JP2025502346A - Ｖｅｇｆを調節する方法およびその使用 - Google Patents

Ｖｅｇｆを調節する方法およびその使用 Download PDF

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JP2025502346A
JP2025502346A JP2024542251A JP2024542251A JP2025502346A JP 2025502346 A JP2025502346 A JP 2025502346A JP 2024542251 A JP2024542251 A JP 2024542251A JP 2024542251 A JP2024542251 A JP 2024542251A JP 2025502346 A JP2025502346 A JP 2025502346A
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vegf
gene
dcas9
composition
dna
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JP2025502346A5 (https=
Inventor
ジョウ，チャンヤン
スン，イーディー
マオ，シャオシュアイ
ポン，ウェンボー
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Epigenic Therapeutics Inc
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Epigenic Therapeutics Inc
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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    • C12N15/09—Recombinant DNA-technology
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/14—Hydrolases (3)
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    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • C12N9/222—Clustered regularly interspaced short palindromic repeats [CRISPR]-associated [CAS] enzymes
    • C12N9/226—Class 2 CAS enzyme complex, e.g. single CAS protein
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
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JP2024542251A 2022-01-14 2023-01-10 Ｖｅｇｆを調節する方法およびその使用 Pending JP2025502346A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2022/071930 2022-01-14
CN2022071930 2022-01-14
PCT/CN2023/071521 WO2023134658A1 (en) 2022-01-14 2023-01-10 Method of modulating vegf and uses thereof

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JP2025502346A true JP2025502346A (ja) 2025-01-24
JP2025502346A5 JP2025502346A5 (https=) 2026-01-20

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JP2024542251A Pending JP2025502346A (ja) 2022-01-14 2023-01-10 Ｖｅｇｆを調節する方法およびその使用

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US (1) US20250066772A1 (https=)
EP (1) EP4463551A1 (https=)
JP (1) JP2025502346A (https=)
KR (1) KR20240133745A (https=)
CN (1) CN118525093A (https=)
AU (1) AU2023207727A1 (https=)
CA (1) CA3247727A1 (https=)
TW (1) TW202342743A (https=)
WO (1) WO2023134658A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2025507990A (ja) * 2022-03-04 2025-03-21 エピジェニック・セラピューティクス・インコーポレイテッド ゲノム編集の組成物及び方法
WO2025261475A1 (zh) * 2024-06-21 2025-12-26 益杰立科(上海)生物科技有限公司 靶向血管内皮生长因子的工程化基因转录阻抑工具及用途

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US7067317B2 (en) * 2000-12-07 2006-06-27 Sangamo Biosciences, Inc. Regulation of angiogenesis with zinc finger proteins
WO2021243105A1 (en) * 2020-05-28 2021-12-02 University Of Southern California Composition and method for treating retinal vascular disease with vegf gene disruption
CN111748583A (zh) * 2020-07-17 2020-10-09 池嘉栋 一种基于CRISPR/dCas9的诱导型DNA甲基化编辑系统

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EP4463551A1 (en) 2024-11-20
AU2023207727A1 (en) 2024-07-11
CA3247727A1 (en) 2023-07-20
KR20240133745A (ko) 2024-09-04
CN118525093A (zh) 2024-08-20
WO2023134658A1 (en) 2023-07-20
TW202342743A (zh) 2023-11-01
US20250066772A1 (en) 2025-02-27

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