JP2024515919A5 - - Google Patents

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Publication number
JP2024515919A5
JP2024515919A5 JP2023540515A JP2023540515A JP2024515919A5 JP 2024515919 A5 JP2024515919 A5 JP 2024515919A5 JP 2023540515 A JP2023540515 A JP 2023540515A JP 2023540515 A JP2023540515 A JP 2023540515A JP 2024515919 A5 JP2024515919 A5 JP 2024515919A5
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JP
Japan
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domain
car
cd3ζ
dap10
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JP2023540515A
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English (en)
Japanese (ja)
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JP7707304B2 (ja
JP2024515919A (ja
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Priority claimed from PCT/US2023/065537 external-priority patent/WO2023196982A1/en
Publication of JP2024515919A publication Critical patent/JP2024515919A/ja
Publication of JP2024515919A5 publication Critical patent/JP2024515919A5/ja
Application granted granted Critical
Publication of JP7707304B2 publication Critical patent/JP7707304B2/ja
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JP2023540515A 2022-04-08 2023-04-07 腫瘍標的化のためのキメラ抗原受容体 Active JP7707304B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202263329287P 2022-04-08 2022-04-08
US63/329,287 2022-04-08
PCT/US2023/065537 WO2023196982A1 (en) 2022-04-08 2023-04-07 Chimeric antigen receptor for tumor targeting

Publications (3)

Publication Number Publication Date
JP2024515919A JP2024515919A (ja) 2024-04-11
JP2024515919A5 true JP2024515919A5 (enExample) 2024-08-15
JP7707304B2 JP7707304B2 (ja) 2025-07-14

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ID=88243837

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JP2023540515A Active JP7707304B2 (ja) 2022-04-08 2023-04-07 腫瘍標的化のためのキメラ抗原受容体

Country Status (11)

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US (2) US20250222029A1 (enExample)
EP (1) EP4504799A4 (enExample)
JP (1) JP7707304B2 (enExample)
KR (1) KR20250004622A (enExample)
CN (1) CN118871471A (enExample)
AU (1) AU2023248529A1 (enExample)
CA (1) CA3247010A1 (enExample)
IL (1) IL316102A (enExample)
MX (1) MX2024010924A (enExample)
TW (1) TW202440620A (enExample)
WO (1) WO2023196982A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW202229359A (zh) * 2020-11-30 2022-08-01 日商小野藥品工業股份有限公司 Her2標靶藥物
JP7707304B2 (ja) 2022-04-08 2025-07-14 フェイト セラピューティクス,インコーポレイティド 腫瘍標的化のためのキメラ抗原受容体
KR20250005097A (ko) * 2022-04-08 2025-01-09 페이트 세러퓨틱스, 인코포레이티드 고형 종양 표적화 골격을 갖는 세포 및 이의 용도

