JP2024514203A - Ｃｄ５陽性がんを標的とするキメラ抗原受容体 - Google Patents

Ｃｄ５陽性がんを標的とするキメラ抗原受容体 Download PDF

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JP2024514203A
JP2024514203A JP2023563211A JP2023563211A JP2024514203A JP 2024514203 A JP2024514203 A JP 2024514203A JP 2023563211 A JP2023563211 A JP 2023563211A JP 2023563211 A JP2023563211 A JP 2023563211A JP 2024514203 A JP2024514203 A JP 2024514203A
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cells
icd
seq
cell
car
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JP2024514203A5 (https=
Inventor
レズヴァニ、ケイティ
シュポール、エリザベス
バサール、ラフェット
ダヘール、メイ
アチャリヤ、スニル
ウプレティ、ナディマ
コルテス、アナ カレン ヌニェス
エンスリー、エミリー
コスタ、ダビド マリン
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University of Texas System
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University of Texas System
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    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/41—Vertebrate antigens
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
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    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • A61K2239/11—Antigen recognition domain
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JP2023563211A 2021-04-14 2022-04-14 Ｃｄ５陽性がんを標的とするキメラ抗原受容体 Pending JP2024514203A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163174990P 2021-04-14 2021-04-14
US63/174,990 2021-04-14
PCT/US2022/024842 WO2022221548A1 (en) 2021-04-14 2022-04-14 Chimeric antigen receptors to target cd5-positive cancers

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JP2024514203A true JP2024514203A (ja) 2024-03-28
JP2024514203A5 JP2024514203A5 (https=) 2025-02-21

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US (1) US20240189357A1 (https=)
EP (1) EP4322992A4 (https=)
JP (1) JP2024514203A (https=)
KR (1) KR20240007911A (https=)
CN (1) CN117480187A (https=)
AU (1) AU2022259658A1 (https=)
BR (1) BR112023021133A2 (https=)
CA (1) CA3216557A1 (https=)
IL (1) IL307408A (https=)
MX (1) MX2023012180A (https=)
WO (1) WO2022221548A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102831183B1 (ko) * 2021-04-29 2025-07-09 한국생명공학연구원 신규한 항-cd5 키메릭 항원 수용체 및 이를 발현하는 면역세포
EP4419128A4 (en) * 2021-10-20 2025-10-01 Univ Texas NK CELL ENGINEERING WITH CAR CONSTRUCTION WITH OPTIMAL SIGNALING
JP2024539129A (ja) * 2021-10-21 2024-10-28 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 増強された代謝適合性を有する治療用免疫細胞の製造方法およびその組成物
WO2024249728A2 (en) * 2023-06-02 2024-12-05 Board Of Regents, The University Of Texas System Selection of cryopreserved cord blood units for the manufacture of natural killer cells with enhanced potency
WO2025038813A1 (en) * 2023-08-16 2025-02-20 Beam Therapeutics Inc. Cd5-binding polypeptides, compositions comprising the same, and methods for use thereof

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017112877A1 (en) * 2015-12-22 2017-06-29 Icell Gene Therapeutics, Llc Chimeric antigen receptors and enhancement of anti-tumor activity
JP2018513692A (ja) * 2015-02-27 2018-05-31 アイセル・ジーン・セラピューティクス・エルエルシー 血液系腫瘍を標的としたキメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法
JP2018522833A (ja) * 2015-06-12 2018-08-16 イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． キメラ抗原受容体（ｃａｒ）コンストラクト、及びｃａｒコンストラクトを発現するｔ細胞（ｃａｒ−ｔ）またはｎｋ細胞（ｃａｒ−ｎｋ）による疾患治療
JP2020505014A (ja) * 2017-01-05 2020-02-20 コリア リサーチ インスティチュート オブ バイオサイエンス アンド バイオテクノロジー 抗コチニンキメラ抗原受容体を発現するナチュラルキラー細胞
JP2020530989A (ja) * 2017-07-25 2020-11-05 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 強化されたキメラ抗原受容体およびその使用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10786549B2 (en) * 2015-04-23 2020-09-29 Baylor College Of Medicine CD5 chimeric antigen receptor for adoptive T cell therapy
US20230159618A1 (en) * 2017-07-25 2023-05-25 Board Of Regents, The University Of Texas System Enhanced chimeric antigen receptors and use thereof

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018513692A (ja) * 2015-02-27 2018-05-31 アイセル・ジーン・セラピューティクス・エルエルシー 血液系腫瘍を標的としたキメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法
JP2018522833A (ja) * 2015-06-12 2018-08-16 イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． キメラ抗原受容体（ｃａｒ）コンストラクト、及びｃａｒコンストラクトを発現するｔ細胞（ｃａｒ−ｔ）またはｎｋ細胞（ｃａｒ−ｎｋ）による疾患治療
WO2017112877A1 (en) * 2015-12-22 2017-06-29 Icell Gene Therapeutics, Llc Chimeric antigen receptors and enhancement of anti-tumor activity
JP2020505014A (ja) * 2017-01-05 2020-02-20 コリア リサーチ インスティチュート オブ バイオサイエンス アンド バイオテクノロジー 抗コチニンキメラ抗原受容体を発現するナチュラルキラー細胞
JP2020530989A (ja) * 2017-07-25 2020-11-05 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 強化されたキメラ抗原受容体およびその使用

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CA3216557A1 (en) 2022-10-20
AU2022259658A1 (en) 2023-11-23
WO2022221548A1 (en) 2022-10-20
CN117480187A (zh) 2024-01-30
KR20240007911A (ko) 2024-01-17
MX2023012180A (es) 2024-01-05
EP4322992A1 (en) 2024-02-21
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