JP2024544012A - 核酸プログラマブル融合タンパク質を送達するためのセルフアセンブルウイルス様粒子ならびにその作製方法および使用方法 - Google Patents

核酸プログラマブル融合タンパク質を送達するためのセルフアセンブルウイルス様粒子ならびにその作製方法および使用方法 Download PDF

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JP2024544012A
JP2024544012A JP2024533013A JP2024533013A JP2024544012A JP 2024544012 A JP2024544012 A JP 2024544012A JP 2024533013 A JP2024533013 A JP 2024533013A JP 2024533013 A JP2024533013 A JP 2024533013A JP 2024544012 A JP2024544012 A JP 2024544012A
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virus
protein
nes
gag
particle
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リウ，デイヴィッド，アール．
ラグラム，アディチャ
バンスコータ，サマギャ
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Broad Institute Inc
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JP2024533013A 2021-12-03 2022-12-02 核酸プログラマブル融合タンパク質を送達するためのセルフアセンブルウイルス様粒子ならびにその作製方法および使用方法 Pending JP2024544012A (ja)

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US202163285995P 2021-12-03 2021-12-03
US63/285,995 2021-12-03
US202263298621P 2022-01-11 2022-01-11
US63/298,621 2022-01-11
PCT/US2022/080834 WO2023102537A2 (en) 2021-12-03 2022-12-02 Self-assembling virus-like particles for delivery of nucleic acid programmable fusion proteins and methods of making and using same

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US (1) US20250382334A1 (https=)
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AU (1) AU2022400961A1 (https=)
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WO2020191233A1 (en) 2019-03-19 2020-09-24 The Broad Institute, Inc. Methods and compositions for editing nucleotide sequences
US12473543B2 (en) 2019-04-17 2025-11-18 The Broad Institute, Inc. Adenine base editors with reduced off-target effects
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WO2025137543A1 (en) * 2023-12-22 2025-06-26 President And Fellows Of Harvard College Methods for screening for next generation nucleic acid delivery vectors
CN118126137A (zh) * 2024-01-19 2024-06-04 微光基因(苏州)有限公司 用于递送核酸和蛋白质的类病毒样蛋白颗粒及其制备方法
CN118086408A (zh) * 2024-04-25 2024-05-28 华南理工大学 一种可实现靶向肌肉细胞基因编辑的仿病毒颗粒及其制备方法和应用
WO2026024856A2 (en) 2024-07-23 2026-01-29 The Broad Institute, Inc. Compositions and methods for production of double-stranded dna in cells for programmable gene integration
CN119162152B (zh) * 2024-11-18 2025-02-25 南京农业大学三亚研究院 一种扩大编辑范围且提高编辑效率的高精准碱基编辑器

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