JP2024534610A5 - - Google Patents

Info

Publication number
JP2024534610A5
JP2024534610A5 JP2024518761A JP2024518761A JP2024534610A5 JP 2024534610 A5 JP2024534610 A5 JP 2024534610A5 JP 2024518761 A JP2024518761 A JP 2024518761A JP 2024518761 A JP2024518761 A JP 2024518761A JP 2024534610 A5 JP2024534610 A5 JP 2024534610A5
Authority
JP
Japan
Application number
JP2024518761A
Other languages
Japanese (ja)
Other versions
JP2024534610A (ja
JPWO2023046135A5 (https=
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/CN2022/121202 external-priority patent/WO2023046135A1/en
Publication of JP2024534610A publication Critical patent/JP2024534610A/ja
Publication of JP2024534610A5 publication Critical patent/JP2024534610A5/ja
Publication of JPWO2023046135A5 publication Critical patent/JPWO2023046135A5/ja
Pending legal-status Critical Current

Links

JP2024518761A 2021-09-27 2022-09-26 多環式縮合環誘導体およびその利用 Pending JP2024534610A (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
CNPCT/CN2021/120863 2021-09-27
CN2021120863 2021-09-27
CNPCT/CN2022/081601 2022-03-18
CN2022081601 2022-03-18
CNPCT/CN2022/102280 2022-06-29
CN2022102280 2022-06-29
CN2022120205 2022-09-21
CNPCT/CN2022/120205 2022-09-21
PCT/CN2022/121202 WO2023046135A1 (en) 2021-09-27 2022-09-26 Polycyclic fused ring derivatives and use thereof

Publications (3)

Publication Number Publication Date
JP2024534610A JP2024534610A (ja) 2024-09-20
JP2024534610A5 true JP2024534610A5 (https=) 2025-09-16
JPWO2023046135A5 JPWO2023046135A5 (https=) 2025-09-16

Family

ID=85720111

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024518761A Pending JP2024534610A (ja) 2021-09-27 2022-09-26 多環式縮合環誘導体およびその利用

Country Status (6)

