JP2024534162A5 - - Google Patents
Info
- Publication number
- JP2024534162A5 JP2024534162A5 JP2024513053A JP2024513053A JP2024534162A5 JP 2024534162 A5 JP2024534162 A5 JP 2024534162A5 JP 2024513053 A JP2024513053 A JP 2024513053A JP 2024513053 A JP2024513053 A JP 2024513053A JP 2024534162 A5 JP2024534162 A5 JP 2024534162A5
- Authority
- JP
- Japan
- Prior art keywords
- amino
- trifluoromethyl
- methylpiperidine
- phenol
- triazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163237049P | 2021-08-25 | 2021-08-25 | |
| US63/237,049 | 2021-08-25 | ||
| US202263311463P | 2022-02-18 | 2022-02-18 | |
| US63/311,463 | 2022-02-18 | ||
| PCT/US2022/075421 WO2023028534A1 (en) | 2021-08-25 | 2022-08-24 | Inhibitors of nlrp3 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024534162A JP2024534162A (ja) | 2024-09-18 |
| JP2024534162A5 true JP2024534162A5 (enExample) | 2025-09-02 |
Family
ID=83438923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024513053A Pending JP2024534162A (ja) | 2021-08-25 | 2022-08-24 | Ｎｌｒｐ３の阻害剤 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20240262806A1 (enExample) |
| EP (1) | EP4392414A1 (enExample) |
| JP (1) | JP2024534162A (enExample) |
| KR (1) | KR20240069714A (enExample) |
| AU (1) | AU2022334474A1 (enExample) |
| CA (1) | CA3229539A1 (enExample) |
| CL (1) | CL2024000552A1 (enExample) |
| CO (1) | CO2024001922A2 (enExample) |
| CR (1) | CR20240093A (enExample) |
| EC (1) | ECSP24014832A (enExample) |
| IL (1) | IL310992A (enExample) |
| MX (1) | MX2024002342A (enExample) |
| PE (1) | PE20241727A1 (enExample) |
| WO (1) | WO2023028534A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11618751B1 (en) | 2022-03-25 | 2023-04-04 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 derivatives |
| US11319319B1 (en) | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| TW202319055A (zh) * | 2021-07-21 | 2023-05-16 | 日商安斯泰來製藥股份有限公司 | 縮環噠嗪（ｐｙｒｉｄａｚｉｎｅ）化合物 |
| CN118302417A (zh) * | 2021-08-25 | 2024-07-05 | Ptc医疗公司 | Nlrp3抑制剂 |
| WO2023051761A1 (zh) * | 2021-09-30 | 2023-04-06 | 成都奥睿药业有限公司 | 一类取代杂芳酞嗪衍生物的药学用途及其制备方法 |
| WO2023088856A1 (en) | 2021-11-17 | 2023-05-25 | F. Hoffmann-La Roche Ag | Heterocyclic nlrp3 inhibitors |
| WO2023178099A1 (en) * | 2022-03-15 | 2023-09-21 | Zomagen Biosciences Ltd | Nlrp3 modulators |
| CA3246681A1 (en) * | 2022-03-25 | 2023-09-28 | Ventus Therapeutics U.S., Inc. | PYRIDO-[3,4-D]PYRIDAZINE AMINE DERIVATIVES USEFUL AS NLRP3 DERIVATIVES |
| JP2025511199A (ja) * | 2022-03-31 | 2025-04-15 | ハンチョウ ハイライトゥル ファーマシューティカル カンパニー リミテッド | Ｎｌｒｐ３インフラマソーム阻害剤 |
