JP2025503637A - 治療用抗ｉｇｆ－１ｒ抗体をコードする核酸の送達のためのベクター構築物およびそれを使用する方法 - Google Patents

治療用抗ｉｇｆ－１ｒ抗体をコードする核酸の送達のためのベクター構築物およびそれを使用する方法 Download PDF

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JP2025503637A
JP2025503637A JP2024541135A JP2024541135A JP2025503637A JP 2025503637 A JP2025503637 A JP 2025503637A JP 2024541135 A JP2024541135 A JP 2024541135A JP 2024541135 A JP2024541135 A JP 2024541135A JP 2025503637 A JP2025503637 A JP 2025503637A
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nucleic acid
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acid sequence
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ミシェル ストーン，
テレサ ヒー，
ナチケタ グプタ，
ウェイラン シェン，
ダイアナ セペダ，
ルース カステラノス，
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クリヤ セラピューティクス， インコーポレイテッド
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JP2024541135A 2022-01-09 2023-01-09 治療用抗ｉｇｆ－１ｒ抗体をコードする核酸の送達のためのベクター構築物およびそれを使用する方法 Pending JP2025503637A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202263297787P 2022-01-09 2022-01-09
US63/297,787 2022-01-09
US202263374878P 2022-09-07 2022-09-07
US63/374,878 2022-09-07
PCT/US2023/060329 WO2023133561A1 (en) 2022-01-09 2023-01-09 Vector constructs for delivery of nucleic acids encoding therapeutic anti-igf-1r antibodies and methods of using the same

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JP2025503637A true JP2025503637A (ja) 2025-02-04
JP2025503637A5 JP2025503637A5 (https=) 2026-01-14

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US (1) US20250084434A1 (https=)
EP (1) EP4460522A1 (https=)
JP (1) JP2025503637A (https=)
KR (1) KR20240130139A (https=)
AU (1) AU2023205804A1 (https=)
CA (1) CA3247783A1 (https=)
CO (1) CO2024010847A2 (https=)
IL (1) IL314154A (https=)
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Publication number Priority date Publication date Assignee Title
US20220267450A1 (en) 2020-10-14 2022-08-25 Viridian Therapeutics, Inc. Compositions and methods for treatment of thyroid eye disease
EP4384219A4 (en) 2021-08-10 2025-06-18 Viridian Therapeutics, Inc. COMPOSITIONS, DOSAGES AND METHODS FOR THE TREATMENT OF THYROID EYE DISEASE
KR20260051103A (ko) 2023-07-07 2026-04-15 크리야 테라퓨틱스, 인크. 안과 병리상태를 치료하기 위한 aav 벡터의 안구주위 전달
WO2025039622A1 (zh) * 2023-08-23 2025-02-27 上海金珂博生物技术有限公司 经修饰的腺相关病毒载体及其在治疗中枢神经系统疾病中的用途
TW202519262A (zh) * 2023-09-06 2025-05-16 美商維里迪恩醫療股份有限公司 抗ｉｇｆ－１ｒ抗體之醫藥組合物

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US4861719A (en) 1986-04-25 1989-08-29 Fred Hutchinson Cancer Research Center DNA constructs for retrovirus packaging cell lines
US5356806A (en) 1987-06-05 1994-10-18 The United States Of America As Represented By The Department Of Health And Human Services Immortalized human cell lines containing exogenous cytochrome P450
US4937190A (en) 1987-10-15 1990-06-26 Wisconsin Alumni Research Foundation Translation enhancer
US6174666B1 (en) 1992-03-27 2001-01-16 The United States Of America As Represented By The Department Of Health And Human Services Method of eliminating inhibitory/instability regions from mRNA
US6204059B1 (en) 1994-06-30 2001-03-20 University Of Pittsburgh AAV capsid vehicles for molecular transfer
US5892071A (en) 1994-09-30 1999-04-06 The Reagents Of The University Of California Cationic transport reagents
US5527928A (en) 1994-09-30 1996-06-18 Nantz; Michael H. Cationic transport reagents
US5869715A (en) 1995-09-27 1999-02-09 The Reagents Of The University Of California Polyfunctional cationic cytofectins
EP1390490B1 (en) 2001-05-24 2009-04-15 Genzyme Corporation Muscle-specific expression vectors
EP1506286B1 (en) * 2002-05-24 2014-03-19 Merck Sharp & Dohme Corp. Neutralizing human anti-igfr antibody
AR046071A1 (es) 2003-07-10 2005-11-23 Hoffmann La Roche Anticuerpos contra el receptor i del factor de crecimiento de tipo insulinico y los usos de los mismos
EP2018421B1 (en) 2006-04-28 2012-12-19 The Trustees of the University of Pennsylvania Scalable production method for aav
JP2012515556A (ja) 2009-01-23 2012-07-12 バイオジェン・アイデック・エムエイ・インコーポレイテッド 低下したエフェクタ機能を有する安定化Ｆｃポリペプチドおよび使用方法
WO2020206098A1 (en) * 2019-04-03 2020-10-08 Regenxbio Inc. Gene therapy for eye pathologies

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US20250084434A1 (en) 2025-03-13
CA3247783A1 (en) 2023-07-13
EP4460522A1 (en) 2024-11-13
CO2024010847A2 (es) 2024-10-31
KR20240130139A (ko) 2024-08-28
MX2024008509A (es) 2024-07-19
IL314154A (en) 2024-09-01
AU2023205804A1 (en) 2024-07-25

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