Country Link
US (1) US20250034166A1 (https=)
EP (1) EP4408851A4 (https=)
JP (1) JP2024534610A (https=)
KR (1) KR20240070619A (https=)
CN (1) CN118019746A (https=)
WO (1) WO2023046135A1 (https=)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210006356A (ko) 2018-04-04 2021-01-18 아비나스 오퍼레이션스, 인코포레이티드 단백질분해 조절제 및 연관된 사용 방법
CN114867726B (zh) 2019-10-28 2023-11-28 默沙东有限责任公司 Kras g12c突变体的小分子抑制剂
US12479834B2 (en) 2019-11-29 2025-11-25 Taiho Pharmaceutical Co., Ltd. Phenol compound or salt thereof
TW202400170A (zh) 2022-05-19 2024-01-01 美商建南德克公司 氮雜-四環氧氮呯化合物及其用途
MA71388A (fr) * 2022-07-05 2025-04-30 Pfizer Inc. Composés pyrido[4,3-d]pyrimidines
WO2024015262A1 (en) * 2022-07-09 2024-01-18 Blossomhill Therapeutics, Inc. Fused ring kras inhibitors for treating disease
CA3261681A1 (en) 2022-08-05 2024-02-08 Kumquat Biosciences Inc. HETEROCYCLIC COMPOUNDS AND THEIR USES
WO2024032703A1 (en) * 2022-08-11 2024-02-15 Beigene, Ltd. Heterocyclic compounds, compositions thereof, and methods of treatment therewith
TW202408512A (zh) * 2022-08-12 2024-03-01 大陸商正大天晴藥業集團股份有限公司 三環類化合物及其醫藥用途
WO2024041573A1 (en) * 2022-08-25 2024-02-29 Zai Lab (Shanghai) Co., Ltd. Fused multi-heterocyclic compounds as kras g12d modulators and uses thereof
WO2024112654A1 (en) 2022-11-21 2024-05-30 Treeline Biosciences, Inc. Spirocyclic dihydropyranopyrimidine kras inhibitors
KR20250120376A (ko) * 2022-12-07 2025-08-08 자코바이오 파마슈티칼스 컴퍼니 리미티드 축합환 화합물 및 이의 응용
CN121419983A (zh) 2023-01-26 2026-01-27 阿尔维纳斯运营股份有限公司 基于小脑蛋白的kras降解protac及其相关用途
WO2024178304A1 (en) * 2023-02-24 2024-08-29 Alterome Therapeutics, Inc. Kras modulators
EP4687905A1 (en) 2023-03-30 2026-02-11 Revolution Medicines, Inc. Compositions for inducing ras gtp hydrolysis and uses thereof
WO2024209339A1 (en) 2023-04-05 2024-10-10 Pfizer Inc. Pyrido[4,3-d]pyrimidine compounds
WO2024208305A1 (zh) * 2023-04-07 2024-10-10 江苏恒瑞医药股份有限公司 稠合四环类化合物、其制备方法及其在医药上的应用
WO2024213979A1 (en) * 2023-04-10 2024-10-17 Pfizer Inc. Pyrido[4,3-d]pyrimidine compounds
CN120882725A (zh) * 2023-04-11 2025-10-31 吉利德科学公司 Kras调节化合物
WO2024218686A1 (en) * 2023-04-20 2024-10-24 Pfizer Inc. Pyrido[4,3-d]pyrimidine compounds
AU2024265078A1 (en) 2023-05-04 2025-12-11 Revolution Medicines, Inc. Combination therapy for a ras related disease or disorder
EP4713330A1 (en) * 2023-05-16 2026-03-25 HUTCHMED Limited Tricyclic compounds and uses thereof
WO2025006783A2 (en) * 2023-06-30 2025-01-02 Merck Patent Gmbh Heterobifunctional compounds for the degradation of kras
IL326136A (en) 2023-08-07 2026-03-01 Revolution Medicines Inc RMC-6291 for use in the treatment of a disease or disorder associated with the RAS protein
AU2024323424A1 (en) 2023-08-17 2026-03-05 Treeline Biosciences, Inc. Spirocyclic dihydropyranopyrimidine kras inhibitors
WO2025049619A1 (en) 2023-08-29 2025-03-06 Quanta Therapeutics, Inc. Kras modulators and uses thereof
AU2024337913A1 (en) 2023-09-08 2026-03-26 Gilead Sciences, Inc. Pyrimidine-containing polycyclic derivatives as kras g12d modulating compounds
TW202528315A (zh) 2023-09-21 2025-07-16 美商樹線生物科學公司 螺環二氫哌喃并吡啶KRas抑制劑
US20250154171A1 (en) 2023-10-12 2025-05-15 Revolution Medicines, Inc. Ras inhibitors
WO2025085748A1 (en) * 2023-10-20 2025-04-24 Merck Sharp & Dohme Llc Small molecule inhibitors of kras proteins
CN117700374A (zh) * 2023-12-25 2024-03-15 吉尔多肽生物制药(大连市)有限公司 手性高吗啉-3-甲酸的制备方法
WO2025148868A1 (zh) * 2024-01-08 2025-07-17 泰励生物科技(上海)有限公司 一种抗体偶联药物及其用途
WO2025168072A1 (en) * 2024-02-08 2025-08-14 Beigene (Suzhou) Co., Ltd. Heterocyclic compounds, compositions thereof, and methods of treatment therewith
