JP2024521878A5 - - Google Patents
Info
- Publication number
- JP2024521878A5 JP2024521878A5 JP2023574119A JP2023574119A JP2024521878A5 JP 2024521878 A5 JP2024521878 A5 JP 2024521878A5 JP 2023574119 A JP2023574119 A JP 2023574119A JP 2023574119 A JP2023574119 A JP 2023574119A JP 2024521878 A5 JP2024521878 A5 JP 2024521878A5
- Authority
- JP
- Japan
- Prior art keywords
- halo
- alkyl
- pharmaceutically acceptable
- acceptable salt
- diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163196339P | 2021-06-03 | 2021-06-03 | |
| US63/196,339 | 2021-06-03 | ||
| US202163290019P | 2021-12-15 | 2021-12-15 | |
| US63/290,019 | 2021-12-15 | ||
| US202263346120P | 2022-05-26 | 2022-05-26 | |
| US63/346,120 | 2022-05-26 | ||
| PCT/US2022/032042 WO2022256586A2 (en) | 2021-06-03 | 2022-06-03 | Substituted indole compounds and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024521878A JP2024521878A (ja) | 2024-06-04 |
| JP2024521878A5 true JP2024521878A5 (OSRAM) | 2025-06-02 |
Family
ID=84323595
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023574119A Pending JP2024521878A (ja) | 2021-06-03 | 2022-06-03 | 置換インドール化合物及びその使用方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US20240287034A1 (OSRAM) |
| EP (1) | EP4346812A4 (OSRAM) |
| JP (1) | JP2024521878A (OSRAM) |
| KR (1) | KR20240017004A (OSRAM) |
| CN (1) | CN120081822A (OSRAM) |
| AU (1) | AU2022283903A1 (OSRAM) |
| BR (1) | BR112023025235A2 (OSRAM) |
| CA (1) | CA3222144A1 (OSRAM) |
| CL (1) | CL2023003591A1 (OSRAM) |
| CO (1) | CO2023016557A2 (OSRAM) |
| CR (1) | CR20230564A (OSRAM) |
| DO (1) | DOP2023000263A (OSRAM) |
| EC (1) | ECSP23090260A (OSRAM) |
| IL (1) | IL308835A (OSRAM) |
| JO (1) | JOP20230315A1 (OSRAM) |
| MX (1) | MX2023014274A (OSRAM) |
| PE (1) | PE20250114A1 (OSRAM) |
| PH (1) | PH12023553130A1 (OSRAM) |
| WO (1) | WO2022256586A2 (OSRAM) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20230286947A1 (en) * | 2020-08-07 | 2023-09-14 | Shanghai Meiyue Biotech Development Co. Ltd | Complement factor b inhibitor, and pharmaceutical composition, preparation method and use thereof |
| JP7641388B2 (ja) * | 2020-12-30 | 2025-03-06 | エス－インフィニティ ファーマシューティカルズ カンパニー リミテッド | 一連のピペリジン置換安息香酸系化合物及びその使用 |
| EP4362933A4 (en) * | 2021-06-30 | 2025-06-04 | Apellis Pharmaceuticals, Inc. | COMPLEMENT INHIBITION |
| CA3229360A1 (en) | 2021-08-18 | 2023-02-23 | Chen Zhang | Benzo nitrogen-containing heteroaromatic ring derivative and use thereof in medicine |
| EP4423076A4 (en) * | 2021-10-27 | 2026-01-07 | Hansoh Bio Llc | PIPERIDINYL INDOLE DERIVATIVES, THEIR PREPARATION PROCESSES AND MEDICAL USES |
| CR20240300A (es) * | 2022-01-24 | 2024-08-23 | Novartis Ag | Derivados espirocíclicos de piperidinilo como inhibidores del factor b del complemento y usos de los mismos. |
| CN119301114A (zh) * | 2022-06-07 | 2025-01-10 | 正大天晴药业集团股份有限公司 | 双环取代的芳香羧酸类氘代化合物 |
