JP2024523424A5 - - Google Patents

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Publication number
JP2024523424A5
JP2024523424A5 JP2023578074A JP2023578074A JP2024523424A5 JP 2024523424 A5 JP2024523424 A5 JP 2024523424A5 JP 2023578074 A JP2023578074 A JP 2023578074A JP 2023578074 A JP2023578074 A JP 2023578074A JP 2024523424 A5 JP2024523424 A5 JP 2024523424A5
Authority
JP
Japan
Prior art keywords
sirna
sirna molecule
sequence number
molecule according
sequence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023578074A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024523424A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/034235 external-priority patent/WO2022271624A1/en
Publication of JP2024523424A publication Critical patent/JP2024523424A/ja
Publication of JP2024523424A5 publication Critical patent/JP2024523424A5/ja
Pending legal-status Critical Current

Links

JP2023578074A 2021-06-21 2022-06-21 逆位キメラsiRNA分子およびその使用方法 Pending JP2024523424A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163212976P 2021-06-21 2021-06-21
US63/212,976 2021-06-21
PCT/US2022/034235 WO2022271624A1 (en) 2021-06-21 2022-06-21 Inverted chimeric sirna molecules and methods of use thereof

Publications (2)

Publication Number Publication Date
JP2024523424A JP2024523424A (ja) 2024-06-28
JP2024523424A5 true JP2024523424A5 (https=) 2025-06-09

Family

ID=84544739

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023578074A Pending JP2024523424A (ja) 2021-06-21 2022-06-21 逆位キメラsiRNA分子およびその使用方法

Country Status (7)

Country Link
US (1) US20240309384A1 (https=)
EP (1) EP4359536A4 (https=)
JP (1) JP2024523424A (https=)
CN (1) CN117642507A (https=)
AU (1) AU2022299035A1 (https=)
CA (1) CA3221985A1 (https=)
WO (1) WO2022271624A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202406049D0 (en) * 2024-04-30 2024-06-12 Francis Crick Institute Ltd Methods and compositions for treating tumours

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7951935B2 (en) * 2002-11-14 2011-05-31 Dharmacon, Inc. siRNA targeting v-myc myelocytomatosis viral oncogene homolog (MYC)
EP1989307B1 (en) * 2006-02-08 2012-08-08 Quark Pharmaceuticals, Inc. NOVEL TANDEM siRNAS
WO2010115202A2 (en) * 2009-04-03 2010-10-07 Dicerna Pharmaceuticals, Inc. Methods and compositions for the specific inhibition of kras by blunt ended double-stranded rna
WO2010141511A2 (en) * 2009-06-01 2010-12-09 Halo-Bio Rnai Therapeutics, Inc. Polynucleotides for multivalent rna interference, compositions and methods of use thereof
US9187746B2 (en) * 2009-09-22 2015-11-17 Alnylam Pharmaceuticals, Inc. Dual targeting siRNA agents
AU2013315543A1 (en) * 2012-09-14 2015-04-09 Dicerna Pharmaceuticals, Inc. Methods and compostions for the specific inhibition of MYC by double-stranded RNA
US10689654B2 (en) * 2016-10-18 2020-06-23 Augusta University Research Institute, Inc. Bivalent siRNA chimeras and methods of use thereof
CN108866058B (zh) * 2018-07-12 2021-09-10 苏州吉玛基因股份有限公司 靶向KRAS的siRNA及其在制备胰腺癌治疗药物中的应用

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