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors
WO2025245127A1 (en) 2024-05-21 2025-11-27 Treeline Biosciences, Inc. Spirocyclic dihydropyranopyrimidine kras inhibitors
US20250375445A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026035945A1 (en) 2024-08-07 2026-02-12 Tesseract Medicines Us, Llc Covalent-induced drug conjugates targeting kras and comprising a topoisomerase payload
WO2026035947A1 (en) 2024-08-07 2026-02-12 Tesseract Medicines Us, Llc Kras-targeting covalent-induced drug conjugates comprising a topoisomerase payload
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026064527A1 (en) 2024-09-19 2026-03-26 Tesseract Medicines Us, Llc Kras-targeting covalent-induced drug conjugates comprising a tubulin inhibitor payload
WO2026064520A1 (en) 2024-09-19 2026-03-26 Tesseract Medicines Us, Llc Covalent-induced drug conjugates targeting kras and comprising a tubulin inhibitor payload
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5962453A (en) * 1995-08-08 1999-10-05 Nippon Shinyaku Co. Ltd. Triazine derivative and medicine
KR20080036957A (ko) * 2005-06-23 2008-04-29 아스트라제네카 아베 위장 질환 치료용 뉴로키닌 수용체 길항제로서의 신규한아제티딘 유도체
CN102875556B (zh) * 2011-07-12 2016-03-30 天津药明康德新药开发有限公司 (4s)-1-取代-2,5-二氮杂双环[2,2,1]庚烷衍生物及制备方法
US9181288B2 (en) * 2014-01-16 2015-11-10 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
WO2018206539A1 (en) * 2017-05-11 2018-11-15 Astrazeneca Ab Heteroaryl compounds that inhibit g12c mutant ras proteins
TW202012415A (zh) * 2018-05-08 2020-04-01 瑞典商阿斯特捷利康公司 化學化合物
MX2022001421A (es) * 2019-08-02 2022-06-08 Shanghai Jemincare Pharmaceuticals Co Ltd Compuesto tetracíclico, método de preparación y uso del mismo.
CN112390818B (zh) * 2019-08-12 2023-08-22 劲方医药科技(上海)有限公司 取代的杂芳环并二氢嘧啶酮衍生物,其制法与医药上的用途
EP4065231A1 (en) * 2019-11-27 2022-10-05 Revolution Medicines, Inc. Covalent ras inhibitors and uses thereof
CA3210167A1 (en) * 2021-02-09 2022-08-18 Genentech, Inc. Tetracyclic oxazepine compounds and uses thereof
WO2022188729A1 (en) * 2021-03-07 2022-09-15 Jacobio Pharmaceuticals Co., Ltd. Fused ring derivatives useful as kras g12d inhibitors
EP4310091A4 (en) * 2021-03-17 2025-04-16 Genfleet Therapeutics (Shanghai) Inc. Pyrimidine-fused cyclic compound, preparation method therefor and use thereof
CN116113632B (zh) * 2021-03-30 2025-08-29 浙江海正药业股份有限公司 杂环类衍生物、其制备方法及其医药上的用途
CN117255793A (zh) * 2021-06-21 2023-12-19 江苏恒瑞医药股份有限公司 稠合四环类化合物、其制备方法及其在医药上的应用

Similar Documents

Publication Publication Date Title
JP2025525406A5 (https=)
JP2024534610A5 (https=)
CL2025003455A1 (es) Forma cristalina de 4-(((etil(metil)amino)metilen)amino)-2,5-dimetilbenzoato de 4-(difluorometoxi)bencilo o una de sus sales y uso como fungicida.
BR102022025291A2 (https=)
CL2025004110A1 (es) Método para establecer una infraestructura de transporte eléctrico en una mina, método de extracción en una mina y un sistema de planificación para una mina.
CL2025002536A1 (es) Colectivos de carga para sistemas de almacenamiento de energía.
BR102023014872A2 (https=)
BR102023012440A2 (https=)
BR102023010976A2 (https=)
BR102023009641A2 (https=)
BR102023008688A2 (https=)
BR102023007252A2 (https=)
BR102023005164A2 (https=)
BR102023001877A2 (https=)
BR102023000289A2 (https=)
BR102022026909A2 (https=)
BR102022023461A2 (https=)
BR202022009269U2 (https=)
BR202022005961U2 (https=)
BR202022001779U2 (https=)
BR202022000931U2 (https=)
CN307044590S (https=)
CN307046256S (https=)
BY23963C1 (https=)
BY13176U (https=)