| WO2023246677A1 (zh) * | 2022-06-20 | 2023-12-28 | 深圳信立泰药业股份有限公司 | 一种吲哚-苯基哌啶化合物及其制备方法与应用 |
| CN119546585A (zh) * | 2022-06-23 | 2025-02-28 | 上海济煜医药科技有限公司 | 吲哚化合物的制备、应用及用途 |
| WO2024049977A1 (en) * | 2022-08-31 | 2024-03-07 | Chinook Therapeutics, Inc. | Substituted indole compounds and methods of use thereof |
| JP2025530222A (ja) * | 2022-09-10 | 2025-09-11 | 江▲蘇▼豪森▲薬▼▲業▼集▲団▼有限公司 | ２－置換ピペリジン誘導体、その製造方法及び医薬的用途 |
| KR20250107882A (ko) * | 2022-11-14 | 2025-07-14 | 노파르티스 파르마 아게 | 보체 인자 b 억제제의 고체 형태 |
| TWI869080B (zh) * | 2022-11-29 | 2025-01-01 | 大陸商上海濟煜醫藥科技有限公司 | 苯並螺環吲哚化合物的製備及用途 |
| WO2024148274A1 (en) * | 2023-01-05 | 2024-07-11 | Apellis Pharmaceuticals, Inc. | Complement inhibition |
| EP4650351A1 (en) * | 2023-01-09 | 2025-11-19 | Nanjing Chia Tai Tianqing Pharmaceutical Co., Ltd. | Inhibitor of complement factor b |
| AU2024221845A1 (en) * | 2023-02-16 | 2025-09-11 | Haisco Pharmaceutical Group Co., Ltd. | Salt of benzo-nitrogen heteroaromatic ring derivative, crystalline form, and pharmaceutical use thereof |
| EP4670719A1 (en) * | 2023-02-22 | 2025-12-31 | Haisco Pharmaceutical Group Co., Ltd. | PHARMACEUTICAL COMPOSITION OF A HETEROAROMATIC BENZO-NITROGEN RING DERIVATIVE AND ITS USE IN MEDICINE |
| WO2024222852A1 (zh) * | 2023-04-27 | 2024-10-31 | 上海翰森生物医药科技有限公司 | 一种哌啶基吲哚化合物的盐及其制备方法 |
| WO2025008451A1 (en) | 2023-07-04 | 2025-01-09 | Sitala Bio Ltd | 2-(1h-indol-4-yl)methyl)2h-indazole derivatives as factor b inhibitors |
| AU2024290587A1 (en) | 2023-07-04 | 2026-02-19 | Sitala Bio Ltd | 2-(1h-indol-4-yl)methyl)-isoindoline derivatives as factor b inhibitors |
| EP4739667A2 (en) | 2023-07-06 | 2026-05-13 | Sitala Bio Ltd | Indole derivatives with factor b inhibitory activity |
| WO2025008517A1 (en) | 2023-07-06 | 2025-01-09 | Sitala Bio Ltd | Indole derivatives with factor b inhibitory activity |
| TWI896250B (zh) * | 2023-07-26 | 2025-09-01 | 大陸商上海美悦生物科技發展有限公司 | 螺環烯基類或氮雜烯基類化合物及其藥物組合物、製備方法和用途 |
| TW202517258A (zh) * | 2023-09-20 | 2025-05-01 | 大陸商上海美悦生物科技發展有限公司 | 雜環化合物在製備預防和／或治療腎臟疾病的藥物中的用途 |
| TW202535375A (zh) * | 2023-12-05 | 2025-09-16 | 大陸商西藏海思科製藥有限公司 | 苯並氮雜芳環衍生物在治療補體因數b介導的疾病中的用途 |
| WO2025172535A1 (en) | 2024-02-15 | 2025-08-21 | Sitala Bio Ltd | Indole and benzimidazole compounds as factor b inhibitors |
| WO2025256647A1 (zh) * | 2024-06-14 | 2025-12-18 | 润尔眼科药物（广州）有限公司 | 化合物及其医药用途 |
| WO2026008073A1 (zh) * | 2024-07-05 | 2026-01-08 | 南京正大天晴制药有限公司 | 补体因子b抑制剂的剂量组合物 |
| WO2026069246A1 (en) * | 2024-09-30 | 2026-04-02 | Novartis Ag | Complement factor b inhibitors and uses thereof |
| CN121949280A (zh) * | 2024-10-31 | 2026-05-01 | 甫康（上海）健康科技有限责任公司 | 一种多取代吲哚类化合物及其制备方法和用途 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6180514B2 (ja) * | 2012-05-04 | 2017-08-16 | ノバルティス アーゲー | 補体経路モジュレーターおよびその使用 |
| EP2867225B1 (en) * | 2012-06-28 | 2017-08-09 | Novartis AG | Pyrrolidine derivatives and their use as complement pathway modulators |
