JP2024532238A - 抗体薬物複合体のフロースルー陽イオン交換クロマトグラフィー精製方法 - Google Patents

抗体薬物複合体のフロースルー陽イオン交換クロマトグラフィー精製方法 Download PDF

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Publication number
JP2024532238A
JP2024532238A JP2024510666A JP2024510666A JP2024532238A JP 2024532238 A JP2024532238 A JP 2024532238A JP 2024510666 A JP2024510666 A JP 2024510666A JP 2024510666 A JP2024510666 A JP 2024510666A JP 2024532238 A JP2024532238 A JP 2024532238A
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JP
Japan
Prior art keywords
adc
purification
antibody
cys
cation exchange
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Pending
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JP2024510666A
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English (en)
Japanese (ja)
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JP2024532238A5 (enExample
Inventor
レイチェル ヘンドリックス，
マシュー ヘンリー ハッチンソン，
マーク フレデリック フェデスコ，
ベンジャミン フー トラン，
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Genentech Inc
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Genentech Inc
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Publication of JP2024532238A publication Critical patent/JP2024532238A/ja
Publication of JP2024532238A5 publication Critical patent/JP2024532238A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
    • C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
JP2024510666A 2021-08-23 2022-08-22 抗体薬物複合体のフロースルー陽イオン交換クロマトグラフィー精製方法 Pending JP2024532238A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163236170P 2021-08-23 2021-08-23
US63/236,170 2021-08-23
PCT/US2022/075252 WO2023028446A1 (en) 2021-08-23 2022-08-22 Flow through cation exchange chromatography purification processes for antibody drug conjugates

Publications (2)

Publication Number Publication Date
JP2024532238A true JP2024532238A (ja) 2024-09-05
JP2024532238A5 JP2024532238A5 (enExample) 2025-08-26

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JP2024510666A Pending JP2024532238A (ja) 2021-08-23 2022-08-22 抗体薬物複合体のフロースルー陽イオン交換クロマトグラフィー精製方法

Country Status (12)

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US (1) US20240277859A1 (enExample)
EP (1) EP4392433A1 (enExample)
JP (1) JP2024532238A (enExample)
KR (1) KR20240046733A (enExample)
CN (1) CN117881686A (enExample)
AR (1) AR126847A1 (enExample)
AU (1) AU2022332274A1 (enExample)
CA (1) CA3229079A1 (enExample)
IL (1) IL310556A (enExample)
MX (1) MX2024002133A (enExample)
TW (1) TW202323268A (enExample)
WO (1) WO2023028446A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118290513B (zh) * 2024-06-05 2025-03-14 东曜药业有限公司 一种去除抗体偶联药物中游离小分子的阴离子柱层析方法及抗体偶联药物

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130289247A1 (en) * 2010-11-01 2013-10-31 Dsm Ip Assets B.V. Single unit ion exchange chromatography antibody purification
CN104208719A (zh) * 2014-09-24 2014-12-17 北京天广实生物技术股份有限公司 一种抗体偶联药物的阳离子交换层析纯化方法
US20180311375A1 (en) * 2017-04-27 2018-11-01 Cadila Healthcare Limited Process of preparing antibody-drug conjugate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1869065T3 (da) 2005-03-11 2020-06-08 Wyeth Llc Fremgangsmåde til kromatografi med svag opdeling
SG10201701224UA (en) 2012-03-12 2017-04-27 Merck Patent Gmbh Removal of protein aggregates from biopharmaceutical preparations in a flowthrough mode

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130289247A1 (en) * 2010-11-01 2013-10-31 Dsm Ip Assets B.V. Single unit ion exchange chromatography antibody purification
CN104208719A (zh) * 2014-09-24 2014-12-17 北京天广实生物技术股份有限公司 一种抗体偶联药物的阳离子交换层析纯化方法
US20180311375A1 (en) * 2017-04-27 2018-11-01 Cadila Healthcare Limited Process of preparing antibody-drug conjugate

Also Published As

Publication number Publication date
AU2022332274A1 (en) 2024-02-15
MX2024002133A (es) 2024-03-06
EP4392433A1 (en) 2024-07-03
IL310556A (en) 2024-03-01
AR126847A1 (es) 2023-11-22
US20240277859A1 (en) 2024-08-22
CA3229079A1 (en) 2023-03-02
KR20240046733A (ko) 2024-04-09
TW202323268A (zh) 2023-06-16
CN117881686A (zh) 2024-04-12
WO2023028446A1 (en) 2023-03-02

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