JP2024522116A - Ｍｕｃ１－ｃ／細胞外ドメイン（ｍｕｃ１－ｃ／ｅｃｄ）に対する多重特異性抗体構築物 - Google Patents

Ｍｕｃ１－ｃ／細胞外ドメイン（ｍｕｃ１－ｃ／ｅｃｄ）に対する多重特異性抗体構築物 Download PDF

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JP2024522116A
JP2024522116A JP2023573353A JP2023573353A JP2024522116A JP 2024522116 A JP2024522116 A JP 2024522116A JP 2023573353 A JP2023573353 A JP 2023573353A JP 2023573353 A JP2023573353 A JP 2023573353A JP 2024522116 A JP2024522116 A JP 2024522116A
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cells
muc1
antibody
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antibody construct
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サレンダー カルバンダー
ゴビンダスワミー パンチャモーシー
ドナルド ダブリュー． キーフ
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エックスワイワン セラピューティクス インコーポレイテッド
デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド
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    • C07K16/3076—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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JP2023573353A 2021-05-28 2022-05-27 Ｍｕｃ１－ｃ／細胞外ドメイン（ｍｕｃ１－ｃ／ｅｃｄ）に対する多重特異性抗体構築物 Pending JP2024522116A (ja)

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US202163194597P 2021-05-28 2021-05-28
US63/194,597 2021-05-28
PCT/US2022/031431 WO2022251695A2 (en) 2021-05-28 2022-05-27 Multi-specific antibody constructs against the muc1-c/extracellular domain ( muc1-c/ecd)

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Families Citing this family (2)

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Publication number Priority date Publication date Assignee Title
EP4644413A1 (en) * 2024-05-03 2025-11-05 Genmab B.V. Binding agents having altered fc-mediated effector functions
WO2026024841A1 (en) * 2024-07-24 2026-01-29 Astellas Us Llc Bispecific antibodies that bind cd3 and muc1 and methods of use thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017505625A (ja) * 2014-01-29 2017-02-23 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Ｍｕｃ１−ｃ／細胞外ドメイン（ｍｕｃ１−ｃ／ｅｃｄ）に対する抗体
US20180036441A1 (en) * 2016-08-05 2018-02-08 Dana-Farber Cancer Institute, Inc. Antibodies against the muc1-c/extracellular domain (muc1-c/ecd)
JP2020515532A (ja) * 2017-03-29 2020-05-28 グリコトープ ゲーエムベーハー Ｍｕｃ１およびｃｄ３に結合する多重特異的抗体構築物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080279850A1 (en) * 2005-07-25 2008-11-13 Trubion Pharmaceuticals, Inc. B-Cell Reduction Using CD37-Specific and CD20-Specific Binding Molecules
NZ573646A (en) * 2006-06-12 2012-04-27 Wyeth Llc Single-chain multivalent binding proteins with effector function
EP2604279A1 (en) * 2008-03-27 2013-06-19 ZymoGenetics, Inc. Compositions and methods for inhibiting PDGFRBETA and VEGF-A
JP2012530721A (ja) * 2009-06-18 2012-12-06 ワイス・エルエルシー 小モジュール免疫薬のための凍結乾燥製剤
US20130189268A1 (en) * 2010-06-22 2013-07-25 Precision Biologics, Inc. Colon and pancreas cancer specific antigens and antibodies
US20150038682A1 (en) * 2013-08-02 2015-02-05 Jn Biosciences Llc Antibodies or fusion proteins multimerized via homomultimerizing peptide
EP3655439A1 (en) * 2017-07-20 2020-05-27 Aptevo Research and Development LLC Antigen binding proteins binding to 5t4 and 4-1bb and related compositions and methods
JP2021502100A (ja) * 2017-11-08 2021-01-28 ゼンコア インコーポレイテッド 新規抗ｐｄ−１配列を用いた二重特異性および単一特異性抗体
SG11202008474QA (en) * 2018-03-27 2020-10-29 Systimmune Inc Guidance and navigation control proteins and method of making and using thereof
US20210115152A1 (en) * 2018-05-16 2021-04-22 Arbele Limited Composition of bispecific antibodies and method of use thereof
JP7495409B2 (ja) * 2018-09-11 2024-06-04 ドイチェス クレブスフォルシュングスツェントルム シュティフトゥング デス エッフェントリッヒェンレヒツ 改善された抗ｆｌｔ３抗原結合タンパク質

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2017505625A (ja) * 2014-01-29 2017-02-23 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Ｍｕｃ１−ｃ／細胞外ドメイン（ｍｕｃ１−ｃ／ｅｃｄ）に対する抗体
US20180036441A1 (en) * 2016-08-05 2018-02-08 Dana-Farber Cancer Institute, Inc. Antibodies against the muc1-c/extracellular domain (muc1-c/ecd)
JP2020515532A (ja) * 2017-03-29 2020-05-28 グリコトープ ゲーエムベーハー Ｍｕｃ１およびｃｄ３に結合する多重特異的抗体構築物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CANCER IMMUNOL IMMUNOTHER., vol. 55, JPN6026004080, 2006, pages 1337 - 1347, ISSN: 0005785655 *
CANCER RESEARCH, vol. 56, JPN6026004077, 1996, pages 4205 - 4212, ISSN: 0005785653 *
VACCINES, vol. 8, no. 659, JPN6026004079, 2020, pages 1 - 21, ISSN: 0005785654 *

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