel Chem Ind Ltd エステルの製造方法
DE4318889A1 (de) 1993-06-07 1994-12-08 Bayer Ag Verfahren zur Herstellung von organischen Carbamaten
TW282456B (https=) 1994-03-10 1996-08-01 Fujisawa Yakusin Kogyo Kk
JPH11269138A (ja) 1998-03-20 1999-10-05 Mitsubishi Paper Mills Ltd 有機塩基発生剤
US6335459B1 (en) 1998-12-23 2002-01-01 Syntex (U.S.A.) Llc Aryl carboxylic acid and aryl tetrazole derivatives as IP receptor modulators
EP1046631A1 (en) 1999-04-19 2000-10-25 Rolic AG Liquid crystalline compounds
GB9908934D0 (en) 1999-04-19 1999-06-16 Rolic Ag Liquid crystalline compounds
US20040048844A1 (en) 1999-10-20 2004-03-11 Bristol-Myers Squibb Pharma Company Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
KR100523119B1 (ko) 2000-03-16 2005-10-20 에프. 호프만-라 로슈 아게 Ip 길항제로서의 카복실산 유도체
WO2002055484A1 (en) 2001-01-12 2002-07-18 Takeda Chemical Industries, Ltd. Biaryl compound, process for producing the same, and agent
TWI316055B (https=) 2001-04-26 2009-10-21 Nippon Shinyaku Co Ltd
WO2003007888A2 (en) 2001-07-20 2003-01-30 Adipogenix, Inc. Fat accumulation-modulating compounds
CN101284773A (zh) 2001-08-09 2008-10-15 小野药品工业株式会社 羧酸衍生物及以它为活性成分的药剂
TW200307539A (en) 2002-02-01 2003-12-16 Bristol Myers Squibb Co Cycloalkyl inhibitors of potassium channel function
TWI293715B (en) 2002-10-10 2008-02-21 Sipix Imaging Inc A method for inducing or enhancing the threshold of an electrophoretic display, an electrophoretic fluid and an electrophoretic display
CN1735598A (zh) 2002-11-11 2006-02-15 拜耳医药保健股份公司 作为ip受体拮抗剂的苯基或杂芳基氨基烷烃衍生物
RU2351590C2 (ru) 2003-02-10 2009-04-10 Вертекс Фармасьютикалз Инкорпорейтед Способ получения диариламина
GB0317498D0 (en) 2003-07-25 2003-08-27 Pfizer Ltd Compounds
JP4339890B2 (ja) 2003-09-22 2009-10-07 エフ.ホフマン−ラ ロシュ アーゲー アミノアルキルアミド置換シクロヘキシル誘導体
JP4402413B2 (ja) 2003-09-29 2010-01-20 財団法人21あおもり産業総合支援センター U字型化合物およびこれを含む液晶組成物
DE102004006785A1 (de) 2004-02-11 2005-09-08 Mayr, Herbert, Prof. Dr. Verfahren zur CC-Bindungsknüpfung zwischen elektrophilen Substraten und TT-Verbindungen in neutralen bis basischen wässrigen oder alkoholischen Lösungsmitteln ohne den Einsatz einer Lewis- oder Protonensäure
JP2008510726A (ja) 2004-08-20 2008-04-10 エントレメッド インコーポレイテッド プロテイナーゼ活性化受容体アンタゴニストを含む組成物および方法
JP2006083085A (ja) 2004-09-15 2006-03-30 Kyowa Hakko Kogyo Co Ltd 二環性ピリミジン誘導体の製造法およびその合成中間体
JP4792731B2 (ja) 2004-11-12 2011-10-12 Dic株式会社 重合性液晶組成物及び当該組成物の硬化物
WO2007051255A1 (en) 2005-11-04 2007-05-10 The University Of Sydney Process for the preparation of compounds containing an azacyclic ring system
JP2007161867A (ja) 2005-12-14 2007-06-28 Toyo Ink Mfg Co Ltd インキ組成物
US20080075692A1 (en) 2006-05-09 2008-03-27 Perrine Susan P Methods for treating blood disorders
WO2009117095A1 (en) 2008-03-18 2009-09-24 Arena Pharmaceuticals, Inc. Modulators of the prostacyclin (pgi2) receptor useful for the treatment of disorders related thereto
