JP2024542194A - Ｄｉｃｋｋｏｐｆ－１バリアント抗体及び使用方法 - Google Patents

Ｄｉｃｋｋｏｐｆ－１バリアント抗体及び使用方法 Download PDF

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JP2024542194A
JP2024542194A JP2024529460A JP2024529460A JP2024542194A JP 2024542194 A JP2024542194 A JP 2024542194A JP 2024529460 A JP2024529460 A JP 2024529460A JP 2024529460 A JP2024529460 A JP 2024529460A JP 2024542194 A JP2024542194 A JP 2024542194A
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antibody
fragment
examples
seq
nos
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JP2024542194A5 (https=
Inventor
サトウ，アーロン
ユアン，トム
ワン，リンヤ
アクセルロッド，フミコ
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ツイスト バイオサイエンス コーポレーション
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Publication of JP2024542194A5 publication Critical patent/JP2024542194A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2024529460A 2021-11-18 2022-11-17 Ｄｉｃｋｋｏｐｆ－１バリアント抗体及び使用方法 Pending JP2024542194A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US202163280840P 2021-11-18 2021-11-18
US63/280,840 2021-11-18
US202163286522P 2021-12-06 2021-12-06
US63/286,522 2021-12-06
US202263374497P 2022-09-02 2022-09-02
US63/374,497 2022-09-02
US202263379634P 2022-10-14 2022-10-14
US63/379,634 2022-10-14
PCT/US2022/050322 WO2023091614A2 (en) 2021-11-18 2022-11-17 Dickkopf-1 variant antibodies and methods of use

Publications (2)

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JP2024542194A true JP2024542194A (ja) 2024-11-13
JP2024542194A5 JP2024542194A5 (https=) 2025-11-25

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JP2024529460A Pending JP2024542194A (ja) 2021-11-18 2022-11-17 Ｄｉｃｋｋｏｐｆ－１バリアント抗体及び使用方法

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US (2) US12134656B2 (https=)
EP (1) EP4433085A2 (https=)
JP (1) JP2024542194A (https=)
KR (1) KR20240101677A9 (https=)
AU (1) AU2022390457A1 (https=)
CA (1) CA3238160A1 (https=)
IL (1) IL312714A (https=)
WO (1) WO2023091614A2 (https=)

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Also Published As

Publication number Publication date
US12134656B2 (en) 2024-11-05
EP4433085A2 (en) 2024-09-25
US20230312749A1 (en) 2023-10-05
AU2022390457A1 (en) 2024-06-20
US20250075004A1 (en) 2025-03-06
CA3238160A1 (en) 2023-05-25
IL312714A (en) 2024-07-01
WO2023091614A3 (en) 2023-11-02
WO2023091614A2 (en) 2023-05-25
KR20240101677A (ko) 2024-07-02
KR20240101677A9 (ko) 2025-12-10

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