JP2024513957A - 蛍光ヌクレオシドホスフェート - Google Patents

蛍光ヌクレオシドホスフェート Download PDF

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Publication number
JP2024513957A
JP2024513957A JP2023562564A JP2023562564A JP2024513957A JP 2024513957 A JP2024513957 A JP 2024513957A JP 2023562564 A JP2023562564 A JP 2023562564A JP 2023562564 A JP2023562564 A JP 2023562564A JP 2024513957 A JP2024513957 A JP 2024513957A
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Japan
Prior art keywords
compound
formula
salt
physiologically cleavable
precursor
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Pending
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JP2023562564A
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English (en)
Japanese (ja)
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JP2024513957A5 (https=
Inventor
ヴィンテシュ，エリン エスビョルナル
ウィルヘルムソン，マルクス
ファイフェル，パウリーネ
ガリュー，オドレイ
ニルソン，イェスペル
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Stealth Labels Biotech AB
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Stealth Labels Biotech AB
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Application filed by Stealth Labels Biotech AB filed Critical Stealth Labels Biotech AB
Publication of JP2024513957A publication Critical patent/JP2024513957A/ja
Publication of JP2024513957A5 publication Critical patent/JP2024513957A5/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/117—Modifications characterised by incorporating modified base
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
    • C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2023562564A 2021-04-12 2022-04-11 蛍光ヌクレオシドホスフェート Pending JP2024513957A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB2105194.1 2021-04-12
GB2105194.1A GB2605952A (en) 2021-04-12 2021-04-12 Fluorescent nucleoside triphosphates
PCT/EP2022/059666 WO2022218943A1 (en) 2021-04-12 2022-04-11 Fluorescent nucleoside phosphates

Publications (2)

Publication Number Publication Date
JP2024513957A true JP2024513957A (ja) 2024-03-27
JP2024513957A5 JP2024513957A5 (https=) 2025-04-18

Family

ID=75949388

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023562564A Pending JP2024513957A (ja) 2021-04-12 2022-04-11 蛍光ヌクレオシドホスフェート

Country Status (6)

Country Link
US (1) US20240209016A1 (https=)
EP (1) EP4323373A1 (https=)
JP (1) JP2024513957A (https=)
CA (1) CA3216383A1 (https=)
GB (1) GB2605952A (https=)
WO (1) WO2022218943A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116217753B (zh) * 2023-01-04 2024-02-23 齐鲁工业大学(山东省科学院) 木聚糖粘度荧光探针的制备方法及其应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014114326A1 (en) * 2013-01-22 2014-07-31 Universität Hamburg Method for the solid-phase based synthesis of phosphate-bridged nucleoside conjugates

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5594121A (en) * 1991-11-07 1997-01-14 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified purines
EP0695306A1 (en) * 1993-04-19 1996-02-07 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified purines

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014114326A1 (en) * 2013-01-22 2014-07-31 Universität Hamburg Method for the solid-phase based synthesis of phosphate-bridged nucleoside conjugates

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHEMISTRY A EUROPEAN JOURNAL, vol. 21, no. 46, JPN6025046725, 2015, pages 16421 - 16426, ISSN: 0005733274 *
NUCLEIC ACIDS RESEARCH, vol. 48, no. 14, JPN6025046727, 2020, pages 7640 - 7652, ISSN: 0005733272 *
PHYSICAL CHEMISTRY CHEMICAL PHYSICS, vol. 20, no. 45, JPN6025046726, 2018, pages 28487 - 28498, ISSN: 0005733273 *

Also Published As

Publication number Publication date
GB2605952A (en) 2022-10-26
EP4323373A1 (en) 2024-02-21
US20240209016A1 (en) 2024-06-27
CA3216383A1 (en) 2022-10-20
WO2022218943A1 (en) 2022-10-20
GB202105194D0 (en) 2021-05-26

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