JP2024519082A - 肝細胞がんのｄｎａメチル化バイオマーカー - Google Patents
肝細胞がんのｄｎａメチル化バイオマーカー Download PDFInfo
- Publication number
- JP2024519082A JP2024519082A JP2023571830A JP2023571830A JP2024519082A JP 2024519082 A JP2024519082 A JP 2024519082A JP 2023571830 A JP2023571830 A JP 2023571830A JP 2023571830 A JP2023571830 A JP 2023571830A JP 2024519082 A JP2024519082 A JP 2024519082A
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- JP
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- Prior art keywords
- cancer
- methylation
- dmr
- patient
- samples
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/20—Supervised data analysis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Evolutionary Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Theoretical Computer Science (AREA)
- Data Mining & Analysis (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Databases & Information Systems (AREA)
- Software Systems (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Bioethics (AREA)
- Artificial Intelligence (AREA)
- Evolutionary Computation (AREA)
- Public Health (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP21175425 | 2021-05-21 | ||
| EP21175425.4 | 2021-05-21 | ||
| PCT/EP2022/063902 WO2022243566A1 (en) | 2021-05-21 | 2022-05-23 | Dna methylation biomarkers for hepatocellular carcinoma |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024519082A true JP2024519082A (ja) | 2024-05-08 |
| JP2024519082A5 JP2024519082A5 (https=) | 2025-05-21 |
Family
ID=76059821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023571830A Pending JP2024519082A (ja) | 2021-05-21 | 2022-05-23 | 肝細胞がんのｄｎａメチル化バイオマーカー |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20240229158A1 (https=) |
| EP (1) | EP4341441A1 (https=) |
| JP (1) | JP2024519082A (https=) |
| CN (1) | CN117355616A (https=) |
| WO (1) | WO2022243566A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN120584199A (zh) * | 2023-01-26 | 2025-09-02 | 乐彼代株式会社 | 用于预测发展肝癌风险的组合物 |
| TWI911076B (zh) * | 2024-04-22 | 2026-01-01 | 雲享投資顧問有限公司 | 早期肝細胞癌的檢測方法及在該方法中使用的試劑套組 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9984201B2 (en) | 2015-01-18 | 2018-05-29 | Youhealth Biotech, Limited | Method and system for determining cancer status |
| WO2017048932A1 (en) | 2015-09-17 | 2017-03-23 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Cancer detection methods |
| CN113151458A (zh) | 2016-07-06 | 2021-07-23 | 优美佳肿瘤技术有限公司 | 实体瘤甲基化标志物及其用途 |
| WO2018009705A1 (en) | 2016-07-06 | 2018-01-11 | Youhealth Biotech, Limited | Liver cancer methylation markers and uses thereof |
| EP3507298B1 (en) * | 2016-09-02 | 2023-08-30 | Mayo Foundation for Medical Education and Research | Detecting hepatocellular carcinoma |
| BR112019018272A2 (pt) * | 2017-03-02 | 2020-07-28 | Youhealth Oncotech, Limited | marcadores metilação para diagnosticar hepatocelular carcinoma e câncer |
| KR102103885B1 (ko) | 2019-10-08 | 2020-04-24 | 주식회사 레피다인 | 생물학적 시료의 간 조직 유래 여부를 판별하는 방법 |
| CN112037863B (zh) * | 2020-08-26 | 2022-06-21 | 南京医科大学 | 一种早期nsclc预后预测系统 |
-
2022
- 2022-05-23 CN CN202280036799.2A patent/CN117355616A/zh active Pending
- 2022-05-23 JP JP2023571830A patent/JP2024519082A/ja active Pending
- 2022-05-23 WO PCT/EP2022/063902 patent/WO2022243566A1/en not_active Ceased
- 2022-05-23 US US18/562,839 patent/US20240229158A1/en active Pending
- 2022-05-23 EP EP22728633.3A patent/EP4341441A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022243566A1 (en) | 2022-11-24 |
| CN117355616A (zh) | 2024-01-05 |
| EP4341441A1 (en) | 2024-03-27 |
| US20240229158A1 (en) | 2024-07-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20250513 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20250513 |