CN117355616A - 用于肝细胞癌的dna甲基化生物标志物 - Google Patents

用于肝细胞癌的dna甲基化生物标志物 Download PDF

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Publication number
CN117355616A
CN117355616A CN202280036799.2A CN202280036799A CN117355616A CN 117355616 A CN117355616 A CN 117355616A CN 202280036799 A CN202280036799 A CN 202280036799A CN 117355616 A CN117355616 A CN 117355616A
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Prior art keywords
cancer
dmr
methylation
patient
samples
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Pending
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CN202280036799.2A
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English (en)
Chinese (zh)
Inventor
荷西·佩雷拉·利尔
乔安娜·卡多索·瓦兹
伊曼纽尔·荷西·维埃拉·冈萨雷斯
玛丽亚·安娜·冈萨雷斯·里斯
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Ofer Ormix Biotechnology Research & Development Ag
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Ofer Ormix Biotechnology Research & Development Ag
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Publication of CN117355616A publication Critical patent/CN117355616A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Evolutionary Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Theoretical Computer Science (AREA)
  • Data Mining & Analysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Databases & Information Systems (AREA)
  • Software Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Bioethics (AREA)
  • Artificial Intelligence (AREA)
  • Evolutionary Computation (AREA)
  • Public Health (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN202280036799.2A 2021-05-21 2022-05-23 用于肝细胞癌的dna甲基化生物标志物 Pending CN117355616A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP21175425 2021-05-21
EP21175425.4 2021-05-21
PCT/EP2022/063902 WO2022243566A1 (en) 2021-05-21 2022-05-23 Dna methylation biomarkers for hepatocellular carcinoma

Publications (1)

Publication Number Publication Date
CN117355616A true CN117355616A (zh) 2024-01-05

Family

ID=76059821

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202280036799.2A Pending CN117355616A (zh) 2021-05-21 2022-05-23 用于肝细胞癌的dna甲基化生物标志物

Country Status (5)

Country Link
US (1) US20240229158A1 (https=)
EP (1) EP4341441A1 (https=)
JP (1) JP2024519082A (https=)
CN (1) CN117355616A (https=)
WO (1) WO2022243566A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI911076B (zh) * 2024-04-22 2026-01-01 雲享投資顧問有限公司 早期肝細胞癌的檢測方法及在該方法中使用的試劑套組

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN120584199A (zh) * 2023-01-26 2025-09-02 乐彼代株式会社 用于预测发展肝癌风险的组合物

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9984201B2 (en) 2015-01-18 2018-05-29 Youhealth Biotech, Limited Method and system for determining cancer status
WO2017048932A1 (en) 2015-09-17 2017-03-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cancer detection methods
CN113151458A (zh) 2016-07-06 2021-07-23 优美佳肿瘤技术有限公司 实体瘤甲基化标志物及其用途
WO2018009705A1 (en) 2016-07-06 2018-01-11 Youhealth Biotech, Limited Liver cancer methylation markers and uses thereof
EP3507298B1 (en) * 2016-09-02 2023-08-30 Mayo Foundation for Medical Education and Research Detecting hepatocellular carcinoma
BR112019018272A2 (pt) * 2017-03-02 2020-07-28 Youhealth Oncotech, Limited marcadores metilação para diagnosticar hepatocelular carcinoma e câncer
KR102103885B1 (ko) 2019-10-08 2020-04-24 주식회사 레피다인 생물학적 시료의 간 조직 유래 여부를 판별하는 방법
CN112037863B (zh) * 2020-08-26 2022-06-21 南京医科大学 一种早期nsclc预后预测系统

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI911076B (zh) * 2024-04-22 2026-01-01 雲享投資顧問有限公司 早期肝細胞癌的檢測方法及在該方法中使用的試劑套組

Also Published As

Publication number Publication date
WO2022243566A1 (en) 2022-11-24
EP4341441A1 (en) 2024-03-27
JP2024519082A (ja) 2024-05-08
US20240229158A1 (en) 2024-07-11

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