| US20260015357A1 (en) * | 2022-07-01 | 2026-01-15 | Neumora Therapeutics, Inc. | Modulators of nlrp3 inflammasome and related products and methods |
| JP2025524640A (ja) * | 2022-07-14 | 2025-07-30 | エーシー・イミューン・エス・アー | Ｎｌｒｐ３インフラマソーム経路の調節剤としてのピロロトリアジン及びイミダゾトリアジン誘導体 |
| JP2025023868A (ja) * | 2022-09-23 | 2025-02-17 | メルク・シャープ・アンド・ドーム・エルエルシー | Ｎｏｄ様受容体タンパク質３の阻害剤として有用なフタラジン誘導体 |
| IL319619A (en) * | 2022-09-23 | 2025-05-01 | Merck Sharp & Dohme Llc | Phthalazine derivatives used as NOD-LIKE PROTEIN 3 receptor inhibitors |
| US12331048B2 (en) | 2022-10-31 | 2025-06-17 | Ventus Therapeutics U.S., Inc. | Pyrido-[3,4-d]pyridazine amine derivatives useful as NLRP3 inhibitors |
| AU2023371859A1 (en) * | 2022-11-04 | 2025-06-12 | Transthera Sciences (Nanjing) , Inc. | Nlrp3 inflammasome inhibitor and use thereof |
| CN120379995A (zh) * | 2022-12-27 | 2025-07-25 | 正大天晴药业集团股份有限公司 | 一种哒嗪稠芳环化合物及其用途 |
| KR20250106322A (ko) * | 2022-12-28 | 2025-07-09 | 장춘 진사이언스 파마슈티컬 씨오., 엘티디. | 피리다진계 nlrp3 억제제 화합물, 약학 조성물 및 이의 제조 방법과 용도 |
| JP2026504419A (ja) * | 2023-01-31 | 2026-02-05 | ヤンセン ファーマシューティカ エヌ．ベー． | Ｎｌｒｐ３阻害剤としての２－（ピリダジン－３－イル）－５－（トリフルオロメチル）フェノール |
| KR20250134147A (ko) * | 2023-01-31 | 2025-09-09 | 얀센 파마슈티카 엔브이 | NLRP3 억제제로서의 피롤로[1,2-d][1,2,4]트리아진 및 피라졸로[1,5-d] [1,2,4]트리아진 |
| AR132116A1 (es) * | 2023-03-14 | 2025-05-28 | Sanofi Sa | Compuestos de piridazina, su preparación y sus usos terapéuticos |
| TW202448892A (zh) * | 2023-04-17 | 2024-12-16 | 大陸商上海拓界生物醫藥科技有限公司 | 稠合噠嗪類衍生物及其用途 |
| KR20260027946A (ko) | 2023-06-02 | 2026-03-03 | 머크 샤프 앤드 돔 엘엘씨 | Nod-유사 수용체 단백질 3의 억제제로서 유용한 5,6 불포화 비시클릭 헤테로사이클 |
| CN121909186A (zh) * | 2023-06-27 | 2026-04-21 | 唯久生物(美国)有限公司 | 作为nlrp3活性抑制剂的取代哒嗪化合物及其治疗用途 |
| WO2025133307A1 (en) * | 2023-12-22 | 2025-06-26 | Ac Immune Sa | Heterocyclic modulators of the nlrp3 inflammasome pathway |
| WO2025146160A1 (zh) * | 2024-01-05 | 2025-07-10 | 北京普祺医药科技股份有限公司 | 杂环化合物及其药物组合物 |
| WO2025153532A1 (en) | 2024-01-16 | 2025-07-24 | NodThera Limited | Nlrp3 inhibitors and glp-1 agonists combination therapies |
| WO2025153624A1 (en) * | 2024-01-17 | 2025-07-24 | Ac Immune Sa | Imidazo[1,2-d][1,2,4]triazine derivatives for use as inhibitors of the nlrp3 inflammasome pathway |
| WO2025153625A1 (en) * | 2024-01-17 | 2025-07-24 | Ac Immune Sa | Imidazo[1,2-d][1,2,4]triazine derivatives for use as inhibitors of the nlrp3 inflammasome pathway |
| WO2026002229A1 (zh) * | 2024-06-28 | 2026-01-02 | 长春金赛药业有限责任公司 | 一种nlrp3抑制剂化合物及其制备方法和应用 |
| WO2026047040A1 (en) * | 2024-08-28 | 2026-03-05 | Sanofi | Pyridazine compounds, their preparation, and their therapeutic uses |
