JP2024528634A5 - - Google Patents
Info
- Publication number
- JP2024528634A5 JP2024528634A5 JP2024502054A JP2024502054A JP2024528634A5 JP 2024528634 A5 JP2024528634 A5 JP 2024528634A5 JP 2024502054 A JP2024502054 A JP 2024502054A JP 2024502054 A JP2024502054 A JP 2024502054A JP 2024528634 A5 JP2024528634 A5 JP 2024528634A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleotide sequence
- nucleotide
- nucleotides
- double
- stranded oligonucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202110807463 | 2021-07-16 | ||
| CN202110807463.9 | 2021-07-16 | ||
| PCT/CN2022/105340 WO2023284763A1 (zh) | 2021-07-16 | 2022-07-13 | 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024528634A JP2024528634A (ja) | 2024-07-30 |
| JP2024528634A5 true JP2024528634A5 (https=) | 2025-07-18 |
Family
ID=84919035
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024502054A Pending JP2024528634A (ja) | 2021-07-16 | 2022-07-13 | 二本鎖オリゴヌクレオチド、二本鎖オリゴヌクレオチドを含む組成物及び複合体並びに調製方法と使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20240309378A1 (https=) |
| EP (1) | EP4372086A1 (https=) |
| JP (1) | JP2024528634A (https=) |
| CN (1) | CN117580952A (https=) |
| TW (1) | TW202308665A (https=) |
| WO (1) | WO2023284763A1 (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11597744B2 (en) | 2017-06-30 | 2023-03-07 | Sirius Therapeutics, Inc. | Chiral phosphoramidite auxiliaries and methods of their use |
| JP7606758B2 (ja) * | 2019-05-22 | 2024-12-26 | スーチョウ リボ ライフ サイエンス カンパニー、リミテッド | 核酸、薬物組成物及び複合体ならびに調製方法と使用 |
| CN119421952A (zh) * | 2022-06-27 | 2025-02-11 | 大睿生物医药科技(上海)有限公司 | 抑制载脂蛋白C3表达的siRNA |
| WO2024140101A1 (zh) * | 2022-12-28 | 2024-07-04 | 北京炫景瑞医药科技有限公司 | 修饰的双链寡核苷酸分子、修饰的双链寡核苷酸缀合物及其用途 |
| TW202508607A (zh) * | 2023-05-19 | 2025-03-01 | 大陸商北京炫景瑞醫藥科技有限公司 | 雙股寡核苷酸及其共軛物和用途 |
| TW202509216A (zh) * | 2023-07-14 | 2025-03-01 | 大陸商北京安龍生物醫藥有限公司 | 靶向血管收縮素原的寡核苷酸及其用途 |
| CN121548643A (zh) * | 2023-08-08 | 2026-02-17 | 苏州炫景生物科技有限公司 | Fto抑制剂组合物及其应用 |
| CN118147134B (zh) * | 2023-11-06 | 2025-02-25 | 北京悦康科创医药科技股份有限公司 | 靶向调控PCSK9基因表达的siRNA及其应用 |
| CN117384907B (zh) * | 2023-12-11 | 2024-03-29 | 上海鼎新基因科技有限公司 | 抑制PCSK9表达的siRNA分子及其应用 |
| CN118516348B (zh) * | 2024-07-23 | 2025-01-17 | 深川生物科技(山东)股份公司 | 单链核酸或双链核酸及在制备治疗杜氏肌营养不良的药物中的应用 |
| CN118979036B (zh) * | 2024-08-01 | 2025-08-19 | 北京尧景基因技术有限公司 | 抑制APP基因表达的siRNA及其缀合物和应用 |
| WO2026052079A1 (zh) * | 2024-09-07 | 2026-03-12 | 苏州瑞博生物技术股份有限公司 | 寡核苷酸、寡核苷酸缀合物及组合物和用途 |
| CN118995718B (zh) * | 2024-10-24 | 2025-04-11 | 苏州炫景生物科技有限公司 | 含有末端核苷酸修饰的双链寡核苷酸及其在抑制agt基因表达中的应用 |
| CN119410644A (zh) * | 2025-01-08 | 2025-02-11 | 北京安龙生物医药有限公司 | 修饰的双链寡核苷酸及其缀合物和组合物 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100069461A1 (en) * | 2005-11-09 | 2010-03-18 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of factor v leiden mutant gene |
| CA2658183A1 (en) * | 2006-07-17 | 2008-01-24 | Sirna Therapeutics Inc. | Rna interference mediated inhibition of proprotein convertase subtilisin kexin 9 (pcsk9) gene expression using short interfering nucleic acid (sina) |
| WO2009073809A2 (en) | 2007-12-04 | 2009-06-11 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugates as delivery agents for oligonucleotides |
| CN102140458B (zh) | 2010-01-29 | 2013-05-22 | 苏州瑞博生物技术有限公司 | 小干扰核酸和药物组合物及其制药应用 |
| CN103380113B (zh) | 2010-11-15 | 2018-03-30 | 生命科技公司 | 含胺的转染试剂及其制备和使用方法 |
| AU2013299717B2 (en) | 2012-08-06 | 2018-06-28 | Alnylam Pharmaceuticals, Inc. | Carbohydrate conjugated RNA agents and process for their preparation |
| WO2015006740A2 (en) | 2013-07-11 | 2015-01-15 | Alnylam Pharmaceuticals, Inc. | Oligonucleotide-ligand conjugates and process for their preparation |
| EP3118315A4 (en) * | 2014-03-13 | 2017-11-15 | Kyowa Hakko Kirin Co., Ltd. | Nucleic acid that inhibits expression of irf5 |
| EP3719127A4 (en) * | 2017-12-01 | 2021-10-20 | Suzhou Ribo Life Science Co., Ltd. | NUCLEIC ACID, COMPOSITION AND CONJUGATE WITH IT, MANUFACTURING METHOD AND USE |
| CN110944675B9 (zh) * | 2017-12-01 | 2024-08-09 | 苏州瑞博生物技术股份有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
| CA3083970A1 (en) * | 2017-12-01 | 2019-06-06 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate comprising the same, and preparation method and use thereof |
| DK3719128T3 (da) * | 2017-12-01 | 2025-03-03 | Suzhou Ribo Life Science Co Ltd | Dobbelt-strenget oligonukleotid, sammensætning og konjugat bestaende dobbelt-strenget oligonukleotid, fremgangsmåde herfor og anvendelse heraf |
| EP3719126B1 (en) * | 2017-12-01 | 2025-01-01 | Suzhou Ribo Life Science Co., Ltd. | Nucleic acid, composition and conjugate containing nucleic acid, preparation method therefor and use thereof |
| AU2018394875B2 (en) | 2017-12-29 | 2023-08-03 | Suzhou Ribo Life Science Co., Ltd. | Conjugates and preparation and use thereof |
| WO2020135673A1 (zh) * | 2018-12-28 | 2020-07-02 | 苏州瑞博生物技术有限公司 | 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途 |
-
2022
- 2022-07-13 WO PCT/CN2022/105340 patent/WO2023284763A1/zh not_active Ceased
- 2022-07-13 EP EP22841396.9A patent/EP4372086A1/en active Pending
- 2022-07-13 CN CN202280046071.8A patent/CN117580952A/zh active Pending
- 2022-07-13 US US18/576,589 patent/US20240309378A1/en active Pending
- 2022-07-13 JP JP2024502054A patent/JP2024528634A/ja active Pending
- 2022-07-15 TW TW111126699A patent/TW202308665A/zh unknown
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