KR20240007911A - Cd5-양성 암을 표적화하기 위한 키메라 항원 수용체 - Google Patents

Cd5-양성 암을 표적화하기 위한 키메라 항원 수용체 Download PDF

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Publication number
KR20240007911A
KR20240007911A KR1020237039102A KR20237039102A KR20240007911A KR 20240007911 A KR20240007911 A KR 20240007911A KR 1020237039102 A KR1020237039102 A KR 1020237039102A KR 20237039102 A KR20237039102 A KR 20237039102A KR 20240007911 A KR20240007911 A KR 20240007911A
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cells
seq
icd
car
cell
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Korean (ko)
Inventor
케이티 레즈바니
엘리자베쓰 슈팔
라페트 바사르
메이 대허
수닐 아카리아
나디마 업레티
코르테스 아나 카렌 누네즈
에밀리 엔슬레이
코스타 데이비드 마르틴
Original Assignee
더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템
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Publication of KR20240007911A publication Critical patent/KR20240007911A/ko
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
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    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
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    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
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    • A61K40/41—Vertebrate antigens
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
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KR1020237039102A 2021-04-14 2022-04-14 Cd5-양성 암을 표적화하기 위한 키메라 항원 수용체 Pending KR20240007911A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163174990P 2021-04-14 2021-04-14
US63/174,990 2021-04-14
PCT/US2022/024842 WO2022221548A1 (en) 2021-04-14 2022-04-14 Chimeric antigen receptors to target cd5-positive cancers

Publications (1)

Publication Number Publication Date
KR20240007911A true KR20240007911A (ko) 2024-01-17

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KR1020237039102A Pending KR20240007911A (ko) 2021-04-14 2022-04-14 Cd5-양성 암을 표적화하기 위한 키메라 항원 수용체

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Country Link
US (1) US20240189357A1 (https=)
EP (1) EP4322992A4 (https=)
JP (1) JP2024514203A (https=)
KR (1) KR20240007911A (https=)
CN (1) CN117480187A (https=)
AU (1) AU2022259658A1 (https=)
BR (1) BR112023021133A2 (https=)
CA (1) CA3216557A1 (https=)
IL (1) IL307408A (https=)
MX (1) MX2023012180A (https=)
WO (1) WO2022221548A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102831183B1 (ko) * 2021-04-29 2025-07-09 한국생명공학연구원 신규한 항-cd5 키메릭 항원 수용체 및 이를 발현하는 면역세포
EP4419128A4 (en) * 2021-10-20 2025-10-01 Univ Texas NK CELL ENGINEERING WITH CAR CONSTRUCTION WITH OPTIMAL SIGNALING
JP2024539129A (ja) * 2021-10-21 2024-10-28 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム 増強された代謝適合性を有する治療用免疫細胞の製造方法およびその組成物
WO2024249728A2 (en) * 2023-06-02 2024-12-05 Board Of Regents, The University Of Texas System Selection of cryopreserved cord blood units for the manufacture of natural killer cells with enhanced potency
WO2025038813A1 (en) * 2023-08-16 2025-02-20 Beam Therapeutics Inc. Cd5-binding polypeptides, compositions comprising the same, and methods for use thereof

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7237449B2 (ja) * 2015-02-27 2023-03-13 アイセル・ジーン・セラピューティクス・エルエルシー 血液系腫瘍を標的としたキメラ抗体受容体（ＣＡＲｓ）の構成およびその使用方法
US10786549B2 (en) * 2015-04-23 2020-09-29 Baylor College Of Medicine CD5 chimeric antigen receptor for adoptive T cell therapy
AU2016274989A1 (en) * 2015-06-12 2017-11-02 Immunomedics, Inc. Disease therapy with chimeric antigen receptor (car) constructs and t cells (car-t) or nk cells (car-nk) expressing car constructs
WO2017112877A1 (en) * 2015-12-22 2017-06-29 Icell Gene Therapeutics, Llc Chimeric antigen receptors and enhancement of anti-tumor activity
EP3567101A4 (en) * 2017-01-05 2020-12-02 Korea Research Institute of Bioscience and Biotechnology NATURAL KILLER CELL EXPRESSING AN ANTI-COTININ CHEMERIC ANTIGEN RECEPTOR
CA3070998A1 (en) * 2017-07-25 2019-01-31 Board Of Regents, The University Of Texas System Enhanced chimeric antigen receptors and use thereof
US20230159618A1 (en) * 2017-07-25 2023-05-25 Board Of Regents, The University Of Texas System Enhanced chimeric antigen receptors and use thereof

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US20240189357A1 (en) 2024-06-13
CA3216557A1 (en) 2022-10-20
AU2022259658A1 (en) 2023-11-23
WO2022221548A1 (en) 2022-10-20
CN117480187A (zh) 2024-01-30
JP2024514203A (ja) 2024-03-28
MX2023012180A (es) 2024-01-05
EP4322992A1 (en) 2024-02-21
BR112023021133A2 (pt) 2023-12-12
EP4322992A4 (en) 2025-06-18
IL307408A (en) 2023-12-01

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