JP2025505645A5 - - Google Patents
Info
- Publication number
- JP2025505645A5 JP2025505645A5 JP2024546423A JP2024546423A JP2025505645A5 JP 2025505645 A5 JP2025505645 A5 JP 2025505645A5 JP 2024546423 A JP2024546423 A JP 2024546423A JP 2024546423 A JP2024546423 A JP 2024546423A JP 2025505645 A5 JP2025505645 A5 JP 2025505645A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- groups
- substituted
- optionally substituted
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263307926P | 2022-02-08 | 2022-02-08 | |
| US63/307,926 | 2022-02-08 | ||
| PCT/US2023/012583 WO2023154314A1 (en) | 2022-02-08 | 2023-02-08 | Spiro piperidine derivatives as inhibitors of apol1 and methods of using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025505645A JP2025505645A (ja) | 2025-02-28 |
| JP2025505645A5 true JP2025505645A5 (https=) | 2026-02-04 |
Family
ID=85415293
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024546423A Pending JP2025505645A (ja) | 2022-02-08 | 2023-02-08 | Ａｐｏｌ１の阻害剤としてのスピロピペリジン誘導体およびその使用方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20250195483A1 (https=) |
| EP (1) | EP4476207A1 (https=) |
| JP (1) | JP2025505645A (https=) |
| CN (1) | CN119212986A (https=) |
| AU (1) | AU2023218940A1 (https=) |
| CA (1) | CA3251155A1 (https=) |
| CO (1) | CO2024012060A2 (https=) |
| WO (1) | WO2023154314A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11618746B2 (en) | 2018-12-17 | 2023-04-04 | Vertex Pharmaceuticals Incorporated | Inhibitors of APOL1 and methods of using same |
| WO2021154997A1 (en) | 2020-01-29 | 2021-08-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of apol1 and methods of using same |
| CN115867543A (zh) | 2020-06-12 | 2023-03-28 | 弗特克斯药品有限公司 | Apol1抑制剂的固体形式及其使用方法 |
| CA3185604A1 (en) | 2020-06-12 | 2021-12-16 | Vertex Pharmaceuticals Incorporated | Inhibitors of apol1 and use of the same |
| CN116547287B (zh) | 2020-08-26 | 2025-09-26 | 弗特克斯药品有限公司 | Apol1的抑制剂及其使用方法 |
| US12612379B2 (en) | 2021-11-30 | 2026-04-28 | Vertex Pharmaceuticals Incorporated | Inhibitors of APOL1 and methods of using same |
| MX2024008868A (es) * | 2022-01-18 | 2024-09-23 | Maze Therapeutics Inc | Inhibidores de la apolipoproteína l1 (apol1) y métodos de uso. |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8222288B2 (en) * | 2006-08-30 | 2012-07-17 | The Regents Of The University Of Michigan | Small molecule inhibitors of MDM2 and the uses thereof |
| BRPI0721138A2 (pt) * | 2006-12-22 | 2014-04-01 | Hoffmann La Roche | Derivados de espiro-piperidina |
| JP2017535545A (ja) * | 2014-11-21 | 2017-11-30 | ラボラトリオス・デル・デエレ・エステベ・エセ・ア | 疼痛に対する多様な活性を有するスピロ−イソキノリン−１，４’−ピペリジン化合物 |
| WO2017137334A1 (en) * | 2016-02-08 | 2017-08-17 | F. Hoffmann-La Roche Ag | Spiroindolinones as ddr1 inhibitors |
| TW202136219A (zh) * | 2019-12-19 | 2021-10-01 | 美商卡司馬療法公司 | Trpml調節劑 |
| CN115867532A (zh) * | 2020-06-12 | 2023-03-28 | 弗特克斯药品有限公司 | Apol1的抑制剂及其用途 |
-
2023
- 2023-02-08 CN CN202380030501.1A patent/CN119212986A/zh active Pending
- 2023-02-08 WO PCT/US2023/012583 patent/WO2023154314A1/en not_active Ceased
- 2023-02-08 AU AU2023218940A patent/AU2023218940A1/en active Pending
- 2023-02-08 EP EP23708332.4A patent/EP4476207A1/en active Pending
- 2023-02-08 CA CA3251155A patent/CA3251155A1/en active Pending
- 2023-02-08 US US18/836,681 patent/US20250195483A1/en active Pending
- 2023-02-08 JP JP2024546423A patent/JP2025505645A/ja active Pending
-
2024
- 2024-09-04 CO CONC2024/0012060A patent/CO2024012060A2/es unknown
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