IL312714A - DICKKOPF-1 variant antibodies and methods of use - Google Patents

DICKKOPF-1 variant antibodies and methods of use

Info

Publication number
IL312714A
IL312714A IL312714A IL31271424A IL312714A IL 312714 A IL312714 A IL 312714A IL 312714 A IL312714 A IL 312714A IL 31271424 A IL31271424 A IL 31271424A IL 312714 A IL312714 A IL 312714A
Authority
IL
Israel
Prior art keywords
dickkopf
methods
variant antibodies
antibodies
variant
Prior art date
Application number
IL312714A
Other languages
English (en)
Hebrew (he)
Original Assignee
Twist Bioscience Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Twist Bioscience Corp filed Critical Twist Bioscience Corp
Publication of IL312714A publication Critical patent/IL312714A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
IL312714A 2021-11-18 2022-11-17 DICKKOPF-1 variant antibodies and methods of use IL312714A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163280840P 2021-11-18 2021-11-18
US202163286522P 2021-12-06 2021-12-06
US202263374497P 2022-09-02 2022-09-02
US202263379634P 2022-10-14 2022-10-14
PCT/US2022/050322 WO2023091614A2 (en) 2021-11-18 2022-11-17 Dickkopf-1 variant antibodies and methods of use

Publications (1)

Publication Number Publication Date
IL312714A true IL312714A (en) 2024-07-01

Family

ID=86397718

Family Applications (1)

Application Number Title Priority Date Filing Date
IL312714A IL312714A (en) 2021-11-18 2022-11-17 DICKKOPF-1 variant antibodies and methods of use

Country Status (8)

Country Link
US (2) US12134656B2 (https=)
EP (1) EP4433085A2 (https=)
JP (1) JP2024542194A (https=)
KR (1) KR20240101677A9 (https=)
AU (1) AU2022390457A1 (https=)
CA (1) CA3238160A1 (https=)
IL (1) IL312714A (https=)
WO (1) WO2023091614A2 (https=)

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Also Published As

Publication number Publication date
JP2024542194A (ja) 2024-11-13
US12134656B2 (en) 2024-11-05
EP4433085A2 (en) 2024-09-25
US20230312749A1 (en) 2023-10-05
AU2022390457A1 (en) 2024-06-20
US20250075004A1 (en) 2025-03-06
CA3238160A1 (en) 2023-05-25
WO2023091614A3 (en) 2023-11-02
WO2023091614A2 (en) 2023-05-25
KR20240101677A (ko) 2024-07-02
KR20240101677A9 (ko) 2025-12-10

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