JP2024544012A5 - - Google Patents
Info
- Publication number
- JP2024544012A5 JP2024544012A5 JP2024533013A JP2024533013A JP2024544012A5 JP 2024544012 A5 JP2024544012 A5 JP 2024544012A5 JP 2024533013 A JP2024533013 A JP 2024533013A JP 2024533013 A JP2024533013 A JP 2024533013A JP 2024544012 A5 JP2024544012 A5 JP 2024544012A5
- Authority
- JP
- Japan
- Prior art keywords
- gag
- approximately
- protein
- fusion protein
- napdnabp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163285995P | 2021-12-03 | 2021-12-03 | |
| US63/285,995 | 2021-12-03 | ||
| US202263298621P | 2022-01-11 | 2022-01-11 | |
| US63/298,621 | 2022-01-11 | ||
| PCT/US2022/080834 WO2023102537A2 (en) | 2021-12-03 | 2022-12-02 | Self-assembling virus-like particles for delivery of nucleic acid programmable fusion proteins and methods of making and using same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024544012A JP2024544012A (ja) | 2024-11-26 |
| JP2024544012A5 true JP2024544012A5 (https=) | 2025-12-10 |
Family
ID=85158785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024533013A Pending JP2024544012A (ja) | 2021-12-03 | 2022-12-02 | 核酸プログラマブル融合タンパク質を送達するためのセルフアセンブルウイルス様粒子ならびにその作製方法および使用方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20250382334A1 (https=) |
| EP (1) | EP4441073A2 (https=) |
| JP (1) | JP2024544012A (https=) |
| KR (1) | KR20240112361A (https=) |
| AU (1) | AU2022400961A1 (https=) |
| CA (1) | CA3238778A1 (https=) |
| GB (1) | GB2630190A (https=) |
| IL (1) | IL312889A (https=) |
| WO (1) | WO2023102537A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9322037B2 (en) | 2013-09-06 | 2016-04-26 | President And Fellows Of Harvard College | Cas9-FokI fusion proteins and uses thereof |
| US9228207B2 (en) | 2013-09-06 | 2016-01-05 | President And Fellows Of Harvard College | Switchable gRNAs comprising aptamers |
| EP3592853A1 (en) | 2017-03-09 | 2020-01-15 | President and Fellows of Harvard College | Suppression of pain by gene editing |
| US12390514B2 (en) | 2017-03-09 | 2025-08-19 | President And Fellows Of Harvard College | Cancer vaccine |
| US12522807B2 (en) | 2018-07-09 | 2026-01-13 | The Broad Institute, Inc. | RNA programmable epigenetic RNA modifiers and uses thereof |
| WO2020191233A1 (en) | 2019-03-19 | 2020-09-24 | The Broad Institute, Inc. | Methods and compositions for editing nucleotide sequences |
| US12473543B2 (en) | 2019-04-17 | 2025-11-18 | The Broad Institute, Inc. | Adenine base editors with reduced off-target effects |
| WO2020252455A1 (en) | 2019-06-13 | 2020-12-17 | The General Hospital Corporation | Engineered human-endogenous virus-like particles and methods of use thereof for delivery to cells |
| CA3189601A1 (en) | 2020-07-24 | 2022-01-27 | The General Hospital Corporation | Enhanced virus-like particles and methods of use thereof for delivery to cells |
| WO2025051278A1 (en) * | 2023-09-09 | 2025-03-13 | Geneditbio Limited | Engineered protein delivery vehicle |
| WO2025096936A2 (en) | 2023-11-03 | 2025-05-08 | The Broad Institute, Inc. | Use of prime editing in correcting mutations in cdkl5 |
| WO2025137543A1 (en) * | 2023-12-22 | 2025-06-26 | President And Fellows Of Harvard College | Methods for screening for next generation nucleic acid delivery vectors |
| CN118126137A (zh) * | 2024-01-19 | 2024-06-04 | 微光基因(苏州)有限公司 | 用于递送核酸和蛋白质的类病毒样蛋白颗粒及其制备方法 |
| CN118086408A (zh) * | 2024-04-25 | 2024-05-28 | 华南理工大学 | 一种可实现靶向肌肉细胞基因编辑的仿病毒颗粒及其制备方法和应用 |
