JP2025503385A5 - - Google Patents
Info
- Publication number
- JP2025503385A5 JP2025503385A5 JP2024533005A JP2024533005A JP2025503385A5 JP 2025503385 A5 JP2025503385 A5 JP 2025503385A5 JP 2024533005 A JP2024533005 A JP 2024533005A JP 2024533005 A JP2024533005 A JP 2024533005A JP 2025503385 A5 JP2025503385 A5 JP 2025503385A5
- Authority
- JP
- Japan
- Prior art keywords
- inhibitor
- menin
- menin inhibitor
- moz
- tki
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163289943P | 2021-12-15 | 2021-12-15 | |
| US63/289,943 | 2021-12-15 | ||
| PCT/US2022/081587 WO2023114867A2 (en) | 2021-12-15 | 2022-12-14 | Therapeutic targeting of gastrointestinal stromal tumor (gist) by disrupting the menin-mll epigenetic complex |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2025503385A JP2025503385A (ja) | 2025-02-04 |
| JP2025503385A5 true JP2025503385A5 (https=) | 2025-12-22 |
Family
ID=86773651
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024533005A Pending JP2025503385A (ja) | 2021-12-15 | 2022-12-14 | メニン－ｍｌｌエピジェネティック複合体を破壊することによる消化管間質腫瘍（ｇｉｓｔ）の治療的標的化 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20250041299A1 (https=) |
| EP (1) | EP4447972A4 (https=) |
| JP (1) | JP2025503385A (https=) |
| KR (1) | KR20240121720A (https=) |
| CN (1) | CN118234497A (https=) |
| AU (1) | AU2022410890A1 (https=) |
| CA (1) | CA3235383A1 (https=) |
| IL (1) | IL311862A (https=) |
| MX (1) | MX2024007201A (https=) |
| WO (1) | WO2023114867A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017214367A1 (en) | 2016-06-10 | 2017-12-14 | Vitae Pharmaceuticals, Inc. | Inhibitors of the menin-mll interaction |
| TW202525813A (zh) | 2019-12-19 | 2025-07-01 | 比利時商健生藥品公司 | 經取代之直鏈螺環接衍生物 |
| EP4132932A4 (en) | 2020-04-07 | 2024-04-17 | Syndax Pharmaceuticals, Inc. | COMBINATIONS OF MENIN INHIBITORS AND CYP3A4 INHIBITORS AND METHODS OF USE THEREOF |
| KR20250006833A (ko) | 2022-03-28 | 2025-01-13 | 아이소스테릭스, 인코포레이티드 | 라이신 아세틸 전이효소의 myst 계열의 억제제 |
| TW202517650A (zh) | 2023-07-17 | 2025-05-01 | 美商庫拉腫瘤技術股份有限公司 | 包含ｍｅｎｉｎ抑制劑之醫藥組合物 |
| IL325861A (en) | 2023-07-17 | 2026-03-01 | Kura Oncology Inc | Crystalline forms of menin inhibitor |
| WO2025082444A2 (en) * | 2023-10-20 | 2025-04-24 | Janssen Pharmaceutica Nv | (r) -n-ethyl-5-fluoro-n-isopropyl-2- ( (5- (2- (6- ( (2-methoxyethyl) (methyl) amino) -2-methylhexan-3-yl) -2, 6-diazaspiro [3.4] octan-6-yl) -1, 2, 4-triazin-6-yl) oxy) benzamide, formulations and dosage regimens thereof, for use in treating cancer |
| WO2025106862A1 (en) * | 2023-11-17 | 2025-05-22 | Kura Oncology, Inc. | Methods of treating kit positive cancers with a menin inhibitor |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1246593A1 (zh) * | 2015-06-04 | 2018-09-14 | Kura Oncology, Inc. | 用於抑制menin蛋白与mll蛋白的相互作用的方法及组合物 |
| PH12018501955B1 (en) * | 2016-03-16 | 2024-01-24 | Kura Oncology Inc | Bridged bicyclic inhibitors of menin-mll and methods of use |