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
GB9710809D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
GB9710807D0 (en) 1997-05-23 1997-07-23 Medical Res Council Nucleic acid binding proteins
US6140081A (en) 1998-10-16 2000-10-31 The Scripps Research Institute Zinc finger binding domains for GNN
US6534261B1 (en) 1999-01-12 2003-03-18 Sangamo Biosciences, Inc. Regulation of endogenous gene expression in cells using zinc finger proteins
US6453242B1 (en) 1999-01-12 2002-09-17 Sangamo Biosciences, Inc. Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
JP2002060786A (ja) 2000-08-23 2002-02-26 Kao Corp 硬質表面用殺菌防汚剤
WO2003016496A2 (en) 2001-08-20 2003-02-27 The Scripps Research Institute Zinc finger binding domains for cnn
US7745140B2 (en) 2002-01-03 2010-06-29 The Trustees Of The University Of Pennsylvania Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
US7972854B2 (en) 2004-02-05 2011-07-05 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
CA2568344C (en) 2004-05-27 2016-01-19 The Trustees Of The University Of Pennsylvania Novel artificial antigen presenting cells and uses therefor
CN105837690A (zh) 2006-06-12 2016-08-10 新兴产品开发西雅图有限公司 具有效应功能的单链多价结合蛋白
NO2510096T3 (enExample) 2009-12-10 2015-03-21
EP3399026B1 (en) 2010-06-14 2024-06-26 The Scripps Research Institute Reprogramming of cells to a new fate
PH12014500247A1 (en) 2011-07-29 2014-03-24 Univ Pennsylvania Switch costimulatory receptors
EP3594245A1 (en) 2012-02-13 2020-01-15 Seattle Children's Hospital d/b/a Seattle Children's Research Institute Bispecific chimeric antigen receptors and therapeutic uses thereof
EP4541818A3 (en) 2012-05-25 2025-07-23 Cellectis Methods for engineering allogeneic and immunosuppressive resistant t cell for immunotherapy
SI3300745T1 (sl) 2013-02-15 2020-01-31 The Regents Of The University Of California Himerni antigenski receptor in postopki njihove uporabe
US9932607B2 (en) 2013-11-15 2018-04-03 The Board Of Trustees Of The Leland Stanford Junior University Site-specific integration of transgenes into human cells
US10934346B2 (en) 2014-02-14 2021-03-02 Bellicum Pharmaceuticals, Inc. Modified T cell comprising a polynucleotide encoding an inducible stimulating molecule comprising MyD88, CD40 and FKBP12
CA3190002A1 (en) 2014-02-14 2015-08-20 Board Of Regents, The University Of Texas System Chimeric antigen receptors and methods of making
SG11201606934SA (en) 2014-03-04 2016-09-29 Fate Therapeutics Inc Improved reprogramming methods and cell culture platforms
US20170158749A1 (en) * 2014-04-23 2017-06-08 Board Of Regents, The University Of Texas System Chimeric antigen receptors (car) and methods for making and using the same
CA2959168A1 (en) 2014-09-02 2016-03-10 Bellicum Pharmaceuticals, Inc. Costimulation of chimeric antigen receptors by myd88 and cd40 polypeptides
US11161907B2 (en) * 2015-02-02 2021-11-02 Novartis Ag Car-expressing cells against multiple tumor antigens and uses thereof
EP3271463A4 (en) 2015-03-18 2018-08-01 Baylor College of Medicine Her2/erbb2 chimeric antigen receptor
CA3001917A1 (en) 2015-10-16 2017-04-20 Fate Therapeutics, Inc. Platform for the induction & maintenance of ground state pluripotency
CN108779174B (zh) * 2015-11-04 2022-11-29 希望之城公司 靶向her2的嵌合抗原受体
WO2017078807A1 (en) 2015-11-04 2017-05-11 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
CA3007473A1 (en) 2015-12-14 2017-06-22 Bellicum Pharmaceuticals, Inc. Dual controls for therapeutic cell activation or elimination
EP3405568A4 (en) 2016-01-20 2019-12-04 Fate Therapeutics, Inc. COMPOUNDS AND METHODS FOR IMMUNOCELL MODULATION IN ADOPTIVE IMMUNOTHERAPIES
BR112020007228A2 (pt) 2017-10-11 2020-10-13 Fate Therapeutics, Inc. reprogramação celular usando sistema de expressão de vetor plasmídeo temporal e transitório
US11649294B2 (en) * 2017-11-14 2023-05-16 GC Cell Corporation Anti-HER2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same
EP3712178A4 (en) 2017-11-14 2021-08-11 Green Cross Lab Cell Corporation ANTI-HER2 ANTIBODIES OR ANTIGIBODY FRAGMENT THEREOF AND CHIMERAIR ANTIGEN RECEPTOR WITH IT
BR112020010597A2 (pt) 2017-12-08 2020-10-27 Fate Therapeutics, Inc. imunoterapias com o uso de células efetoras derivadas de ipsc intensificadas
KR20250048610A (ko) 2017-12-22 2025-04-09 페이트 세러퓨틱스, 인코포레이티드 향상된 면역 효과기 세포 및 이의 용도
SG10201801219VA (en) * 2018-02-13 2019-09-27 Agency Science Tech & Res Anti-HER2 Antibodies
WO2019191495A1 (en) 2018-03-29 2019-10-03 Fate Therapeutics, Inc. Engineered immune effector cells and use thereof
US20210308183A1 (en) 2018-07-17 2021-10-07 The Regents Of The University Of California Chimeric antigen receptor t cells derived from immunoengineered pluripotent stem cells
US20210388389A1 (en) 2018-10-30 2021-12-16 Yale University Compositions and methods for rapid and modular generation of chimeric antigen receptor t cells
CA3133419A1 (en) 2019-03-21 2020-09-24 Gamida Cell Ltd. Expansion and use of expanded nk cell fractions suitable for transplantation in combination therapy
JP7727549B2 (ja) * 2019-03-22 2025-08-21 セルティス・セラピューティクス・ピーティーワイ・リミテッド 抗her2結合分子
CA3146967A1 (en) 2019-07-17 2021-01-21 Fate Therapeutics, Inc. Immune effector cell engineering and use thereof
JP2022548943A (ja) 2019-09-25 2022-11-22 フェイト セラピューティクス,インコーポレイテッド 複数標的化エフェクター細胞およびその使用
IL291924A (en) 2019-10-07 2022-06-01 Fate Therapeutics Inc Enhanced chimeric antigen receptor for immune effector cell engineering and use thereof
JP7664913B2 (ja) 2019-10-17 2025-04-18 フェイト セラピューティクス,インコーポレイテッド 免疫のための増強されたキメラ抗原受容体エフェクター細胞操作およびその使用
MX2022006725A (es) 2019-12-06 2022-08-22 Fate Therapeutics Inc Mejora de célula inmunitaria efectora derivada de ipsc mediante el uso de compuestos pequeños.
JP7737996B2 (ja) 2020-01-23 2025-09-11 エクスマ バイオテック コーポレイション Her2に対するキメラ抗原受容体およびその使用方法
CA3184449A1 (en) 2020-05-22 2021-11-25 GC Cell Corporation Anti-her2 antibody or antigen-binding fragment thereof, and chimeric antigen receptor comprising same
US20230390337A1 (en) 2020-11-04 2023-12-07 Fate Therapeutics, Inc. Engineered ipsc and persistent immune effector cells
WO2022098925A1 (en) 2020-11-04 2022-05-12 Fate Therapeutics, Inc. Engineered ipsc and immune effector cells for heterogenous tumor control
CN112391414A (zh) 2020-11-17 2021-02-23 中国医学科学院基础医学研究所 一种靶向her2的car-t表达载体及其构建和应用
TW202229359A (zh) 2020-11-30 2022-08-01 日商小野藥品工業股份有限公司 Her2標靶藥物
JP7707304B2 (ja) 2022-04-08 2025-07-14 フェイト セラピューティクス,インコーポレイティド 腫瘍標的化のためのキメラ抗原受容体

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