JP2024527525A5 - - Google Patents
Info
- Publication number
- JP2024527525A5 JP2024527525A5 JP2023579195A JP2023579195A JP2024527525A5 JP 2024527525 A5 JP2024527525 A5 JP 2024527525A5 JP 2023579195 A JP2023579195 A JP 2023579195A JP 2023579195 A JP2023579195 A JP 2023579195A JP 2024527525 A5 JP2024527525 A5 JP 2024527525A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- lnp composition
- level
- lnp
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163202744P | 2021-06-22 | 2021-06-22 | |
| US63/202,744 | 2021-06-22 | ||
| US202163202812P | 2021-06-25 | 2021-06-25 | |
| US63/202,812 | 2021-06-25 | ||
| US202163263466P | 2021-11-03 | 2021-11-03 | |
| US63/263,466 | 2021-11-03 | ||
| US202163264435P | 2021-11-22 | 2021-11-22 | |
| US63/264,435 | 2021-11-22 | ||
| US202263314878P | 2022-02-28 | 2022-02-28 | |
| US63/314,878 | 2022-02-28 | ||
| PCT/US2022/034454 WO2022271780A1 (en) | 2021-06-22 | 2022-06-22 | Methods for in vivo editing of a liver gene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024527525A JP2024527525A (ja) | 2024-07-25 |
| JP2024527525A5 true JP2024527525A5 (https=) | 2025-07-22 |
Family
ID=82655316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023579195A Pending JP2024527525A (ja) | 2021-06-22 | 2022-06-22 | 肝遺伝子のインビボ編集のための方法 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20250269062A1 (https=) |
| EP (1) | EP4359531A1 (https=) |
| JP (1) | JP2024527525A (https=) |
| KR (1) | KR20240038705A (https=) |
| AU (1) | AU2022296523A1 (https=) |
| CA (1) | CA3224995A1 (https=) |
| IL (1) | IL309055A (https=) |
| MX (1) | MX2023015213A (https=) |
| TW (1) | TW202327626A (https=) |
| WO (1) | WO2022271780A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2025128871A2 (en) | 2023-12-13 | 2025-06-19 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5378825A (en) | 1990-07-27 | 1995-01-03 | Isis Pharmaceuticals, Inc. | Backbone modified oligonucleotide analogs |
| JP3131222B2 (ja) | 1991-12-24 | 2001-01-31 | アイシス・ファーマシューティカルス・インコーポレーテッド | ギャップを有する２′修飾オリゴヌクレオチド |
| JPH10500310A (ja) | 1994-05-19 | 1998-01-13 | ダコ アクティーゼルスカブ | 淋菌及びトラコーマ クラミジアの検出のためのｐｎａ プローブ |
| EP3083556B1 (en) | 2013-12-19 | 2019-12-25 | Novartis AG | Lipids and lipid compositions for the delivery of active agents |
| CN106794141B (zh) | 2014-07-16 | 2021-05-28 | 诺华股份有限公司 | 将核酸包封在脂质纳米粒主体中的方法 |
| KR20230156800A (ko) | 2015-03-03 | 2023-11-14 | 더 제너럴 하스피탈 코포레이션 | 변경된 PAM 특이성을 갖는 조작된 CRISPR-Cas9 뉴클레아제 |
| CN120842296A (zh) | 2015-09-21 | 2025-10-28 | 垂林克生物技术有限公司 | 用于合成5’-加帽rna的组合物和方法 |
| LT3436077T (lt) | 2016-03-30 | 2025-06-25 | Intellia Therapeutics, Inc. | Lipidų nanodalelių vaisto formos, skirtos crispr/cas komponentams |
| BR112019015220B1 (pt) | 2017-09-29 | 2023-10-03 | CF&I Steel L.P. D/B/A EVRAZ Rocky Mountain Steel | Método para unir trilhos de aço com entrada de calor por solda controlada |
| EP3688161A1 (en) | 2017-09-29 | 2020-08-05 | Intellia Therapeutics, Inc. | Compositions and methods for ttr gene editing and treating attr amyloidosis |
| US20230140670A1 (en) | 2017-09-29 | 2023-05-04 | Intellia Therapeutics, Inc. | Formulations |
| US20220009878A1 (en) * | 2018-10-02 | 2022-01-13 | Intellia Therapeutics, Inc. | Ionizable amine lipids |
| AU2020248337A1 (en) * | 2019-03-28 | 2021-11-04 | Intellia Therapeutics, Inc. | Compositions and methods for ttr gene editing and treating ATTR amyloidosis comprising a corticosteroid or use thereof |
| JP7631215B2 (ja) * | 2019-03-28 | 2025-02-18 | インテリア セラピューティクス，インコーポレイテッド | Ｔｔｒガイドｒｎａと、ｒｎａガイドｄｎａ結合剤をコードするポリヌクレオチドとを含む組成物および方法 |
| WO2021046265A1 (en) * | 2019-09-06 | 2021-03-11 | Generation Bio Co. | Lipid nanoparticle compositions comprising closed-ended dna and cleavable lipids and methods of use thereof |
| EP4073249A1 (en) * | 2019-12-11 | 2022-10-19 | Intellia Therapeutics, Inc. | Modified guide rnas for gene editing |
-
2022
- 2022-06-22 KR KR1020247002171A patent/KR20240038705A/ko active Pending
- 2022-06-22 WO PCT/US2022/034454 patent/WO2022271780A1/en not_active Ceased
- 2022-06-22 CA CA3224995A patent/CA3224995A1/en active Pending
- 2022-06-22 TW TW111123229A patent/TW202327626A/zh unknown
- 2022-06-22 AU AU2022296523A patent/AU2022296523A1/en active Pending
- 2022-06-22 EP EP22744574.9A patent/EP4359531A1/en active Pending
- 2022-06-22 JP JP2023579195A patent/JP2024527525A/ja active Pending
- 2022-06-22 IL IL309055A patent/IL309055A/en unknown
- 2022-06-22 US US18/572,155 patent/US20250269062A1/en active Pending
- 2022-06-22 MX MX2023015213A patent/MX2023015213A/es unknown
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