| WO2026057747A1 (en) | 2024-09-11 | 2026-03-19 | Ac Immune Sa | Therapeutic use of nlrp3 inflammasome pathway inhibitor compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9919957D0 (en) * | 1999-08-23 | 1999-10-27 | Merck Sharp & Dohme | Therapeutic agents |
| WO2006075638A1 (ja) | 2005-01-14 | 2006-07-20 | Dainippon Sumitomo Pharma Co., Ltd. | 新規ヘテロアリール誘導体 |
| US8222251B2 (en) * | 2007-09-07 | 2012-07-17 | Amgen Inc. | Pyridopyridazine compounds, compositions and methods of use |
| US10947241B2 (en) * | 2016-10-28 | 2021-03-16 | Seoul National University Hospital | Phenyl phthalazine derivative, method for the preparation thereof, and pharmaceutical composition comprising the same |
| WO2020231977A1 (en) | 2019-05-13 | 2020-11-19 | Ptc Therapeutics, Inc. | Compounds for treating huntington's disease |
| AR119731A1 (es) | 2019-05-17 | 2022-01-05 | Novartis Ag | Inhibidores del inflamasoma nlrp3 |
| WO2020239076A1 (zh) | 2019-05-29 | 2020-12-03 | 南京明德新药研发有限公司 | 作为甲状腺素受体-β激动剂的哒嗪酮类衍生物及其应用 |
| WO2022135567A1 (zh) * | 2020-12-25 | 2022-06-30 | 上海拓界生物医药科技有限公司 | 一类含哒嗪的化合物及其医药用途 |
| US11319319B1 (en) * | 2021-04-07 | 2022-05-03 | Ventus Therapeutics U.S., Inc. | Compounds for inhibiting NLRP3 and uses thereof |
| EP4362946A4 (en) | 2021-06-29 | 2025-05-21 | Zomagen Biosciences Ltd | Nlrp3 modulators |
| LT4363406T (lt) | 2021-07-02 | 2025-12-29 | Astrazeneca Ab | Nlrp3 inflamasomų inhibitoriai |
| TW202319055A (zh) | 2021-07-21 | 2023-05-16 | 日商安斯泰來製藥股份有限公司 | 縮環噠嗪（ｐｙｒｉｄａｚｉｎｅ）化合物 |
-
2022
- 2022-08-24 CR CR20240093A patent/CR20240093A/es unknown
- 2022-08-24 PE PE2024000299A patent/PE20241727A1/es unknown
- 2022-08-24 AU AU2022334474A patent/AU2022334474A1/en active Pending
- 2022-08-24 EP EP22777142.5A patent/EP4392414A1/en active Pending
- 2022-08-24 WO PCT/US2022/075421 patent/WO2023028534A1/en not_active Ceased
- 2022-08-24 IL IL310992A patent/IL310992A/en unknown
- 2022-08-24 CA CA3229539A patent/CA3229539A1/en active Pending
- 2022-08-24 US US18/256,099 patent/US20240262806A1/en active Pending
- 2022-08-24 KR KR1020247005965A patent/KR20240069714A/ko active Pending
- 2022-08-24 MX MX2024002342A patent/MX2024002342A/es unknown
- 2022-08-24 JP JP2024513053A patent/JP2024534162A/ja active Pending
-
2024
- 2024-02-22 CL CL2024000552A patent/CL2024000552A1/es unknown
- 2024-02-22 CO CONC2024/0001922A patent/CO2024001922A2/es unknown
- 2024-02-23 EC ECSENADI202414832A patent/ECSP24014832A/es unknown
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