| JO3425B1 (ar) * | 2013-07-15 | 2019-10-20 | Novartis Ag | مشتقات البابيريدينيل-اندول واستخدامها كعامل متمم لمثبطات b |
| CN109414441A (zh) * | 2016-06-27 | 2019-03-01 | 艾其林医药公司 | 治疗医学障碍的喹唑啉和吲哚化合物 |
| US20230286947A1 (en) | 2020-08-07 | 2023-09-14 | Shanghai Meiyue Biotech Development Co. Ltd | Complement factor b inhibitor, and pharmaceutical composition, preparation method and use thereof |
| TW202313579A (zh) | 2021-06-03 | 2023-04-01 | 瑞典商艾爾比瑞歐公司 | 苯并噻(二)氮呯(benzothia(di)azepine)化合物及其作為膽酸調節劑之用途 |
| CR20230614A (es) | 2021-06-03 | 2024-02-01 | Novartis Ag | Derivados de 3-(1-oxoisoindolin-2-il)piperidina-2,6-diona y sus usos médicos |
| US20240294517A1 (en) | 2021-06-24 | 2024-09-05 | Syngenta Crop Protection Ag | 2-[3-[1 [(quinazolin-4-yl)amino]ethyl]pyrazin-2-yl]thiazole-5-carbonitrile derivatives and similar compounds as pesticides |
| CA3224494A1 (en) | 2021-07-09 | 2023-01-12 | Koen Vandyck | Anti-viral compounds |
| CA3226387A1 (en) | 2021-07-26 | 2023-02-02 | Joel D. Moore | Rock2 inhibitors and uses thereof |
| EP4423076A4 (en) * | 2021-10-27 | 2026-01-07 | Hansoh Bio Llc | PIPERIDINYL INDOLE DERIVATIVES, THEIR PREPARATION PROCESSES AND MEDICAL USES |
| AR127922A1 (es) | 2021-12-15 | 2024-03-13 | Syngenta Crop Protection Ag | Derivados heterocíclicos bicíclicos microbiocidas |
| US20250326757A1 (en) | 2022-05-26 | 2025-10-23 | Astrazeneca Ab | Solid forms of heterocyclylamides as irak4 inhibitors |
-
2022
- 2022-06-03 MX MX2023014274A patent/MX2023014274A/es unknown
- 2022-06-03 JP JP2023574119A patent/JP2024521878A/ja active Pending
- 2022-06-03 BR BR112023025235A patent/BR112023025235A2/pt unknown
- 2022-06-03 PE PE2023003178A patent/PE20250114A1/es unknown
- 2022-06-03 CR CR20230564A patent/CR20230564A/es unknown
- 2022-06-03 WO PCT/US2022/032042 patent/WO2022256586A2/en not_active Ceased
- 2022-06-03 IL IL308835A patent/IL308835A/en unknown
- 2022-06-03 KR KR1020237045081A patent/KR20240017004A/ko active Pending
- 2022-06-03 PH PH1/2023/553130A patent/PH12023553130A1/en unknown
- 2022-06-03 CN CN202510248844.6A patent/CN120081822A/zh active Pending
- 2022-06-03 US US18/566,259 patent/US20240287034A1/en active Pending
- 2022-06-03 AU AU2022283903A patent/AU2022283903A1/en active Pending
- 2022-06-03 CA CA3222144A patent/CA3222144A1/en active Pending
- 2022-06-03 EP EP22816892.8A patent/EP4346812A4/en active Pending
-
2023
- 2023-11-30 CL CL2023003591A patent/CL2023003591A1/es unknown
- 2023-11-30 JO JOJO/P/2023/0315A patent/JOP20230315A1/ar unknown
- 2023-11-30 EC ECSENADI202390260A patent/ECSP23090260A/es unknown
- 2023-11-30 CO CONC2023/0016557A patent/CO2023016557A2/es unknown
- 2023-11-30 DO DO2023000263A patent/DOP2023000263A/es unknown
-
2025
- 2025-05-30 US US19/223,498 patent/US12617774B2/en active Active
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