JP2024532620A - 抗ＩＬ－１１Ｒα抗体 - Google Patents

抗ＩＬ－１１Ｒα抗体 Download PDF

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Publication number
JP2024532620A
JP2024532620A JP2024537308A JP2024537308A JP2024532620A JP 2024532620 A JP2024532620 A JP 2024532620A JP 2024537308 A JP2024537308 A JP 2024537308A JP 2024537308 A JP2024537308 A JP 2024537308A JP 2024532620 A JP2024532620 A JP 2024532620A
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JP
Japan
Prior art keywords
seq
sequence
cdr1
cdr2
nos
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Pending
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JP2024537308A
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English (en)
Japanese (ja)
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JP2024532620A5 (cg-RX-API-DMAC10.html
Inventor
エイ ホーリック，ロバート
トニ ジュン，ヘレン
ジェイ キング，デイビッド
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Lassen Therapeutics 1 Inc
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Lassen Therapeutics 1 Inc
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Application filed by Lassen Therapeutics 1 Inc filed Critical Lassen Therapeutics 1 Inc
Publication of JP2024532620A publication Critical patent/JP2024532620A/ja
Publication of JP2024532620A5 publication Critical patent/JP2024532620A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/71—Decreased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/75—Agonist effect on antigen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2024537308A 2021-08-30 2022-08-30 抗ＩＬ－１１Ｒα抗体 Pending JP2024532620A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202163238443P 2021-08-30 2021-08-30
US63/238,443 2021-08-30
US202263334923P 2022-04-26 2022-04-26
US63/334,923 2022-04-26
PCT/US2022/075680 WO2023034809A1 (en) 2021-08-30 2022-08-30 Anti-il-11rα antibodies

Publications (2)

Publication Number Publication Date
JP2024532620A true JP2024532620A (ja) 2024-09-05
JP2024532620A5 JP2024532620A5 (cg-RX-API-DMAC10.html) 2025-09-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2024537308A Pending JP2024532620A (ja) 2021-08-30 2022-08-30 抗ＩＬ－１１Ｒα抗体

Country Status (9)

Country Link
US (5) US20240425606A1 (cg-RX-API-DMAC10.html)
EP (1) EP4396236A4 (cg-RX-API-DMAC10.html)
JP (1) JP2024532620A (cg-RX-API-DMAC10.html)
KR (1) KR20240067079A (cg-RX-API-DMAC10.html)
AU (1) AU2022339767A1 (cg-RX-API-DMAC10.html)
CA (1) CA3230523A1 (cg-RX-API-DMAC10.html)
IL (1) IL311043A (cg-RX-API-DMAC10.html)
MX (1) MX2024002611A (cg-RX-API-DMAC10.html)
WO (1) WO2023034809A1 (cg-RX-API-DMAC10.html)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024532620A (ja) 2021-08-30 2024-09-05 ラッセン・セラピューティクス１・インコーポレイテッド 抗ＩＬ－１１Ｒα抗体
WO2024148240A1 (en) * 2023-01-06 2024-07-11 Lassen Therapeutics 1, Inc. ANTI-IL-11Rα ANTIBODIES FOR TREATING THYROID EYE DISEASE
CN120518762B (zh) * 2023-06-05 2025-12-26 北京东方百泰生物科技股份有限公司 一种结合il-11的抗体、其抗原结合片段及应用
TW202612733A (zh) * 2024-06-07 2026-04-01 美商拉森醫療公司 抗ＩＬ－１１Ｒα抗體在治療甲狀腺眼病中之給藥
WO2025255486A2 (en) * 2024-06-07 2025-12-11 Lassen Therapeutics, Inc. DOSING OF ANTI-IL-11Rα ANTIBODIES IN THE TREATMENT OF IDIOPATHIC PULMONARY FIBROSIS

Citations (2)

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JP2016515094A (ja) * 2013-02-07 2016-05-26 シーエスエル、リミテッド Ｉｌ−１１ｒ結合タンパク質及びその使用

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Patent Citations (2)

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JP2016515094A (ja) * 2013-02-07 2016-05-26 シーエスエル、リミテッド Ｉｌ−１１ｒ結合タンパク質及びその使用

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US20250368746A1 (en) 2025-12-04
IL311043A (en) 2024-04-01
US20240425606A1 (en) 2024-12-26
CA3230523A1 (en) 2023-03-09
US20250011444A1 (en) 2025-01-09
AU2022339767A1 (en) 2024-04-11
MX2024002611A (es) 2024-05-29
KR20240067079A (ko) 2024-05-16
US20260008858A1 (en) 2026-01-08
US20240199753A1 (en) 2024-06-20
WO2023034809A1 (en) 2023-03-09
EP4396236A4 (en) 2025-10-01
EP4396236A1 (en) 2024-07-10
US12129303B2 (en) 2024-10-29
US12365738B2 (en) 2025-07-22

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