JP2025503006A - 新規ベンズイミダゾールピリジン誘導体 - Google Patents
新規ベンズイミダゾールピリジン誘導体 Download PDFInfo
- Publication number
- JP2025503006A JP2025503006A JP2024542942A JP2024542942A JP2025503006A JP 2025503006 A JP2025503006 A JP 2025503006A JP 2024542942 A JP2024542942 A JP 2024542942A JP 2024542942 A JP2024542942 A JP 2024542942A JP 2025503006 A JP2025503006 A JP 2025503006A
- Authority
- JP
- Japan
- Prior art keywords
- amino
- methyl
- pyridine
- alkyl
- heterocycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP22152241 | 2022-01-19 | ||
| EP22152241.0 | 2022-01-19 | ||
| PCT/EP2023/051053 WO2023139084A1 (en) | 2022-01-19 | 2023-01-18 | New benzimidazole pyridine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2025503006A true JP2025503006A (ja) | 2025-01-30 |
| JPWO2023139084A5 JPWO2023139084A5 (https=) | 2026-01-23 |
| JP2025503006A5 JP2025503006A5 (https=) | 2026-01-23 |
Family
ID=79730348
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024542942A Pending JP2025503006A (ja) | 2022-01-19 | 2023-01-18 | 新規ベンズイミダゾールピリジン誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20240366581A1 (https=) |
| EP (1) | EP4466259A1 (https=) |
| JP (1) | JP2025503006A (https=) |
| CN (1) | CN118510764A (https=) |
| AR (1) | AR128280A1 (https=) |
| TW (1) | TW202342450A (https=) |
| WO (1) | WO2023139084A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4642773A1 (en) * | 2022-12-27 | 2025-11-05 | F. Hoffmann-La Roche AG | New benzimidazole derivatives |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8362023B2 (en) | 2011-01-19 | 2013-01-29 | Hoffmann-La Roche Inc. | Pyrazolo pyrimidines |
| SG11202004925QA (en) * | 2017-12-02 | 2020-06-29 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of diseases |
-
2023
- 2023-01-17 AR ARP230100104A patent/AR128280A1/es unknown
- 2023-01-18 TW TW112102300A patent/TW202342450A/zh unknown
- 2023-01-18 CN CN202380016494.XA patent/CN118510764A/zh active Pending
- 2023-01-18 JP JP2024542942A patent/JP2025503006A/ja active Pending
- 2023-01-18 WO PCT/EP2023/051053 patent/WO2023139084A1/en not_active Ceased
- 2023-01-18 EP EP23701303.2A patent/EP4466259A1/en active Pending
-
2024
- 2024-07-18 US US18/777,331 patent/US20240366581A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2023139084A1 (en) | 2023-07-27 |
| AR128280A1 (es) | 2024-04-10 |
| CN118510764A (zh) | 2024-08-16 |
| EP4466259A1 (en) | 2024-11-27 |
| US20240366581A1 (en) | 2024-11-07 |
| TW202342450A (zh) | 2023-11-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108024970B (zh) | 用作cdk抑制剂的经过取代的杂环衍生物 | |
| AU2011317855B2 (en) | Substituted 6-amino-nicotinamides as KCNQ2/3 modulators | |
| US20240316047A1 (en) | Inhibitors of rna helicase dhx9 and uses thereof | |
| KR102111570B1 (ko) | 신규 이미다조피리다진 화합물 및 그의 용도 | |
| CN107074812B (zh) | 取代的嘧啶化合物 | |
| CN110229142A (zh) | 细胞周期蛋白依赖性激酶7(cdk7)的抑制剂 | |
| AU2017208998A1 (en) | Bruton's tyrosine kinase inhibitors | |
| CN103228660A (zh) | Kat ii 抑制剂 | |
| US20250115607A1 (en) | Pyridine derivatives | |
| JP2025523524A (ja) | 関節リウマチの処置のためのＳＩＫモジュレーターとしてのイミダゾ［４，５－ｂ］ピリジンおよびピラゾロ［１，５－ａ］ピリミジン誘導体 | |
| JP2026500715A (ja) | 新規ベンズイミダゾール誘導体 | |
| JP2025503005A (ja) | 新規ベンズイミダゾールピリジン誘導体 | |
| US20240366581A1 (en) | Benzimidazole pyridine derivatives | |
| CN114206856A (zh) | 抗疟疾的六氢嘧啶类似物 | |
| TW202510868A (zh) | 新穎吡唑并吡啶衍生物 | |
| HK40113671A (zh) | 新颖苯并咪唑吡啶衍生物 | |
| CN121712757A (zh) | 苯并咪唑作为sik活性调节剂 | |
| JP2026500714A (ja) | Ｓｉｋモジュレーターとして有用なベンズイミダゾール誘導体 | |
| WO2024233554A1 (en) | Isoxazolidines as ripk1 inhibitors and use thereof | |
| HK40117627A (zh) | 咪唑并[4，5-c]吡啶衍生物作为sik调节剂用於类风湿性关节炎的治疗 | |
| CA3008653C (en) | Bruton's tyrosine kinase inhibitors | |
| WO2026046976A1 (en) | Pyrazolopyridine phosphate esters for modulating salt-inducible kinase (sik) | |
| HK40065957A (zh) | 用作cdk抑制剂的经过取代的杂环衍生物 | |
| HK40111206A (zh) | 新颖苯并咪唑吡啶衍生物 | |
| EA053073B1 (ru) | Новые пиридиновые производные бензимидазола |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20260115 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20260115 |