JP2024520188A5 - - Google Patents

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Publication number
JP2024520188A5
JP2024520188A5 JP2023561035A JP2023561035A JP2024520188A5 JP 2024520188 A5 JP2024520188 A5 JP 2024520188A5 JP 2023561035 A JP2023561035 A JP 2023561035A JP 2023561035 A JP2023561035 A JP 2023561035A JP 2024520188 A5 JP2024520188 A5 JP 2024520188A5
Authority
JP
Japan
Prior art keywords
seq
amino acid
acid sequence
cdr
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2023561035A
Other languages
English (en)
Japanese (ja)
Other versions
JP2024520188A (ja
JP7579990B2 (ja
Filing date
Publication date
Priority claimed from EP21170941.5A external-priority patent/EP4066899A1/en
Priority claimed from EP21172723.5A external-priority patent/EP4086284A1/en
Application filed filed Critical
Priority claimed from PCT/EP2022/058626 external-priority patent/WO2022207822A1/en
Publication of JP2024520188A publication Critical patent/JP2024520188A/ja
Publication of JP2024520188A5 publication Critical patent/JP2024520188A5/ja
Application granted granted Critical
Publication of JP7579990B2 publication Critical patent/JP7579990B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2023561035A 2021-03-31 2022-03-31 抗ネクチン－４抗体およびその使用 Active JP7579990B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP21166441.2 2021-03-31
EP21166441 2021-03-31
EP21170941.5 2021-04-28
EP21170941.5A EP4066899A1 (en) 2021-03-31 2021-04-28 Anti-nectin-4 antibody
EP21172723.5 2021-05-07
EP21172723.5A EP4086284A1 (en) 2021-05-07 2021-05-07 Anti-nectin-4 antibody exatecan conjugates
EP21209332 2021-11-19
EP21209332.2 2021-11-19
PCT/EP2022/058626 WO2022207822A1 (en) 2021-03-31 2022-03-31 Anti-nectin-4-antibodies and uses thereof

Publications (3)

Publication Number Publication Date
JP2024520188A JP2024520188A (ja) 2024-05-22
JP2024520188A5 true JP2024520188A5 (https=) 2024-08-13
JP7579990B2 JP7579990B2 (ja) 2024-11-08

Family

ID=80999114

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2023561116A Active JP7579991B2 (ja) 2021-03-31 2022-03-31 抗ネクチン－４抗体エキサテカンコンジュゲート
JP2023561035A Active JP7579990B2 (ja) 2021-03-31 2022-03-31 抗ネクチン－４抗体およびその使用

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2023561116A Active JP7579991B2 (ja) 2021-03-31 2022-03-31 抗ネクチン－４抗体エキサテカンコンジュゲート

Country Status (18)

Country Link
US (4) US20240181075A1 (https=)
EP (2) EP4314057A1 (https=)
JP (2) JP7579991B2 (https=)
KR (2) KR20240035378A (https=)
AU (2) AU2022248735A1 (https=)
BR (1) BR112023017728A2 (https=)
CA (2) CA3212651A1 (https=)
CL (2) CL2023002909A1 (https=)
CO (2) CO2023012821A2 (https=)
CR (2) CR20230470A (https=)
DO (2) DOP2023000213A (https=)
EC (2) ECSP23073625A (https=)
IL (2) IL305951A (https=)
JO (2) JOP20230239A1 (https=)
MX (2) MX2023011563A (https=)
PE (2) PE20240724A1 (https=)
SA (1) SA523450918B1 (https=)
WO (3) WO2022207828A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4285935A1 (en) * 2022-06-03 2023-12-06 Emergence Therapeutics AG Novel anti-nectin-4 antibody camptothecin derivative conjugates
EP4309676A1 (en) * 2022-07-22 2024-01-24 Emergence Therapeutics AG Novel anti-nectin-4 antibody camptothecin derivative conjugates
EP4344707A1 (en) * 2022-09-29 2024-04-03 Emergence Therapeutics AG New anti-nectin-4 antibody drug conjugates
EP4461317A1 (en) * 2023-05-12 2024-11-13 Emergence Therapeutics GmbH Antibody-drug conjugates comprising an anti-nectin-4 antibody and belotecan or a derivative thereof
WO2024251260A1 (zh) * 2023-06-08 2024-12-12 江苏迈威康新药研发有限公司 结合Nectin-4的抗体及其用途
JP7689606B2 (ja) * 2023-06-20 2025-06-06 イーライ リリー アンド カンパニー ネクチン－４抗体及び抗体－薬物コンジュゲート
EP4534101A1 (en) 2023-10-02 2025-04-09 Eli Lilly and Company Antibody drug conjugate (adc) targeting nectin 4 and comprising an exatecan payload
EP4534102A1 (en) 2023-10-02 2025-04-09 Eli Lilly and Company Antibody drug conjugate (adc) targeting nectin 4 and comprising an exatecan payload

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX347954B (es) 2010-09-29 2017-05-19 Agensys Inc Conjugados de anticuerpo farmaco (adc) que enlazan a proteinas 191p4d12.
EP3347048B1 (en) * 2015-09-09 2020-04-01 INSERM (Institut National de la Santé et de la Recherche Médicale) Antibodies having specificity to nectin-4 and uses thereof
CA3044898C (en) * 2016-11-25 2022-04-05 Mabwell (shanghai) Bioscience Co., Ltd. Di-substituted maleic amide linker for antibody-drug conjugating and preparation method and use thereof
CN110392697A (zh) 2017-03-02 2019-10-29 国家医疗保健研究所 对nectin-4具有特异性的抗体及其用途
JP7381478B2 (ja) * 2017-10-23 2023-11-15 マブリンク ビオシオンス 単一分子量ポリサルコシンを含むリガンド－薬物－複合体
NZ781538A (en) * 2019-04-24 2025-12-19 Heidelberg Pharma Res Gmbh Amatoxin antibody-drug conjugates and uses thereof
US12398206B2 (en) * 2019-10-07 2025-08-26 Université D'aixmarseille Antibodies having specificity for nectin-4 and uses thereof
WO2021143741A1 (zh) * 2020-01-15 2021-07-22 北京海步医药科技有限公司 靶向多肽-药物缀合物及其用途
EP4096717B1 (en) * 2020-01-31 2024-12-11 Innate Pharma Treatment of cancer

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