JP2024512024A5 - - Google Patents
Info
- Publication number
- JP2024512024A5 JP2024512024A5 JP2023558377A JP2023558377A JP2024512024A5 JP 2024512024 A5 JP2024512024 A5 JP 2024512024A5 JP 2023558377 A JP2023558377 A JP 2023558377A JP 2023558377 A JP2023558377 A JP 2023558377A JP 2024512024 A5 JP2024512024 A5 JP 2024512024A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- pharmaceutically acceptable
- stereoisomer
- prodrug
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202163164804P | 2021-03-23 | 2021-03-23 | |
| US63/164,804 | 2021-03-23 | ||
| PCT/US2022/021573 WO2022204299A1 (en) | 2021-03-23 | 2022-03-23 | Pyrimidine derivatives useful as lrrk2 kinase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2024512024A JP2024512024A (ja) | 2024-03-18 |
| JP2024512024A5 true JP2024512024A5 (https=) | 2025-03-18 |
Family
ID=81328290
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023558377A Pending JP2024512024A (ja) | 2021-03-23 | 2022-03-23 | Ｌｒｒｋ２キナーゼ阻害剤として有用なピリミジン誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| US (4) | US11578061B2 (https=) |
| EP (1) | EP4313955A1 (https=) |
| JP (1) | JP2024512024A (https=) |
| KR (1) | KR20230170684A (https=) |
| CN (1) | CN117355507A (https=) |
| AU (1) | AU2022246081A1 (https=) |
| BR (1) | BR112023019388A2 (https=) |
| CA (1) | CA3214360A1 (https=) |
| CO (1) | CO2023012903A2 (https=) |
| IL (1) | IL306008A (https=) |
| MX (1) | MX2023011027A (https=) |
| WO (1) | WO2022204299A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2024512024A (ja) | 2021-03-23 | 2024-03-18 | ハリア・セラピューティクス・インコーポレイテッド | Ｌｒｒｋ２キナーゼ阻害剤として有用なピリミジン誘導体 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0619343D0 (en) | 2006-09-30 | 2006-11-08 | Vernalis R&D Ltd | New chemical compounds |
| TW201024281A (en) | 2008-11-24 | 2010-07-01 | Boehringer Ingelheim Int | New compounds |
| KR101445012B1 (ko) | 2009-12-17 | 2014-09-26 | 머크 샤프 앤드 돔 코포레이션 | Ｓｙｋ 억제제로서의 아미노피리미딘 |
| EP2512246B1 (en) | 2009-12-17 | 2015-09-30 | Merck Sharp & Dohme Corp. | Aminopyrimidines as syk inhibitors |
| ES2577829T3 (es) | 2010-06-04 | 2016-07-19 | F. Hoffmann-La Roche Ag | Derivados de aminopirimidina como moduladores de la LRRK2 |
| NO2638031T3 (https=) * | 2010-11-10 | 2018-03-10 | ||
| AR089182A1 (es) * | 2011-11-29 | 2014-08-06 | Hoffmann La Roche | Derivados de aminopirimidina como moduladores de lrrk2 |
| NO3004079T3 (https=) | 2013-06-04 | 2018-06-16 | ||
| RU2016134751A (ru) | 2014-01-29 | 2018-03-02 | Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед | Соединения |
| EP3144292B1 (en) | 2014-04-14 | 2020-08-26 | Shanghai Haiyan Pharmaceutical Technology Co., Ltd | 2,3,4,6-tetra-substituted benzene-1,5-diamine derivatives, preparation method therefor and medicinal use thereof |
| US11214565B2 (en) | 2015-11-20 | 2022-01-04 | Denali Therapeutics Inc. | Compound, compositions, and methods |
| US11028080B2 (en) | 2016-03-11 | 2021-06-08 | Denali Therapeutics Inc. | Substituted pyrimidines as LRKK2 inhibitors |
| US11174248B2 (en) | 2017-10-11 | 2021-11-16 | Merck Sharp & Dohme Corp. | Indazolyl-spiro[2.3]hexane-carbonitrile derivatives as LRRK2 inhibitors, pharmaceutical compositions, and uses thereof |
| JP7208240B2 (ja) | 2017-12-19 | 2023-01-18 | ブリストル－マイヤーズ スクイブ カンパニー | Ｌｐａアンタゴニストとしてのシクロヘキシル酸トリアゾールアジン |
| CN110872277B (zh) | 2019-11-14 | 2021-06-04 | 浙江大学 | N-取代芳环-2-氨基嘧啶类化合物及用途 |
| JP2024512024A (ja) * | 2021-03-23 | 2024-03-18 | ハリア・セラピューティクス・インコーポレイテッド | Ｌｒｒｋ２キナーゼ阻害剤として有用なピリミジン誘導体 |
-
2022
- 2022-03-23 JP JP2023558377A patent/JP2024512024A/ja active Pending
- 2022-03-23 CN CN202280036432.0A patent/CN117355507A/zh active Pending
- 2022-03-23 CA CA3214360A patent/CA3214360A1/en active Pending
- 2022-03-23 MX MX2023011027A patent/MX2023011027A/es unknown
- 2022-03-23 AU AU2022246081A patent/AU2022246081A1/en active Pending
- 2022-03-23 WO PCT/US2022/021573 patent/WO2022204299A1/en not_active Ceased
- 2022-03-23 EP EP22715927.4A patent/EP4313955A1/en active Pending
- 2022-03-23 BR BR112023019388A patent/BR112023019388A2/pt unknown
- 2022-03-23 IL IL306008A patent/IL306008A/en unknown
- 2022-03-23 US US17/702,600 patent/US11578061B2/en active Active
- 2022-03-23 KR KR1020237035536A patent/KR20230170684A/ko active Pending
- 2022-12-13 US US18/065,259 patent/US11866423B2/en active Active
-
2023
- 2023-09-28 CO CONC2023/0012903A patent/CO2023012903A2/es unknown
- 2023-11-20 US US18/514,959 patent/US12428404B2/en active Active
-
2025
- 2025-09-04 US US19/319,120 patent/US20260055087A1/en active Pending
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