JP2024546138A - トリプタミンプロドラッグ - Google Patents

トリプタミンプロドラッグ Download PDF

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Publication number
JP2024546138A
JP2024546138A JP2024535372A JP2024535372A JP2024546138A JP 2024546138 A JP2024546138 A JP 2024546138A JP 2024535372 A JP2024535372 A JP 2024535372A JP 2024535372 A JP2024535372 A JP 2024535372A JP 2024546138 A JP2024546138 A JP 2024546138A
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JP
Japan
Prior art keywords
alkyl
compound
branched
co2h
hydrogen
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Pending
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JP2024535372A
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English (en)
Japanese (ja)
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JP2024546138A5 (OSRAM
Inventor
ネイサン・ブライソン
Original Assignee
レユニオン ニューロサイエンス，インコーポレイテッド
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Application filed by レユニオン ニューロサイエンス，インコーポレイテッド filed Critical レユニオン ニューロサイエンス，インコーポレイテッド
Publication of JP2024546138A publication Critical patent/JP2024546138A/ja
Publication of JP2024546138A5 publication Critical patent/JP2024546138A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2024535372A 2021-12-14 2022-12-08 トリプタミンプロドラッグ Pending JP2024546138A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163289501P 2021-12-14 2021-12-14
US63/289,501 2021-12-14
PCT/CA2022/051797 WO2023108260A1 (en) 2021-12-14 2022-12-08 Tryptamine prodrugs

Publications (2)

Publication Number Publication Date
JP2024546138A true JP2024546138A (ja) 2024-12-17
JP2024546138A5 JP2024546138A5 (OSRAM) 2025-12-24

Family

ID=86775179

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024535372A Pending JP2024546138A (ja) 2021-12-14 2022-12-08 トリプタミンプロドラッグ

Country Status (6)

Country Link
US (1) US20250051278A1 (OSRAM)
EP (1) EP4448489A4 (OSRAM)
JP (1) JP2024546138A (OSRAM)
CN (1) CN118679146A (OSRAM)
CA (1) CA3240633A1 (OSRAM)
WO (1) WO2023108260A1 (OSRAM)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4486448A1 (en) 2022-03-04 2025-01-08 Reset Pharmaceuticals, Inc. Co-crystals or salts comprising psilocin
WO2025250900A1 (en) * 2024-05-30 2025-12-04 Caamtech, Inc. 4-hydroxy-n,n-diisopropyltryptaminium hydroglutarate
WO2026024591A1 (en) * 2024-07-22 2026-01-29 Reunion Neuroscience, Inc. Tryptamine prodrug solid forms

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL327334A (en) * 2020-02-04 2026-05-01 Mindset Pharma Inc Psilocin derivatives as serotonergic psychedelics for the treatment of central nervous system disorders
JP7702654B2 (ja) * 2020-06-30 2025-07-04 リユニオン・ニューロサイエンス、インコーポレイテッド トリプタミンプロドラッグ
MX2023006997A (es) * 2020-12-18 2023-08-29 Compass Pathfinder Ltd Alcaloides de indol modificados para usos terapeuticos.

Also Published As

Publication number Publication date
US20250051278A1 (en) 2025-02-13
WO2023108260A1 (en) 2023-06-22
EP4448489A1 (en) 2024-10-23
CN118679146A (zh) 2024-09-20
CA3240633A1 (en) 2023-06-22
EP4448489A4 (en) 2025-12-31

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