JP2024516826A - 嚢胞性線維症を治療するためのある特定のｎ－（１－シアノ－２－フェニルエチル）－１，４－オキサゼパン－２－カルボキサミド - Google Patents
嚢胞性線維症を治療するためのある特定のｎ－（１－シアノ－２－フェニルエチル）－１，４－オキサゼパン－２－カルボキサミド Download PDFInfo
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- oxazepane
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
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- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
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- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
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- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Biophysics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163181817P | 2021-04-29 | 2021-04-29 | |
| US63/181,817 | 2021-04-29 | ||
| PCT/US2022/027026 WO2022232573A1 (en) | 2021-04-29 | 2022-04-29 | Certain n-(1-cyano-2-phenylethyl)-1,4-oxazepane-2-carboxamides for treating cystic fibrosis |
Publications (3)
| Publication Number | Publication Date |
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| JP2024516826A true JP2024516826A (ja) | 2024-04-17 |
| JP2024516826A5 JP2024516826A5 (https=) | 2025-05-09 |
| JPWO2022232573A5 JPWO2022232573A5 (https=) | 2025-05-09 |
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| JP2023566480A Pending JP2024516826A (ja) | 2021-04-29 | 2022-04-29 | 嚢胞性線維症を治療するためのある特定のｎ－（１－シアノ－２－フェニルエチル）－１，４－オキサゼパン－２－カルボキサミド |
Country Status (6)
| Country | Link |
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| US (1) | US20240226112A1 (https=) |
| EP (1) | EP4329767A4 (https=) |
| JP (1) | JP2024516826A (https=) |
| KR (1) | KR20240004691A (https=) |
| CA (1) | CA3215375A1 (https=) |
| WO (1) | WO2022232573A1 (https=) |
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| NO2699580T3 (https=) | 2014-01-24 | 2018-02-24 | ||
| KR20250002710A (ko) | 2018-03-01 | 2025-01-07 | 아스트라제네카 에이비이 | (2s)-n-｛(1s)-1-시아노-2-[4-(3-메틸-2-옥소-2,3-디하이드로-1,3-벤족사졸-5-일)페닐]에틸｝-1,4-옥사제판-2-카복스아미드를포함하는 약학 조성물 |
| AU2019306532A1 (en) | 2018-07-17 | 2021-03-04 | Insmed Incorporated | Certain (2S)-N-[(1S)-1-cyano-2-phenylethyl]-1,4-oxazepane-2-carboxamides for treating Lupus Nephritis |
| EP4646265A1 (en) | 2023-01-06 | 2025-11-12 | Insmed Incorporated | Novel, reversible dpp1 inhibitors and uses thereof |
| JP2026510407A (ja) * | 2023-03-23 | 2026-04-02 | ハイスコ ファーマスーティカル プライベート リミテッド | ジペプチジルペプチダーゼ小分子阻害剤を含む医薬組成物 |
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| WO2004076434A1 (en) * | 2003-02-28 | 2004-09-10 | Aic | Dipeptidyl peptidase inhibitors |
| PE20151727A1 (es) * | 2013-03-14 | 2015-12-17 | Boehringer Ingelheim Int | Acido 2-aza-biciclo[2.2.1]heptano-3-carboxilico (bencil-ciano-metil)-amidas sustituidas inhibidores de catepsina c |
| NO2699580T3 (https=) * | 2014-01-24 | 2018-02-24 | ||
| DK3265452T3 (en) * | 2015-03-05 | 2020-06-08 | Neuprozyme Therapeutics ApS | Peptidyl nitril compounds as dipeptidyl peptidase i inhibitors |
| KR20250107292A (ko) * | 2016-07-29 | 2025-07-11 | 인스메드 인코포레이티드 | 기관지확장증을 치료하기 위한 특정 (2s)-n-[(1s)-1-시아노-2-페닐에틸]-1,4-옥사제판-2-카르복스아미드 |
| KR20250002710A (ko) * | 2018-03-01 | 2025-01-07 | 아스트라제네카 에이비이 | (2s)-n-｛(1s)-1-시아노-2-[4-(3-메틸-2-옥소-2,3-디하이드로-1,3-벤족사졸-5-일)페닐]에틸｝-1,4-옥사제판-2-카복스아미드를포함하는 약학 조성물 |
-
2022
- 2022-04-29 US US18/288,338 patent/US20240226112A1/en active Pending
- 2022-04-29 JP JP2023566480A patent/JP2024516826A/ja active Pending
- 2022-04-29 CA CA3215375A patent/CA3215375A1/en active Pending
- 2022-04-29 WO PCT/US2022/027026 patent/WO2022232573A1/en not_active Ceased
- 2022-04-29 EP EP22796849.2A patent/EP4329767A4/en not_active Withdrawn
- 2022-04-29 KR KR1020237040988A patent/KR20240004691A/ko active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2022232573A1 (en) | 2022-11-03 |
| CA3215375A1 (en) | 2022-11-03 |
| KR20240004691A (ko) | 2024-01-11 |
| EP4329767A4 (en) | 2025-03-12 |
| US20240226112A1 (en) | 2024-07-11 |
| EP4329767A1 (en) | 2024-03-06 |
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