| WO2026024856A2 (en) | 2024-07-23 | 2026-01-29 | The Broad Institute, Inc. | Compositions and methods for production of double-stranded dna in cells for programmable gene integration |
| CN119162152B (zh) * | 2024-11-18 | 2025-02-25 | 南京农业大学三亚研究院 | 一种扩大编辑范围且提高编辑效率的高精准碱基编辑器 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4880635B1 (en) | 1984-08-08 | 1996-07-02 | Liposome Company | Dehydrated liposomes |
| US4921757A (en) | 1985-04-26 | 1990-05-01 | Massachusetts Institute Of Technology | System for delayed and pulsed release of biologically active substances |
| US4920016A (en) | 1986-12-24 | 1990-04-24 | Linear Technology, Inc. | Liposomes with enhanced circulation time |
| JPH0825869B2 (ja) | 1987-02-09 | 1996-03-13 | 株式会社ビタミン研究所 | 抗腫瘍剤包埋リポソ−ム製剤 |
| US4917951A (en) | 1987-07-28 | 1990-04-17 | Micro-Pak, Inc. | Lipid vesicles formed of surfactants and steroids |
| US4911928A (en) | 1987-03-13 | 1990-03-27 | Micro-Pak, Inc. | Paucilamellar lipid vesicles |
| EP1235914A2 (en) | 1999-11-24 | 2002-09-04 | Joseph Rosenecker | Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells |
| WO2011072246A2 (en) | 2009-12-10 | 2011-06-16 | Regents Of The University Of Minnesota | Tal effector-mediated dna modification |
| DE102010025907A1 (de) | 2010-07-02 | 2012-01-05 | Robert Bosch Gmbh | Wellenenergiewandler zur Umwandlung von kinetischer Energie in elektrische Energie |
| US9181535B2 (en) | 2012-09-24 | 2015-11-10 | The Chinese University Of Hong Kong | Transcription activator-like effector nucleases (TALENs) |
| US9359599B2 (en) | 2013-08-22 | 2016-06-07 | President And Fellows Of Harvard College | Engineered transcription activator-like effector (TALE) domains and uses thereof |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
| US10077453B2 (en) | 2014-07-30 | 2018-09-18 | President And Fellows Of Harvard College | CAS9 proteins including ligand-dependent inteins |
| WO2017068077A1 (en) * | 2015-10-20 | 2017-04-27 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Methods and products for genetic engineering |
| IL310721B2 (en) | 2015-10-23 | 2025-11-01 | Harvard College | Nucleobase editors and uses thereof |
| CN110214183A (zh) | 2016-08-03 | 2019-09-06 | 哈佛大学的校长及成员们 | 腺苷核碱基编辑器及其用途 |
| KR20240116572A (ko) * | 2017-03-23 | 2024-07-29 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 핵산 프로그램가능한 dna 결합 단백질을 포함하는 핵염기 편집제 |
| CN111801345A (zh) | 2017-07-28 | 2020-10-20 | 哈佛大学的校长及成员们 | 使用噬菌体辅助连续进化(pace)的进化碱基编辑器的方法和组合物 |
| US12157760B2 (en) * | 2018-05-23 | 2024-12-03 | The Broad Institute, Inc. | Base editors and uses thereof |
| WO2020102709A1 (en) * | 2018-11-16 | 2020-05-22 | The Regents Of The University Of California | Compositions and methods for delivering crispr/cas effector polypeptides |
-
2022
- 2022-12-02 EP EP22851442.8A patent/EP4441073A2/en active Pending
- 2022-12-02 JP JP2024533013A patent/JP2024544012A/ja active Pending
- 2022-12-02 WO PCT/US2022/080834 patent/WO2023102537A2/en not_active Ceased
- 2022-12-02 KR KR1020247022051A patent/KR20240112361A/ko active Pending
- 2022-12-02 IL IL312889A patent/IL312889A/en unknown
- 2022-12-02 US US18/715,569 patent/US20250382334A1/en active Pending
- 2022-12-02 CA CA3238778A patent/CA3238778A1/en active Pending
- 2022-12-02 AU AU2022400961A patent/AU2022400961A1/en active Pending
- 2022-12-02 GB GB2409656.2A patent/GB2630190A/en active Pending
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