US20110224262A1 (en) 2008-11-26 2011-09-15 Arena Pharmaceuticals, Inc. Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (pgi2) receptor useful for the treatment of disorders related thereto
ES2548882T3 (es) 2008-12-08 2015-10-21 Arena Pharmaceuticals, Inc. Moduladores del receptor de prostaciclina (PGl2) útiles para el tratamiento de trastornos relacionados con los mismos
WO2011037613A1 (en) 2009-09-23 2011-03-31 Arena Pharmaceuticals, Inc. Crystalline forms and processes for the preparation of pgi2 receptor agonists
US10537546B2 (en) 2014-10-23 2020-01-21 Arena Pharmaceuticals, Inc. Method of treating conditions related to the PGI2 receptor
US12377067B2 (en) 2016-11-10 2025-08-05 Arena Pharmaceuticals, Inc. Methods of treating PAH with combinations of ralinepag and other agents
IL268997B2 (en) 2017-03-01 2023-09-01 Arena Pharm Inc Preparations containing pgi2 receptor agonists and processes for their preparation
CA3072079A1 (en) 2017-08-07 2019-02-14 Arena Pharmaceuticals, Inc. Methods of treatment
EP3796902A1 (en) 2018-05-16 2021-03-31 Arena Pharmaceuticals, Inc. Compositions comprising pgi2-receptor agonists and processes for the preparation thereof
WO2020048299A1 (zh) 2018-09-06 2020-03-12 广东东阳光药业有限公司 药物共晶体及其制备方法
WO2023158634A1 (en) 2022-02-15 2023-08-24 United Therapeutics Corporation Crystalline prostacyclin (ip) receptor agonist and uses thereof
AU2023236147A1 (en) 2022-03-17 2024-09-19 United Therapeutics Corporation Ralinepag prodrugs and uses thereof

Similar Documents

Publication Publication Date Title
JP2025506098A5 (https=)
KR102150383B1 (ko) 안지오텐신 ii 수용체 길항제 대사물질과 nep 억제제의 화합물, 및 이의 제조 방법
RU2735547C2 (ru) Фармацевтическая композиция, содержащая 2-{ 4-[n-(5,6-дифенилпиразин-2-ил)-n-изопропиламино]бутилокси} -n-(метилсульфонил)ацетамид
CA2687924A1 (en) Polymorphic forms of 3-(4-amino-1-oxo-1,3 dihydro-isoindol-2-yl)-piperidine-2,6-dione
JP2025511847A5 (https=)
JP2009534373A5 (https=)
JP2023550428A5 (https=)
JP2019509268A5 (https=)
HRP20171511T1 (hr) Ivabradin-hidroklorid, oblik iv
JP2024504392A5 (https=)
US9504672B2 (en) Compositions and methods for treating or preventing pneumovirus infection and associated diseases
CN107661302A (zh) 一种口服固体制剂及其应用
JPH0681723B2 (ja) 非−白金抗癌薬によりひき起こされる嘔吐の軽減用治療剤
JPS6081156A (ja) 去痰活性を有する新規な化合物,この製法及びこれを用いた薬物組成物
JP2005529084A5 (https=)
JP2024542840A5 (https=)
WO2020238885A1 (zh) 血管紧张素ii受体拮抗剂代谢产物与nep抑制剂的复合物的治疗方法
WO2009089702A1 (en) Stable 6-methoxy-2',3'-dideoxyguanosine, method for preparing the same and pharmaceutical composition containing the same
JP2024506942A5 (https=)
RU2018135072A (ru) Кристаллическая (2s,4r)-5-(5'-хлор-2'-фтор-[1,1'-бифенил]-4-ил)-2-(этоксиметил)-4-(3-гидроксиизоксазол-5-карбоксамидо)-2-метилпентановая кислота и ее применения
JP2019509286A5 (https=)
JP2025511126A5 (https=)
JP7751354B1 (ja) 結晶の製造方法
JP7709812B1 (ja) 固形組成物
JPS5970611A (ja) 医薬組成物