CN118510764A - 新颖苯并咪唑吡啶衍生物 - Google Patents

新颖苯并咪唑吡啶衍生物 Download PDF

Info

Publication number
CN118510764A
CN118510764A CN202380016494.XA CN202380016494A CN118510764A CN 118510764 A CN118510764 A CN 118510764A CN 202380016494 A CN202380016494 A CN 202380016494A CN 118510764 A CN118510764 A CN 118510764A
Authority
CN
China
Prior art keywords
amino
methyl
pyridine
alkyl
heterocycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202380016494.XA
Other languages
English (en)
Chinese (zh)
Inventor
K·格罗布克·泽宾登
W·哈普
L·克雷斯
K-C·T·卢克
S·G·米施克
P·普夫利格
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CN118510764A publication Critical patent/CN118510764A/zh
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN202380016494.XA 2022-01-19 2023-01-18 新颖苯并咪唑吡啶衍生物 Pending CN118510764A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP22152241 2022-01-19
EP22152241.0 2022-01-19
PCT/EP2023/051053 WO2023139084A1 (en) 2022-01-19 2023-01-18 New benzimidazole pyridine derivatives

Publications (1)

Publication Number Publication Date
CN118510764A true CN118510764A (zh) 2024-08-16

Family

ID=79730348

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202380016494.XA Pending CN118510764A (zh) 2022-01-19 2023-01-18 新颖苯并咪唑吡啶衍生物

Country Status (7)

Country Link
US (1) US20240366581A1 (https=)
EP (1) EP4466259A1 (https=)
JP (1) JP2025503006A (https=)
CN (1) CN118510764A (https=)
AR (1) AR128280A1 (https=)
TW (1) TW202342450A (https=)
WO (1) WO2023139084A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4642773A1 (en) * 2022-12-27 2025-11-05 F. Hoffmann-La Roche AG New benzimidazole derivatives

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8362023B2 (en) 2011-01-19 2013-01-29 Hoffmann-La Roche Inc. Pyrazolo pyrimidines
SG11202004925QA (en) * 2017-12-02 2020-06-29 Galapagos Nv Novel compounds and pharmaceutical compositions thereof for the treatment of diseases

Also Published As

Publication number Publication date
WO2023139084A1 (en) 2023-07-27
AR128280A1 (es) 2024-04-10
JP2025503006A (ja) 2025-01-30
EP4466259A1 (en) 2024-11-27
US20240366581A1 (en) 2024-11-07
TW202342450A (zh) 2023-11-01

Similar Documents

Publication Publication Date Title
CN107530329B (zh) 用作CDK抑制剂的吡唑并[1，5-a][1，3，5]三嗪和吡唑并[1，5-a]嘧啶衍生物
CN108024970B (zh) 用作cdk抑制剂的经过取代的杂环衍生物
CN109071546B (zh) 作为jak抑制剂的吡唑并[1,5-a]吡嗪-4-基衍生物
KR20220109401A (ko) Parp7 억제제로서의 피리다진온
AU2011317855B2 (en) Substituted 6-amino-nicotinamides as KCNQ2/3 modulators
CN110229142A (zh) 细胞周期蛋白依赖性激酶7(cdk7)的抑制剂
AU2006327876A1 (en) Pyrimidine derivatives
CN103228660A (zh) Kat ii 抑制剂
US20250115607A1 (en) Pyridine derivatives
WO2024003208A1 (en) Imidazo[4,5-b]pyridine and pyrazolo[1,5-a]pyrimidine derivatives as sik modulators for the treatment of rheumatoid arthritis
US20240383875A1 (en) Benzimidazole Pyridine Derivatives
CN120418238A (zh) 新颖苯并咪唑衍生物
US20240366581A1 (en) Benzimidazole pyridine derivatives
CN114206856A (zh) 抗疟疾的六氢嘧啶类似物
CN121693503A (zh) 新颖吡唑并吡啶衍生物
HK40113671A (zh) 新颖苯并咪唑吡啶衍生物
CN120641410A (zh) 可用作sik调节剂的苯并咪唑衍生物
CN121712757A (zh) 苯并咪唑作为sik活性调节剂
HK40117627A (zh) 咪唑并[4，5-c]吡啶衍生物作为sik调节剂用於类风湿性关节炎的治疗
WO2024233554A1 (en) Isoxazolidines as ripk1 inhibitors and use thereof
CN117430589A (zh) 2-氨基嘧啶类化合物或其盐及其制备方法和用途
HK40111206A (zh) 新颖苯并咪唑吡啶衍生物
HK40065957A (zh) 用作cdk抑制剂的经过取代的杂环衍生物
HK1255239B (zh) 用作cdk抑制剂的经过取代的杂环衍生物
HK1187612A (en) Kat ii inhibitors

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40113671

Country of ref document: HK