| PL3429591T3 (pl) * | 2016-03-16 | 2023-07-17 | Kura Oncology, Inc. | Podstawione pochodne tieno[2,3-d]pirymidyny jako inhibitory meniny-mll i metody ich zastosowania |
| JP2022503792A (ja) * | 2018-09-26 | 2022-01-12 | クラ オンコロジー，インク． | メニン阻害剤を用いた血液悪性腫瘍の処置 |
-
2022
- 2022-12-14 CN CN202280073517.6A patent/CN118234497A/zh active Pending
- 2022-12-14 MX MX2024007201A patent/MX2024007201A/es unknown
- 2022-12-14 EP EP22908673.1A patent/EP4447972A4/en active Pending
- 2022-12-14 IL IL311862A patent/IL311862A/en unknown
- 2022-12-14 CA CA3235383A patent/CA3235383A1/en active Pending
- 2022-12-14 KR KR1020247016183A patent/KR20240121720A/ko active Pending
- 2022-12-14 WO PCT/US2022/081587 patent/WO2023114867A2/en not_active Ceased
- 2022-12-14 US US18/717,194 patent/US20250041299A1/en active Pending
- 2022-12-14 JP JP2024533005A patent/JP2025503385A/ja active Pending
- 2022-12-14 AU AU2022410890A patent/AU2022410890A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2025503385A5 (https=) | ||
| ES2900829T3 (es) | Terapia combinada para el tratamiento del cáncer | |
| US20160051525A1 (en) | Combination therapy for proliferative disorders | |
| US20080032989A1 (en) | Method of treating inflammatory diseases using tyroskine kinase inhibitors | |
| US20040063719A1 (en) | Combination therapy using antihypertensive agents and endothelin antagonists | |
| JP2014065696A5 (https=) | ||
| JP2022544234A5 (https=) | ||
| TWI762784B (zh) | Cdk4/6抑制劑與egfr抑制劑聯合在製備治療腫瘤疾病的藥物中的用途 | |
| EP4110326B1 (en) | Combination comprising alpelisib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid | |
| US11524009B2 (en) | Combination comprising at least one spliceosome modulator and at least one inhibitor chosen from BCL2 inhibitors, BCL2/BCLxL inhibitors, and BCLxL inhibitors and methods of use | |
| RU2010135831A (ru) | Способы, лекарственные формы и наборы для введения зипрасидона без пищи | |
| CN1282248A (zh) | 阳萎的联合治疗 | |
| EP4054579A1 (en) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors | |
| JP2016528240A (ja) | ドルテグラビル、エムトリシタビン及びテノホビルの医薬コンビネーションを有する医薬 | |
| CN118201615A (zh) | 喹唑啉酮化合物用于治疗癌症的新用途 | |
| WO2022106711A1 (en) | Combination comprising abemaciclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid | |
| KR20240112932A (ko) | 암 치료를 위한 cdk2 억제제 및 cdk4 억제제를 포함하는 방법 및 투여 섭생법 | |
| WO2021063332A1 (zh) | 一种ezh2抑制剂与cdk4/6抑制剂联合在制备治疗肿瘤药物中的用途 | |
| WO2018170447A1 (en) | Combination therapies for the treatment of breast cancer | |
| JP2023510426A (ja) | 癌を治療するための上皮細胞増殖因子受容体チロシンキナーゼ阻害剤 | |
| JP2025516647A (ja) | Ｌｓｄ１阻害薬を用いる悪性末梢神経鞘腫（ｍｐｎｓｔ）の治療法 | |
| Azanza et al. | Comparative pharmacology of tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia | |
| JPWO2005009444A1 (ja) | 医薬組成物 | |
| AU2004273605B2 (en) | Treatment of gastrointestinal stromal tumors with imatinib and midostaurin | |
| CN114430681A (zh) | 使用egfr和cdk4/6抑制剂的组合治疗egfr突变相关的癌症 |